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Microbial Resistance Evolution: Theoretical Perspectives on Genetic Mutation and Environmental Pressure Deford Cristy Birahy; Mia Audina; Anjela Karunia Amalia
Exacta: Journal of Pure and Fundamental Research Vol. 1 No. 1 (2026): March: Exacta: Journal of Pure and Fundamental Research
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/smcw0074

Abstract

Microbial resistance has traditionally been interpreted through reductionist frameworks emphasizing isolated genetic mutations or clinical antibiotic exposure. This study advances a non-empirical theoretical investigation grounded in integrative conceptual modeling to reconceptualize resistance evolution as a cross-scale, eco-evolutionary phenomenon. A multi-scale analytical framework was constructed to synthesize stochastic mutation supply, horizontal gene transfer, metabolic rewiring, proteostasis regulation, environmental heterogeneity, and anthropogenic chemical pressures into a unified systems architecture. Structured theoretical synthesis and boundary-condition analysis were employed to test internal coherence and cross-context stability. The model demonstrates that resistance emerges as a metastable adaptive state maintained by feedback loops linking molecular mechanisms, community-level interactions, and physicochemical gradients across environmental compartments. Disinfectant exposure, nutrient enrichment, wastewater co-selection, and climate variability were incorporated as dynamic modulators of selective intensity. The resulting framework exhibits explanatory integration, cross-scale generalizability, and predictive plausibility under fluctuating selective regimes. By situating microbial resistance within interconnected ecological and evolutionary systems, this study provides a robust theoretical platform capable of guiding future simulation-based modeling and empirical corroboration within the One Health continuum.
Sosialisasi Optimalisasi Pangan Lokal untuk Pangan Fungsional di SMP Negeri 5 Ambon Meillisa Carlen Mainassy; Cecilia Ana Seumahu; Deford Cristy Birahy; Indah Baharudin; Christo Putra Yehuda Likumahwa
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 6, No 2 (2026): Abdira, April
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v6i2.1792

Abstract

Local food has great potential as a source of functional food that plays a role in improving health quality and supporting regional food security. However, students' understanding of healthy food and the use of local food is still limited. This community service activity aims to increase the knowledge and awareness of students at SMP Negeri 5 Ambon regarding the optimization of local food as functional food, as well as encourage the formation of positive attitudes towards local food consumption. The methods used included educational and participatory socialization, and evaluation. The results of the activity showed that before the socialization, only about 30% of students were able to explain the concept of healthy food in general and less than 25% knew the function of local food as functional food. After the activity, students' understanding increased, as indicated by approximately 80% of students being able to explain the concept of functional food simply and 75% being able to identify examples of local food that have health benefits. In addition, approximately 70% of students were actively involved in discussions related to daily food consumption habits. This activity is expected to raise students' awareness to utilize local food as a healthy and nutritious alternative.