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All Journal Environmental Pollution Journal
L. Suwandito
Universitas Katolik Widya Mandala Surabaya
Humanities Chemistry Engineering Environmental Science Law, Crime, Criminology & Criminal Justice

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Topical Polyethylene Exposure Induces Conjunctival Inflammation and Early Meibomian Gland Alterations in Wistar Rats Felicia Yoshe; Yudhiakuari Sincihu; Imelda Theodora; Titiek Ernawati; L. Suwandito
Environmental Pollution Journal Vol. 6 No. 1: April 2026
Publisher : ECOTON: Ecological Observation and Wetlands Conservation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58954/epj.v6i1.420

Abstract

Nanoplastics are plastic particles smaller than 1000 nm formed from plastic degradation, including polyethylene (PE) These particles can enter the eye through environmental exposure or topical products and may induce oxidative stress, inflammation, and Meibomian gland dysfunctionEvidence regarding ocular toxicity from topical nanoplastic exposure remains limited. To evaluate the effects of topical polyethylene nanoplastic exposure on ocular surface inflammation and Meibomian gland histology. This experimental post-test only study used male Rattus norvegicus Wistar rats receiving topical polyethylene nanoplastic eye drops. Histopathological analysis with Hematoxylin–Eosin staining assessed PMN infiltration, normal Meibomian acini, acinar width, and gland obstruction. PMN infiltration in the palpebral conjunctiva increased significantly (p=0.014), while normal Meibomian acini decreased significantly (p=0.000). Other parameters showed no significant differences. Topical polyethylene nanoplastic exposure induces conjunctival inflammation and early Meibomian gland alterations.
Effects of Oral Polyethylene Microplastic Dose on Wistar Rats’ Cognition Assessed by Morris Water Maze Michael Yohanes Kuncoro; Nita Kurniawati; Yudhiakuari Sincihu; Pauline Meryana; L. Suwandito
Environmental Pollution Journal Vol. 6 No. 1: April 2026
Publisher : ECOTON: Ecological Observation and Wetlands Conservation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58954/epj.v6i1.434

Abstract

Orally ingested polyethylene (LDPE) microplastics are suspected to impair cognitive function through disturbances in the central nervous system, particularly in cognitive regions such as the cortex and hippocampus. This study aims to evaluate the effect of varying oral doses of LDPE microplastics on the cognitive function of Wistar Rattus norvegicus using the Morris Water Maze (MWM) test. This experimental study employed a post-test only control group design involving 21 male Wistar rats divided into four groups: a control group and three treatment groups receiving LDPE microplastics at low dose and high dose administered orally for 28 days (particle size ≤20 µm). Cognitive function was assessed using the latency time to locate the hidden platform in the MWM and analyzed statistically. The mean latency tended to increase with increasing dose. Using the control group as the baseline, there was a slight increase in the outcome in the low dose group, and a markedly higher increase observed in the high dose group. Statistical analysis showed a significant difference between the control group and the high dose group (p = 0.009). Oral administration of LDPE microplastics at  high dose for 28 days was associated with a significant impairment in cognitive function.
Co-Authors Felicia Yoshe Imelda Theodora Michael Yohanes Kuncoro Nita Kurniawati Pauline Meryana Sincihu, Yudhiakuari Titiek Ernawati