Nadia Azhar Samasta
Institut Agama Islam Negeri Kediri

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Negative Impact of Gene Therapy on Melanoma Disease Nadhea Aurel Zalfanisa Inzagi; Nadia Azhar Samasta; Dewi Ghitsatul Ala; Ibrahim Bin Said
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 1 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i1.936

Abstract

The incidence of melanoma is rapidly increasing worldwide, posing a significant public health problem. Gene therapy for treating diseases has been discovered since 1989. Research developments to make gene therapy an effective treatment method are ongoing. Primary extracutaneous melanoma can be ocular, gastrointestinal, mucosal, leptomeningeal, genitourinary, and lymphatic. The relationship between ultraviolet (UV) exposure and the development of melanoma is highly acute and complex, and intermittent sun exposure significantly increases the risk of melanoma. It is the fifth most common type of cancer in men and the sixth in women. Mucosal melanoma is a rare disease that differs from melanoma arising elsewhere in the body. Although melanocytes are most abundant in the skin, they can also be found in smaller numbers in mucous membranes and the eyes. There are epidemiological, genetic, and physiological differences between melanomas arising from melanocytes in these various locations, and these differences have important implications for both disease prognosis and treatment.
Differences in the Life Cycle and Growth of Plasmodium Knowlesi, Inui, Vivax, Malariae, Falciparum, Ovale Lidiya Fatmaningsih; Nadia Azhar Samasta; Linda Octa
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 2 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i2.1020

Abstract

Plasmodium is a parasite that causes malaria in humans. Various Plasmodium species have differences in their life cycles and growth, which influence the clinical characteristics and management of malaria. This article explains the differences in the life and growth cycles of the six Plasmodium species most commonly found in humans, namely Plasmodium knowlesi, Plasmodium inui, Plasmodium vivax, Plasmodium malariae, Plasmodium falciparum, and Plasmodium ovale. Each species has differences in its life cycle, including pre-erythrocytic, erythrocytic, and extracellular duration. In addition, these differences also influence clinical symptoms, disease severity, and response to treatment. A thorough understanding of these differences is important for accurate diagnosis and effective treatment of malaria.