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All Journal Buletin Ilmiah Nagari Membangun Journal of Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research JUBIDA-Jurnal Kebidanan
Rina Gustuti
Fetomaternal Division, Obstetrics And Gynecology Departement, Medical Faculty Of Universitas Andalas , Padang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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LAPORAN KASUS: EVALUASI MIKROSKOPIS VILI KORIONIK PADA MOLA PARSIAL Rina Gustuti; Rahma Afifah; Yusrawati
JUBIDA- Jurnal Kebidanan Vol. 4 No. 1 (2025)
Publisher : Yayasan Rahmatan Fidunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jubida.v4i1.1537

Abstract

Pendahuluan: Gestational Trophoblastic Disease (GTD) adalah kelainan trofoblastik plasenta dengan potensi invasif. Partial hydatidiform mole (PHM) merupakan bentuk premaligna yang sulit dibedakan secara klinis. Diagnosis memerlukan USG dan konfirmasi histopatologi. Deteksi dini penting untuk mencegah komplikasi dan memastikan penatalaksanaan yang tepat melalui evakuasi dan pemantauan β-HCG. Metode: Jurnal ini menggunakan desain laporan kasus yang menggambarkan seorang pasien berusia 22 tahun, G6P5A0H4, yang datang pada usia kehamilan 13–14 minggu dengan dugaan mola hidatidosa parsial. Tujua : Untuk memaparkan suatu kasus mola hidatidosa parsial serta mengevaluasi kesesuaian diagnosis antara hasil ultrasonografi dan histopatologi. Hasil: Perempuan 22 tahun, G6P5A0H4, datang pada usia kehamilan 13–14 minggu dengan dugaan mola hidatidosa parsial dan kematian janin dini. USG menunjukkan massa intrauterin hiperekoik seperti sarang lebah, dengan peningkatan β-HCG. Induksi mekanik berhasil mengeluarkan jaringan janin dan plasenta tanpa komplikasi. Plasenta berukuran 6 × 3 × 2 cm, padat, tanpa vesikel tampak. Mikroskopis menunjukkan vili fibrotik, perdarahan, sel fibroblas, desidua, kalsifikasi fokal, dan jaringan amnion. Namun, struktur vili yang padat dan fibrotik serta fitur terkait lainnya menyimpang dari gambaran klasik mola hidatidosa parsial. Rekomendasi : Deteksi dini untuk kasus mola hidatidosa diperlukan guna mencegah keganasan. Sangat penting untuk mengevaluasi hasil klinis dan temuan patologis dalam deteksi dini kasus ini
LAPORAN KASUS: DIAGNOSIS DAN PENATALAKSANAAN MOLA HIDATIDOSA KOMPLET DENGAN MANIFESTASI BADAI TIROID Rina Gustuti; Muhammad Brahmana Putra; Yusrawati
JUBIDA- Jurnal Kebidanan Vol. 4 No. 1 (2025)
Publisher : Yayasan Rahmatan Fidunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jubida.v4i1.1539

Abstract

Pendahuluan: Mola hidatidosa merupakan bentuk penyakit yang paling umum. Wanita pada tahap akhir reproduksi memiliki risiko lebih tinggi, terutama usia di atas 45 tahun. Komplikasi yang umum terjadi pada mola hidatidosa berupa perdarahan hebat sebelum deteksi dini dan teknik evakuasi uterus yang efektif. Mola invasif memiliki angka kematian sebesar 15% akibat perdarahan, embolisasi jaringan trofoblastik, dan sepsis. Komplikasi klasik mola hidatidosa selama kehamilan meliputi aborsi spontan, kematian intrauterin, hipertiroidisme, dan preeklamsia. Laporan kasus: Wanita 24 tahun, G2P1A0H1 dengan dugaan MHK memiliki riwayat perdarahan vagina, dengan USG menunjukkan gambaran honeycomb. Kuretase dilakukan pada pasien dan pemeriksaan histopatologi untuk mendukung diagnosis. Selain itu ditemukan kondisi badai tiroid tanpa adanya riwayat hipertiroidisme, sehingga diduga terjadi akibat mola hidatidosa komplet ini. Sehingga pada pasien diberikan penatalaksanaan badai tiroid. Kesimpulan: Pada pasien ini didapatkan diagnosis MHK dari anamnesis, penunjang seperti pemeriksaan USG, β-hCG, dan histopatologi. Penatalaksanaan dilakukan sesuai prinsip tatalaksana dengan kuretase untuk mengevakuasi mola dan mencegah perdarahan pasca operasi serta penatalaksanaan lain terkait komplikasi seperti anemia berat dan hipertiroidisme yang terjadi pada pasien ini. Diperlukan evaluasi lebih lanjut terkait kadar β-hCG yang dapat menentukan prognosis dan kekambuhan pada pasien, serta evaluasi dini terkait tiroid juga perlu dilakukan pada pasien dengan diagnosis mola hidatidosa.
LAPORAN KASUS : ANEMIA HEMOLITIK AUTOIMUN PADA KEHAMILAN DENGAN COOMBS TES NEGATIF Rina Gustuti; Nurul Fitriyah; Yusrawati
JUBIDA- Jurnal Kebidanan Vol. 4 No. 2 (2025)
Publisher : Yayasan Rahmatan Fidunya Wal Akhirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58794/jubida.v4i2.1945

Abstract

Pendahuluan: Anemia hemolitik autoimun yang terjadi pada masa kehamilan merupakan kondisi yang jarang dijumpai, namun berpotensi menimbulkan keadaan yang mengancam keselamatan ibu dan janin. Manifestasi klinis berupa anemia berat yang disertai ikterus, serta tidak adanya perbaikan kadar hemoglobin meskipun telah dilakukan transfusi darah, dapat menjadi petunjuk penting dalam menegakkan kecurigaan terhadap anemia hemolitik autoimun. Laporan Kasus: Wanita berusia 21 tahun dengan kehamilan pertama yang menunjukkan seluruh karakteristik klinis tersebut. Proses diagnostik menghadapi kendala karena pemeriksaan Coombs test memberikan hasil negatif, sehingga diagnosis tidak dapat ditegakkan secara langsung berdasarkan pemeriksaan penunjang standar. Penegakan diagnosis akhirnya didukung oleh respons klinis yang cepat dan signifikan setelah pemberian terapi kortikosteroid oral, yang memperkuat dugaan adanya mekanisme autoimun sebagai penyebab hemolisis. Setelah diagnosis ditegakkan dan terapi yang sesuai diberikan, terjadi perbaikan kondisi pasien dan peningkatan kadar hemoglobin, sehingga memungkin untuk dilakukan terminasi kehamilan. Kesimpulan: Keberhasilan tatalaksana maternal dan perinatal yang optimal dapat dicapai melalui pengenalan dini, kecurigaan klinis yang adekuat, serta penatalaksanaan yang cepat dan tepat pada kasus anemia hemolitik autoimun dalam kehamilan.
Edukasi Interaktif untuk Meningkatkan Pengetahuan Ibu Hamil tentang Komplikasi Kehamilan dan Pencegahan Stunting di Puskesmas Pauh Padang: Improving Pregnant Women’s Knowledge of Pregnancy Complications and Stunting Prevention through Interactive Education at Pauh Primary Health Center, Padang Yusrawati Yusrawati; Bobby Indra Utama; Vaulinne Basyir; Dovy Djanas; Rina Gustuti; Defrin; Nelvianti Nelson; Syamel Muhammad; Puja Agung Antonius; Sukri Rahman; Mela Aryati; Ardiles; Danil Armand; Zeino Fridsto; Subhan Arif Rahman; Aswin Boy Pratama; Dian Noviyanti; Edward Hariyadi; Irfan Kurnia; Rena Afri Ningsih; Rezi Liawati; Yesi Anggriani; Sakina Munira; Sara Uzlifah
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 9 No. 1 (2026)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v9i1.841

Abstract

Maternal mortality and stunting remain major public health challenges in Indonesia, largely due to limited early detection of pregnancy complications and low maternal health literacy during the First 1000 Days of Life. Strengthening maternal knowledge through structured education is essential to improve pregnancy outcomes. This community service program aimed to enhance pregnant women’s knowledge of pregnancy danger signs, completion of six antenatal care (ANC) visits, anemia prevention, balanced nutrition, and early stunting prevention. A community-based participatory approach using a service-learning model was implemented among 39 pregnant women at Pauh Primary Health Center, Padang. Educational activities were conducted through interactive lectures, group discussions, and question-and-answer sessions. Knowledge was assessed using pre-test and post-test instruments and analyzed with a paired t-test. The results showed a significant increase in mean knowledge scores from 77.98 ± 16.26 to 86.60 ± 11.18 (p = 0.0002). The proportion of participants with “good” knowledge increased from 66.6% to 76.6%, while those with “poor” knowledge decreased substantially. These findings indicate that interactive and structured maternal health education effectively improves understanding of pregnancy complications and stunting prevention. Continuous implementation through routine maternal classes and stronger family involvement is recommended to sustain behavioral changes and improve maternal and child health outcomes.
When Bleeding Stops but Organs Fail: Fatal Multiple Organ Dysfunction Syndrome Following Massive Atonic Postpartum Haemorrhage in a Young Primipara — A Case Report Rina Gustuti; Arianti Arifin; Yusrawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 9 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i9.1648

Abstract

Background: Postpartum haemorrhage from uterine atony can precipitate profound haemorrhagic shock within minutes, and in resource-constrained referral systems the interval between the onset of bleeding and definitive source control is frequently the decisive determinant of survival. Case presentation: We describe a 28-year-old primipara referred four hours after a vacuum-assisted vaginal delivery of twins complicated by severe pre-eclampsia. On arrival she was stuporous, hypotensive (70/68 mmHg), tachycardic (142 beats/min) and oliguric, with active vaginal bleeding and a haemoglobin of 2.4 g/dL. Resuscitation and haemorrhage control proceeded in parallel: high-flow oxygen, dual large-bore access, crystalloid and colloid loading, tranexamic acid, balanced blood-component transfusion, bimanual compression, intubation and emergency laparotomy. A flaccid, bluish, atonic uterus and a fourth-degree perineal tear were identified; subtotal hysterectomy with sphincteroplasty and perineorrhaphy achieved haemostasis. Despite massive transfusion and intensive care, prolonged hypoperfusion evolved into ischaemic hepatitis, severe coagulopathy, stage III acute kidney injury requiring haemodialysis, hospital-acquired pneumonia with drug-resistant sepsis, acute pulmonary oedema and upper gastrointestinal bleeding. Progressive multiple organ dysfunction syndrome culminated in asystolic cardiac arrest on postoperative day 15. Conclusion: This case illustrates a principle easily overlooked: definitive surgical haemostasis does not reverse organ injury already committed during the pre-operative shock interval. Objective cumulative blood-loss measurement, immediate haemorrhage-bundle and massive-transfusion protocol activation, explicitly documented uterotonic therapy, rapid balanced resuscitation and structured post-haemostasis organ surveillance are the interventions most likely to interrupt the lethal trajectory.
When Bleeding Stops but Organs Fail: Fatal Multiple Organ Dysfunction Syndrome Following Massive Atonic Postpartum Haemorrhage in a Young Primipara — A Case Report Rina Gustuti; Arianti Arifin; Yusrawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 9 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i9.1648

Abstract

Background: Postpartum haemorrhage from uterine atony can precipitate profound haemorrhagic shock within minutes, and in resource-constrained referral systems the interval between the onset of bleeding and definitive source control is frequently the decisive determinant of survival. Objective: To document, in granular day-by-day detail, the evolution of fatal multiple organ dysfunction syndrome following massive atonic postpartum haemorrhage in a young woman with no antecedent organ disease, and to translate that trajectory into transferable lessons for haemorrhage systems in resource-limited settings. Case presentation: We describe a 28-year-old primipara referred four hours after a vacuum-assisted vaginal delivery of twins complicated by severe pre-eclampsia. On arrival she was stuporous, hypotensive (70/68 mmHg), tachycardic (142 beats/min) and oliguric, with active vaginal bleeding and a haemoglobin of 2.4 g/dL. Resuscitation and haemorrhage control proceeded in parallel: high-flow oxygen, dual large-bore access, crystalloid and colloid loading, tranexamic acid, balanced blood-component transfusion, bimanual compression, intubation and emergency laparotomy. A flaccid, bluish, atonic uterus and a fourth-degree perineal tear were identified; subtotal hysterectomy with sphincteroplasty and perineorrhaphy achieved haemostasis. Despite massive transfusion and intensive care, prolonged hypoperfusion evolved into ischaemic hepatitis, severe coagulopathy, stage III acute kidney injury requiring haemodialysis, hospital-acquired pneumonia with drug-resistant sepsis, acute pulmonary oedema and upper gastrointestinal bleeding. Progressive multiple organ dysfunction syndrome culminated in asystolic cardiac arrest on postoperative day 15. Conclusion: This case illustrates a principle easily overlooked: definitive surgical haemostasis does not reverse organ injury already committed during the pre-operative shock interval. Objective cumulative blood-loss measurement, immediate haemorrhage-bundle and massive-transfusion protocol activation, explicitly documented uterotonic therapy, rapid balanced resuscitation and structured post-haemostasis organ surveillance are the interventions most likely to interrupt the lethal trajectory.
Prenatal Diagnosis of Omphalocele and Soft Markers of Chromosomal Abnormalities In The First Trimester Rina Gustuti
Journal of Midwifery Vol. 10 No. 2 (2025): Published on Desember 2025
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.10.2.66-71.2025

Abstract

Physiological herniation of the fetal midgut into the umbilical cord occurs during early embryonic development as a result of limited intra-abdominal space and is considered a normal finding until approximately 10-11 weeks of gestation. Persistence of midgut herniation beyond 12 weeks of gestation, or the presence of a herniated mass with a diameter exceeding 7 mm, is regarded as pathological and consistent with a diagnosis of omphalocele. Early identification during the first trimester is of substantial clinical importance, as omphalocele is frequently associated with chromosomal abnormalities, particularly trisomy 18, trisomy 13, and trisomy 21. In this setting, healthcare providers especially midwives working in close collaboration with fetomaternal specialists play a pivotal role in early screening, timely referral, and provision of psychosocial support. We report the case of a 22-year-old woman, gravida 2 para 1 abortus 0 living 1 (G2P1A0H1), at 11 weeks of gestation, who presented with hyperemesis gravidarum complicated by mild to moderate dehydration and reduced oral intake. Fetomaternal ultrasonography demonstrated a single live intrauterine fetus consistent with gestational age, with a crown– rump length of 39.4 mm (15.3rd percentile) and a regular fetal heart rate of 164 beats per minute. Notable findings included a markedly increased nuchal translucency of 6.8 mm, visualization of the nasal bone, normal ductus venosus Doppler flow, and a 9-mm membranous herniation at the umbilical cord insertion, consistent with omphalocele. In conclusion, first-trimester ultrasonography enabled early prenatal diagnosis of omphalocele accompanied by chromosomal soft markers. Further management includes cytogenetic analysis and a detailed second- trimester anatomical assessment, supported by comprehensive counseling to facilitate informed clinical decision-making.
Prenatal Diagnosis and Perinatal Management of Gastroschisis: A Case Report Rina Gustuti; Farah Mutiara; Yusrawati
Journal of Midwifery Vol. 10 No. 2 (2025): Published on Desember 2025
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.10.2.72-77.2025

Abstract

Background: Gastroschisis is a congenital abdominal wall defect characterized by herniation of abdominal organs through a paraumbilical defect without a protective membrane. Prenatal detection plays a crucial role in planning delivery and optimizing neonatal management. Case Presentation: We report a case of a 39-year-old pregnant woman, G4P2A1L2, who presented at 36–37 weeks of gestation with latent phase of labor and a history of two previous cesarean sections. Antenatal ultrasonography revealed a singleton live intrauterine fetus with suspected gastroschisis, demonstrated by herniation of fetal bowel outside the abdominal cavity without a covering membrane. Fetal well-being assessment using cardiotocography showed a category I tracing. Delivery was performed by cesarean section due to maternal obstetric indications. A male neonate was delivered with a birth weight of 2415 grams, and postnatal Ballard scoring indicated a gestational age of approximately 36 weeks. The neonate was planned for further management according to clinical condition. Conclusion: Prenatal diagnosis of gastroschisis allows for appropriate delivery planning and early neonatal management. A multidisciplinary approach involving obstetricians, neonatologists, and pediatric surgeons is essential to improve outcomes in neonates with congenital  abdominal wall defects.
Co-Authors Ardiles Arianti Arifin Aswin Boy Pratama Bobby Indra Utama Danil Armand Defrin Dian Noviyanti Dovy Djanas Edward Hariyadi Farah Mutiara Irfan Kurnia Mela Aryati Muhammad Brahmana Putra Nelvianti Nelson Nurul Fitriyah Puja Agung Antonius Rahma Afifah Rena Afri Ningsih Rezi Liawati Sakina Munira Sara Uzlifah Subhan Arif Rahman Sukri Rahman Syamel Muhammad Vaulinne Basyir Yesi Anggriani Yusrawati Yusrawati Zeino Fridsto