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All Journal Journal of Biomedical and Techno Nanomaterials
Ibrahim Bin Said
Institut Agama Islam Negeri Kediri
Biochemistry, Genetics & Molecular Biology

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Negative Impact of Gene Therapy on Melanoma Disease Nadhea Aurel Zalfanisa Inzagi; Nadia Azhar Samasta; Dewi Ghitsatul Ala; Ibrahim Bin Said
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 1 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i1.936

Abstract

The incidence of melanoma is rapidly increasing worldwide, posing a significant public health problem. Gene therapy for treating diseases has been discovered since 1989. Research developments to make gene therapy an effective treatment method are ongoing. Primary extracutaneous melanoma can be ocular, gastrointestinal, mucosal, leptomeningeal, genitourinary, and lymphatic. The relationship between ultraviolet (UV) exposure and the development of melanoma is highly acute and complex, and intermittent sun exposure significantly increases the risk of melanoma. It is the fifth most common type of cancer in men and the sixth in women. Mucosal melanoma is a rare disease that differs from melanoma arising elsewhere in the body. Although melanocytes are most abundant in the skin, they can also be found in smaller numbers in mucous membranes and the eyes. There are epidemiological, genetic, and physiological differences between melanomas arising from melanocytes in these various locations, and these differences have important implications for both disease prognosis and treatment.
Genetic Engineering of Mosquitoes Causes Malaria Nur Afni Maulina Maghfiro; Lidiya Fatmaningsih; Maulidatul Aulia; Ibrahim Bin Said
Journal of Biomedical and Techno Nanomaterials Vol. 1 No. 2 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v1i2.1025

Abstract

Malaria is still a health problem in the world and in Indonesia in particular. Malaria vector control is an important strategy in efforts to control and eliminate malaria because it is very effective in preventing infection and reducing disease transmission. The CRISPR/Casnuclease system is a potent new genome editing system and tool for species-specific diagnosis, drug resistance research for Plasmodium species, and gene driver for Anopheles population control, according to an assessment of earlier genome editimg techniques. This Anopheles mosquito CRISPR/Cas9 technique on plasmodium has been applied in research to detect malaria parasites by inhibiting their growth throughout the life cycle, allowing evaluation of the effectiveness of antimalarial drugs or vaccines at various stages of the parasite life cycle. In addition, CRISPR/Cas9 in Anopheles mosquitoes allows identification and double-strand breaks in target DNA, which can then be modified through genome changes. So, with the development of gene editing technology, the spread of Anopheles mosquitoes can be controlled and reduced.
Co-Authors Dewi Ghitsatul Ala Lidiya Fatmaningsih Maulidatul Aulia Nadhea Aurel Zalfanisa Inzagi Nadia Azhar Samasta Nur Afni Maulina Maghfiro