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All Journal Journal of Health and Medical Science Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Nahla Aulia Azis
Universitas Muhammadiyah Makassar
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Penentuan Nilai LC₅₀ dan Kategori Toksisitas Ekstrak Etanol Daun Trembesi (Samanea saman (Jacq.) Merr.) Menggunakan Metode BSLT haryanto; Anggun Aldiansa; Masnaeni Thamrin; Asrianti Asrianti; Muhammad Chairul Anam; Anindya Rizke Handayani; Nahla Aulia Azis; Andi Tenriani Awaliyah
Journal of Health and Medical Science Vol. 5 No. 3 (2026): Volume 5 Nomor 3 Juli 2026
Publisher : CV. Pusdikra Mitra Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/jhms.v5i3.3648

Abstract

Daun trembesi (Samanea saman (Jacq.) Merr.) diketahui mengandung berbagai senyawa metabolit sekunder yang berpotensi memiliki aktivitas biologis, namun informasi mengenai tingkat toksisitasnya masih terbatas. Penelitian ini bertujuan untuk menentukan nilai LC₅₀ serta kategori toksisitas ekstrak etanol 60% daun trembesi terhadap larva Artemia salina Leach menggunakan metode probit. Penelitian ini merupakan penelitian eksperimental laboratorium dengan metode Brine Shrimp Lethality Test (BSLT). Ekstrak etanol 60% daun trembesi dibuat menggunakan metode maserasi, kemudian diuji pada larva Artemia salina Leach dengan variasi konsentrasi 10, 100, 500, 1.000, 5.000, dan 10.000 ppm, serta satu kelompok kontrol. Pengamatan dilakukan setelah 24 jam dengan menghitung jumlah larva yang mati pada setiap perlakuan. Data mortalitas dianalisis menggunakan metode probit untuk menentukan nilai LC₅₀. Hasil penelitian menunjukkan bahwa persentase kematian larva meningkat seiring dengan peningkatan konsentrasi ekstrak, yaitu sebesar 3,22%; 16,00%; 36,36%; 63,63%; 84,00%; dan 96,78%. Analisis probit menghasilkan nilai LC₅₀ sebesar ±544 ppm, yang berdasarkan klasifikasi Hayranto et al. (2023) termasuk dalam kategori moderat (Moderately Toxic) karena berada pada rentang 100–1.000 mg/L. Dengan demikian, ekstrak etanol 60% daun trembesi memiliki aktivitas toksisitas terhadap larva Artemia salina Leach dan berpotensi untuk dikembangkan sebagai sumber senyawa bioaktif, namun masih memerlukan penelitian lanjutan untuk mengidentifikasi senyawa aktif serta mengevaluasi keamanan dan aktivitas biologisnya secara lebih mendalam.
Evaluasi Aktivitas Farmakologi Simplisia Kopi Arabika (Coffea arabica) pada Berbagai Konsentrasi terhadap Sistem Saraf Otonom dan Sistem Saraf Pusat Anggun Aldiansa; Ilmi Nurashiilah; Nahla Aulia Azis; Nasifa Kayla Putri; Andi Tenriani Awaliyah; Ayu Azkiya; Aulya Nurul Imama R; Hilda Kadir; Muhammad Chairul Anam; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2015

Abstract

Arabica coffee (Coffea arabica) contains various bioactive compounds such as caffeine, polyphenols, flavonoids, and alkaloids that have the potential to produce diverse pharmacological effects on both the autonomic and central nervous systems. The variation in its chemical composition is influenced by factors such as cultivar, post-harvest processing, and preparation methods, resulting in biological responses that are dose-dependent and not always linear. This study aimed to evaluate the pharmacological activity of arabica coffee simplicia powder at three concentrations (1%, 2%, and 4%) by observing parasympathomimetic, parasympatholytic, sympathomimetic, sympatholytic, analeptic, central nervous system stimulation and depression, as well as muscle relaxation parameters. The research was conducted using a laboratory experimental design with test animals administered orally according to the designated concentrations. The results showed that some parameters increased at higher concentrations, such as parasympathomimetic activity (51.85%) and central nervous system stimulation (63.74%), while other parameters demonstrated decreasing or biphasic patterns, such as sympatholytic activity, which was high at 1% and 4% but low at 2%, and analeptic activity, which dropped sharply at 2% and increased again at 4%. These response patterns align with literature indicating that caffeine and polyphenols such as chlorogenic acid may interact synergistically or antagonistically, generating complex pharmacological effects through mechanisms involving adenosine modulation, excitatory neurotransmitters, the enteric nervous system, as well as antioxidant and anti-inflammatory pathways. Overall, this study demonstrates that arabica coffee simplicia exhibits multipotential pharmacological activity, with responses strongly influenced by concentration and the composition of its bioactive compounds, thereby providing a basis for further research on the phytopharmaceutical potential of arabica coffee.
Co-Authors Andi Tenriani Awaliyah Andi Utari Prasetya Ningrum Anggun Aldiansa Anindya Rizke Handayani Asrianti Asrianti Aulya Nurul Imama R Ayu Azkiya Haryanto Hilda Kadir Ilmi Nurashiilah Masnaeni Thamrin Muhammad Chairul Anam Nasifa kayla putri