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All Journal Journal of Food and Pharmaceutical Science JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Food and Pharmaceutical Sciences
Helmy Yusuf
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Other

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Influence of Hesperetin Concentration in Poloxamer P84 and TPGS Mixed Micelles on Physical Characteristics and Cytotoxicity in T47D Cell Line Nanda Intan Aulia; Muh. Agus Syamsur Rijal; Helmy Yusuf
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.104-113

Abstract

Background: Hesperetin is a natural compound that has several properties including anticancer, but has limitation on low solubility in water. In this case, the development of a hesperetin delivery system using the micellar system is carried out. Objective: The current study aims to determine the effect of drug concentration on the physical characteristics and cytotoxicity of the mixed micelle. Methods: In this study, mixed micelles were formulated with D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) and poloxamer P84 as polymers through the thin film method, with hesperetin loaded at four different concentrations, i.e., 5 mg (F1), 10 mg (F2), 20 mg (F3), and 40 mg (F4). The mixed micelles were formulated using thin film hydration method. The evaluation of micelle’s physical characteristics was the measurement of particle size, Critical Micelle Concentration (CMC) value, drug loading, and drug entrapment efficiency. The evaluation of cytotoxicity used the T47D cell line and Micro Tetrazolium (MTT) method. Results: The CMC value of the mixed micelle was 0.0029% w/v, which was lower than the CMC of TPGS and poloxamer P84 only. The particle size of the micelles produced was between 17.07–20.37 nm. Among the various formulations, F3 showed relatively small particle size and has homogeneous particle size, high drug loading and encapsulation efficiency, and low IC50. Based on the study, particle size of F3 was 17.93  0.32 nm with polydispersity index (PDI) of 0.256 0.034. The drug loading percentage of F3 was 4.0092  0.0048% with an encapsulation efficiency of 94.5492 0.0013%. Based on cytotoxicity test using MTT method, F3 has low IC50, there was 4.036 ppm. Conclusion: Hesperetin-loaded mixed micelles offer potential as anticancer drugs that improve hesperetin efficacy. The results showed that F3 was the most potent anticancer formulation based on the physical characteristics and cytotoxicity tests.
Formulation and Characterization of Curcumin Micellar Powder Sublingual Tablets Nina Wijiani; Helmy Yusuf; Dewi Isadiartuti; Mikhania Christiningtyas Eryani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28325

Abstract

Curcumin is the most active compound contained in turmeric rhizome (Curcuma longa). Curcumin has low solubility in water, which affects its bioavailability. Efforts to increase curcumin solubility are made in micelle systems. However, micelle solutions have the short shelf life, so they need to be to be converted to dry micelle powder by spray drying. Curcumin micelle powder was formulated into sublingual tablets to provide a convenient dosage form, which may improve patient compliance due to ease of administration and avoidance of swallowing difficulties. This study aims to manufacture sublingual tablets containing curcumin micelles prepared with varying concentrations of sucrose and casein and to characterize them. Tablets were prepared by direct compression method. Tablet characterization carried out included tablet hardness, tablet friability, tablet disintegration time, and dissolution. The results showed that all formulas met the requirements for hardness, friability, disintegration time, and dissolution. This study concludes that variations in casein and sucrose concentrations affect the friability, disintegration time, and dissolution of sublingual tablets but do not affect tablet hardness.
Formulation and Characterization of Curcumin Micellar Powder Sublingual Tablets Nina Wijiani; Helmy Yusuf; Dewi Isadiartuti; Mikhania Christiningtyas Eryani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28325

Abstract

Curcumin is the most active compound contained in turmeric rhizome (Curcuma longa). Curcumin has low solubility in water, which affects its bioavailability. Efforts to increase curcumin solubility are made in micelle systems. However, micelle solutions have the short shelf life, so they need to be to be converted to dry micelle powder by spray drying. Curcumin micelle powder was formulated into sublingual tablets to provide a convenient dosage form, which may improve patient compliance due to ease of administration and avoidance of swallowing difficulties. This study aims to manufacture sublingual tablets containing curcumin micelles prepared with varying concentrations of sucrose and casein and to characterize them. Tablets were prepared by direct compression method. Tablet characterization carried out included tablet hardness, tablet friability, tablet disintegration time, and dissolution. The results showed that all formulas met the requirements for hardness, friability, disintegration time, and dissolution. This study concludes that variations in casein and sucrose concentrations affect the friability, disintegration time, and dissolution of sublingual tablets but do not affect tablet hardness.
Co-Authors Dewi Isadiartuti Mikhania Christiningtyas Eryani Muh. Agus Syamsur Rijal Nanda Intan Aulia Nina Wijiani