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All Journal Exacta: Journal of Pure and Fundamental Research Didakta: International Journal of Social Sciences, Language, and Education
Anjela Karunia Amalia
IPB University

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Microbial Resistance Evolution: Theoretical Perspectives on Genetic Mutation and Environmental Pressure Deford Cristy Birahy; Mia Audina; Anjela Karunia Amalia
Exacta: Journal of Pure and Fundamental Research Vol. 1 No. 1 (2026): March: Exacta: Journal of Pure and Fundamental Research
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/smcw0074

Abstract

Microbial resistance has traditionally been interpreted through reductionist frameworks emphasizing isolated genetic mutations or clinical antibiotic exposure. This study advances a non-empirical theoretical investigation grounded in integrative conceptual modeling to reconceptualize resistance evolution as a cross-scale, eco-evolutionary phenomenon. A multi-scale analytical framework was constructed to synthesize stochastic mutation supply, horizontal gene transfer, metabolic rewiring, proteostasis regulation, environmental heterogeneity, and anthropogenic chemical pressures into a unified systems architecture. Structured theoretical synthesis and boundary-condition analysis were employed to test internal coherence and cross-context stability. The model demonstrates that resistance emerges as a metastable adaptive state maintained by feedback loops linking molecular mechanisms, community-level interactions, and physicochemical gradients across environmental compartments. Disinfectant exposure, nutrient enrichment, wastewater co-selection, and climate variability were incorporated as dynamic modulators of selective intensity. The resulting framework exhibits explanatory integration, cross-scale generalizability, and predictive plausibility under fluctuating selective regimes. By situating microbial resistance within interconnected ecological and evolutionary systems, this study provides a robust theoretical platform capable of guiding future simulation-based modeling and empirical corroboration within the One Health continuum.
Civic Engagement and Critical Thinking Skills among Pre-Service Teachers in Multicultural Societies Muhammad Nurfaizi Arya Rahardja; Shavira Salsabila; Achmaf Afif Fikri; Moh. Imron Rosidi; Abid Nurhuda; Anjela Karunia Amalia
International Journal of Social Sciences, Language, and Education Vol. 1 No. 1 (2026): January: Didakta: International Journal of Social Sciences, Language, and Educa
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/pyd84749

Abstract

In multicultural societies, pre-service teachers are increasingly expected to function as educators who are both civically engaged and critically reflective. This study examines the conceptual relationship between civic engagement and critical thinking within pre-service teacher education through a qualitative library-based research approach. Drawing on peer-reviewed literature in teacher education, multicultural pedagogy, and democratic citizenship, the study analyzes how civic engagement experiences contribute to the development of higher-order thinking and ethical awareness among future teachers. The findings indicate that civic engagement, when framed through critical and multicultural pedagogical perspectives, fosters reflective judgment, democratic values, and intercultural sensitivity. Critical thinking emerges as a mediating capacity that enables pre-service teachers to interpret civic experiences analytically and respond constructively to social complexity. The study further highlights the role of critical reflection in transforming community engagement into professional knowledge. Overall, the analysis suggests that integrating civic engagement and critical thinking within teacher education strengthens the preparation of educators capable of promoting inclusive, democratic, and socially responsive learning environments in culturally diverse contexts.
Co-Authors Abid Nurhuda Achmaf Afif Fikri Deford Cristy Birahy Mia Audina Moh. Imron Rosidi Muhammad Nurfaizi Arya Rahardja Shavira Salsabila