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All Journal Indonesian Journal of Innovation Multidisipliner Research The ASEAN Journal of Military and Preventive Medicine
Tessalonika Shinta Ratriani
Republic of Indonesia Defense University
Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Industrial & Manufacturing Engineering

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Angsana sap vs. povidone-iodine for wound healing in tropical and military settings Tessalonika Shinta Ratriani; Astheria Eryani; Surachman AJ Didy; Dian Andriani Ratna Dewi
The ASEAN Journal of Military and Preventive Medicine Vol. 3 No. 2 (2026): July
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v3i2.62

Abstract

Background: Wound infection remains a significant cause of morbidity in trauma patients, especially in battlefield and tropical settings where access to standard antiseptics is limited. Povidone-iodine 10% is commonly used due to its broad-spectrum antimicrobial activity; however, concerns about cytotoxicity and logistical constraints necessitate alternative antiseptic options. Methods: A narrative review was conducted using literature from PubMed, Scopus, and Google Scholar databases. Relevant studies were identified using combinations of MeSH terms and free-text keywords related to Pterocarpus indicus, natural antiseptics, povidone-iodine, wound infection, and trauma care. Findings were synthesized through thematic analysis. Discussion: Angsana (Pterocarpus indicus) sap contains bioactive compounds such as flavonoids, tannins, and terpenoids with antimicrobial and anti-inflammatory properties. These compounds may contribute to bacterial inhibition and enhanced tissue healing. Compared with povidone-iodine, which offers a broader antimicrobial spectrum, angsana sap may provide supportive effects on wound repair with potentially lower cytotoxicity. Evidence suggests it could serve as an alternative or adjunct in resource-limited environments, particularly in tropical and military contexts. Conclusion: Angsana sap demonstrates promising potential as a natural antiseptic for wound management. However, it cannot yet replace povidone-iodine due to limited clinical evidence. Further well-designed studies are needed to confirm its safety, efficacy, and applicability in clinical practice. Keywords: Pterocarpus indicus, angsana sap, povidone-iodine, wound infection, wound healing.
Comparative Evidence on the Topical Wound-Healing Potential of Sap, Stem Bark, and Leaves of Pterocarpus indicus: A Narrative Review Tessalonika Shinta Ratriani; Astheria Eryani; Ghani Phalosa
Indonesian Journal of Innovation Multidisipliner Research Vol. 4 No. 3 (2026): Juli - September
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69693/ijim.v4i3.1909

Abstract

Skin wounds require coordinated control of inflammation, oxidative stress, microbial contamination, and tissue regeneration. Pterocarpus indicus has traditionally been used for inflammatory, infectious, and skin-related conditions, but the relative suitability of its sap, stem bark, and leaves for topical wound-healing development remains unclear. This narrative review comparatively evaluated the phytochemical characteristics, pharmacological activities, direct wound-healing evidence, processing considerations, safety, and sustainability of these three plant parts. Relevant literature was identified through Scopus, PubMed, Web of Science, ScienceDirect, and Google Scholar, with priority given to phytochemical, in vitro, and in vivo studies. The reviewed evidence indicates that sap, stem bark, and leaves are pharmacologically distinct and should not be considered interchangeable materials. Stem bark currently provides the most direct wound-specific evidence through preclinical evaluation of re-epithelialization, although the findings remain preliminary and do not demonstrate superiority over the reference treatment. Leaves are supported mainly by antioxidant and antibacterial activities associated with flavonoids, terpenoids, and other secondary metabolites, whereas direct evidence for wound contraction and histopathological recovery remains insufficient. Sap contains flavonoids and has plausible astringent and antibacterial potential, but its chemical standardization, effective topical dose, dermal safety, formulation stability, and direct effects on tissue regeneration have not been adequately established. Consequently, none of the three plant parts can currently be considered definitively superior. Standardized head-to-head studies using equivalent doses, identical topical vehicles, relevant wound models, and integrated macroscopic, histopathological, microbiological, and safety outcomes are required to determine their comparative therapeutic value and translational feasibility.
Analisis Implementasi Kebijakan One Health dalam Penanggulangan Resistensi Antimikroba: Tantangan dan Strategi Multisektoral Tessalonika Shinta Ratriani; Soroy Lardo; Andreas Tuani Siahaan; Eddytia Syauqy Ilmani; Febriani Pali Palada; Feby Ingnesia Tamara Purba; Hafizh Elyanda Kurnia; Hafliza Amira; Immanuel Mattew Sitorus; Muhammad Raihan Abhenda Putra; Quinn Kay Setiawan; Alif Nurfattah Hakim
Indonesian Journal of Innovation Multidisipliner Research Vol. 4 No. 3 (2026): Juli - September
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69693/ijim.v4i3.1924

Abstract

Resistensi antimikroba (AMR) merupakan ancaman kesehatan global yang semakin meningkat akibat penggunaan antimikroba yang tidak rasional pada sektor kesehatan manusia, hewan, dan lingkungan. Pendekatan One Health dikembangkan sebagai strategi kolaboratif yang mengintegrasikan berbagai sektor dalam upaya pengendalian AMR secara berkelanjutan. Artikel ini bertujuan menganalisis implementasi kebijakan One Health dalam penanggulangan resistensi antimikroba, mengidentifikasi tantangan implementasi, serta merumuskan strategi multisektoral yang efektif. Metode yang digunakan adalah literature review terhadap publikasi ilmiah dari Google Scholar, PubMed, ScienceDirect, dan Web of Science. Hasil kajian menunjukkan bahwa pendekatan One Health telah diadopsi melalui berbagai kebijakan global dan nasional, termasuk Global Action Plan on Antimicrobial Resistance. Beberapa negara seperti Swedia dan Denmark berhasil menerapkan sistem surveilans terintegrasi yang mendukung penggunaan antibiotik secara rasional. Namun demikian, implementasi masih menghadapi sejumlah hambatan berupa lemahnya koordinasi lintas sektor, keterbatasan surveilans terpadu, rendahnya kepatuhan terhadap prinsip antimicrobial stewardship, serta pencemaran lingkungan akibat residu antimikroba. Strategi yang direkomendasikan meliputi penguatan program antimicrobial stewardship, integrasi sistem surveilans, peningkatan biosekuriti, pengelolaan limbah yang lebih baik, serta penguatan kolaborasi antarsektor. Keberhasilan implementasi One Health sangat bergantung pada komitmen pemerintah, kerjasama multisektoral, dan keselarasan kebijakan di tingkat nasional maupun global.
Co-Authors Alif Nurfattah Hakim Andreas Tuani Siahaan Astheria Eryani Astheria Eryani Dewi, Dian Andriani Ratna Eddytia Syauqy Ilmani Febriani Pali Palada Feby Ingnesia Tamara Purba Ghani Phalosa Hafizh Elyanda Kurnia Hafliza Amira Immanuel Mattew Sitorus Muhammad Raihan Abhenda Putra Quinn Kay Setiawan Soroy Lardo Surachman AJ Didy