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All Journal Jurnal Biologi Tropis Jurnal Ilmiah Ilmu Kesehatan
Danda Ananda
Universitas Mataram
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Menimbang Harapan dan Kenyataan dalam Penggunaan Proton Pump Inhibitor sebagai Tata Laksana Gastritis: Suatu Kajian Literatur dan Perspektif Klinik Danda Ananda; Dewa Ngakan Nyoman Karyana; Baiq Afra Nurfadilah; Farhan Aqil Putra Hermawan; Muthiah Rahmahdani; Ni Luh Putu Eka Widya Ananta Putri; Nurhidayati
PrimA: Jurnal Ilmiah Ilmu Kesehatan Vol. 12 No. 1 (2026): PrimA: Jurnal Ilmiah Ilmu Kesehatan
Publisher : LPPM STIKES Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47506/8x7swp85

Abstract

Abstract Introduction: Gastritis is common gastrointestinal disorder characterized by inflammation of the gastric mucosa caused by various factors, including excessive gastric acid secretion. Proton Pump Inhibitors (PPIs) are widely used in the management of gastritis due to their effective mechanism in suppressing gastric acid production. Objective: To comprehensively review the role of PPIs in the management of gastritis, including their history, definition, mechanism of action, classification, effectiveness as monotherapy or in combination, as well as potential adverse effects and their prevention. Method: This study employed a literature review method with a descriptive qualitative approach. Articles were retrieved from PubMed, ScienceDirect, and Google Scholar using the keywords "proton pump inhibitor," "PPI," "gastritis", "acid suppression therapy," and "mucosal healing." Inclusion criteria were full-text articles in Indonesian or English that published within the last 5-10 years. Results: PPIs have been shown to effectively and irreversibly suppress gastric acid secretion by inhibiting the H+/K+-ATPase pump. As monotherapy, PPIs enhance mucosal healing and alleviate symptoms. In combination with other agents such as prokinetics, alginates, or H2RAs, PPIs provide better symptom control, particularly in refractory cases. However, long-term use may be associated with adverse effects. Conclusion: PPIs are an effective therapeutic option in the management of gastritis, both as monotherapy and in combination therapy. However, monitoring and prudent use are still necessary to reduce the risk of long-term side effects.
Vestibular Dysfunction in Adolescent Idiopathic Scoliosis: A Systematic Review of Diagnostic Challenges and Clinical Perspectives Seikha Cheany Fitriansyah; Azizah Tasyarani Khairunnisa; Danda Ananda; Lalu Muhammad Nuriel Akbar; Mufidah Radwah Ja'faruddin; Ni Luh Putu Faniacetta Dahayu Wedantari; Ilsa Hunaifi
Jurnal Biologi Tropis Vol. 26 No. 4 (2026): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i4.12358

Abstract

Adolescent Idiopathic Scoliosis (AIS) has traditionally been managed purely as a biomechanical structural deformity of the spine. However, recent evidence highlights the involvement of the central nervous system, particularly vestibular and sensorimotor dysfunction, in its pathogenesis. This systematic review aims to synthesize current literature on vestibular impairments and their impact on postural control in adolescents with AIS. A systematic literature search was conducted across electronic databases, including PubMed, ScienceDirect, and SpringerLink, to identify relevant studies. The inclusion criteria focused on articles evaluating vestibular function, sensorimotor integration, and postural control in patients with AIS, compared to either healthy controls or internal clinical parameters. The methodological quality and risk of bias of the included studies were appraised using the Joanna Briggs Institute (JBI) critical appraisal tools. Out of 137 initially screened records, 8 studies met the final inclusion criteria. Data synthesis reveals that AIS patients can actually maintain normal balance during simple static tasks due to a high-level of sensory compensation. However, their stability limits drop drastically when visual and proprioceptive inputs are manipulated. This instability strongly correlates with the severity of the Cobb angle. Structurally, imaging and neuro-otological evidence confirm the presence of anatomical asymmetries, such as abnormal lateral semicircular canal orientation and white matter disruptions in the corpus callosum. Furthermore, trials of neuromodulation interventions (combining peripheral and cortical stimulation) have proven effective in instantly reducing postural sway. AIS is a complex neurosensory syndrome driven by vestibular anatomical asymmetry and impaired central sensory integration, rather than purely a mechanical bone issue. Therefore, standard orthopedic management, such as bracing, should be complemented with routine neuro-otological screening and sensorimotor rehabilitation programs to address the root cause of postural instability.
Co-Authors Azizah Tasyarani Khairunnisa Baiq Afra Nurfadilah Dewa Ngakan Nyoman Karyana Farhan Aqil Putra Hermawan Ilsa Hunaifi Lalu Muhammad Nuriel Akbar Mufidah Radwah Ja'faruddin Muthiah Rahmahdani Ni Luh Putu Eka Widya Ananta Putri Ni Luh Putu Faniacetta Dahayu Wedantari Nurhidayati Seikha Cheany Fitriansyah