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All Journal Jurnal Buana Farma
Muhammad Yunus
PUI Phyto Degenerative & Lifestyle Medicine, Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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UJI EFEKTIVITAS ANTIDIABETIK DAUN KIPAHIT (Tithonia diversifolia) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS MODEL DIABETES TERINDUKSI STREPTOZOTOCIN Nurul Hasanah; Astriani Natalia Br Ginting; Muhammad Yunus
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1615

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Tithonia diversifolia (Kipahit) leaves are traditionally used for diabetes. This study aims to determine the antidiabetic effectiveness of Kipahit leaf ethanol extract on blood glucose levels in streptozotocin (STZ)-induced diabetic rats. The research was an experimental laboratory study using a post-test only control group design. Thirty male rats were divided into six groups: normal control, negative control (STZ), positive control (STZ + metformin), and three treatment groups receiving the extract at doses of 250, 350, and 450 mg/kg BW. The extract yield was 29.67%. Phytochemical screening showed positive results for flavonoids, alkaloids, saponins, tannins, and steroids. Blood glucose levels were measured on days 0, 3, 6, 9, 12, and 15. Data were analyzed using One-Way ANOVA and Duncan's post hoc test. The results showed that the extract significantly reduced blood glucose levels. The dose of 450 mg/kg BW was the most effective, with an effect comparable to metformin.
FORMULASI SEDIAAN MASKER GEL PEEL OFF EKSTRAK DAUN SIRIH CINA (PEPEROMIA PELLUCIDA) Nurul Mawaddah Nasution; Astriani Natalia Br Ginting; Muhammad Yunus
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1622

Abstract

Acne vulgaris is a common skin disorder often associated with increased sebum production and colonization of Cutibacterium acnes on the skin. Peperomia pellucida L. is a medicinal plant known to contain secondary metabolites such as flavonoids, alkaloids, saponins, and tannins, which have potential for use in the development of natural cosmetic formulations. This study aimed to formulate Peperomia pellucida leaf extract into a peel-off gel mask preparation and evaluate its physical characteristics. The extraction of the leaves was carried out using a maceration method with 96% ethanol as the solvent. The obtained extract was then formulated into four different concentrations (0%, 2%, 4%, and 6%) using a gel base consisting of polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), triethanolamine (TEA), glycerin, nipagin, nipasol, and distilled water. The evaluation of the formulations included organoleptic observation, homogeneity test, pH measurement, drying time, and spreadability test. The results showed that all formulations produced homogeneous preparations with pH values ranging from 5.75 to 6.20, drying time between 15–25 minutes, and spreadability ranging from 6.3 to 6.8 cm. Increasing extract concentration affected the organoleptic characteristics and drying time of the preparations. Based on the physical evaluation results, the formulation containing 4% extract demonstrated the most optimal physical characteristics compared with the other formulations.
Co-Authors Astriani Natalia Br Ginting Astriani Natalia Br Ginting Nurul Hasanah Nurul Mawaddah Nasution