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All Journal Journal of Health and Medical Science Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Nasifa kayla putri
Universitas Muhammadiyah Makassar
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Karakterisasi Tingkat Toksisitas Ekstrak Etanol Daun Trembesi (Samanea saman (Jacq.) Merr.) melalui Analisis Hubungan Konsentrasi–Mortalitas dan Estimasi Nilai LC₅₀ dengan Metode Probit Haryanto Haryanto; Nurul Izzatul Jannah; Azzahra Ramadani; Nur Azizah Khairani; Nur Sahra; Dhiva Rabiatul Maulia; Nasifa kayla putri; Muh. Yusuf Al-Habib Rachman
Journal of Health and Medical Science Vol. 5 No. 3 (2026): Volume 5 Nomor 3 Juli 2026
Publisher : CV. Pusdikra Mitra Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/jhms.v5i3.3655

Abstract

Daun trembesi (Samanea saman (Jacq.) Merr.) diketahui mengandung berbagai metabolit sekunder, seperti flavonoid, tanin, saponin, alkaloid, dan terpenoid yang berpotensi memberikan aktivitas biologis, namun informasi mengenai tingkat toksisitasnya masih terbatas. Penelitian ini bertujuan untuk mengkarakterisasi tingkat toksisitas ekstrak etanol 70% daun trembesi melalui analisis hubungan konsentrasi–mortalitas dan estimasi nilai LC₅₀ menggunakan metode probit. Penelitian ini merupakan penelitian eksperimental laboratorium dengan larva Artemia salina Leach sebagai organisme uji. Ekstrak diperoleh melalui metode maserasi menggunakan etanol 70%, kemudian dibuat dalam beberapa variasi konsentrasi, yaitu 10, 100, 500, 1.000, 5.000, dan 10.000 ppm. Masing-masing konsentrasi diuji terhadap 10 ekor larva Artemia salina dengan waktu pengamatan selama 24 jam. Data persentase kematian dianalisis menggunakan analisis probit untuk menentukan hubungan antara log konsentrasi dan respons mortalitas serta mengestimasi nilai LC₅₀. Hasil penelitian menunjukkan bahwa peningkatan konsentrasi ekstrak menyebabkan peningkatan persentase kematian larva, yaitu dari 6,89% pada konsentrasi 10 ppm menjadi 97,05% pada konsentrasi 10.000 ppm. Analisis probit menghasilkan nilai LC₅₀ sebesar 100,46 mg/L (ppm), yang berdasarkan klasifikasi toksisitas termasuk dalam kategori moderat (moderately toxic). Temuan ini menunjukkan bahwa ekstrak etanol 70% daun trembesi memiliki aktivitas toksik yang nyata terhadap Artemia salina serta berpotensi menjadi sumber senyawa bioaktif yang dapat dikembangkan lebih lanjut melalui pengujian farmakologi dan toksikologi lanjutan untuk memastikan efektivitas dan keamanannya.
Evaluasi Aktivitas Farmakologi Simplisia Kopi Arabika (Coffea arabica) pada Berbagai Konsentrasi terhadap Sistem Saraf Otonom dan Sistem Saraf Pusat Anggun Aldiansa; Ilmi Nurashiilah; Nahla Aulia Azis; Nasifa Kayla Putri; Andi Tenriani Awaliyah; Ayu Azkiya; Aulya Nurul Imama R; Hilda Kadir; Muhammad Chairul Anam; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2015

Abstract

Arabica coffee (Coffea arabica) contains various bioactive compounds such as caffeine, polyphenols, flavonoids, and alkaloids that have the potential to produce diverse pharmacological effects on both the autonomic and central nervous systems. The variation in its chemical composition is influenced by factors such as cultivar, post-harvest processing, and preparation methods, resulting in biological responses that are dose-dependent and not always linear. This study aimed to evaluate the pharmacological activity of arabica coffee simplicia powder at three concentrations (1%, 2%, and 4%) by observing parasympathomimetic, parasympatholytic, sympathomimetic, sympatholytic, analeptic, central nervous system stimulation and depression, as well as muscle relaxation parameters. The research was conducted using a laboratory experimental design with test animals administered orally according to the designated concentrations. The results showed that some parameters increased at higher concentrations, such as parasympathomimetic activity (51.85%) and central nervous system stimulation (63.74%), while other parameters demonstrated decreasing or biphasic patterns, such as sympatholytic activity, which was high at 1% and 4% but low at 2%, and analeptic activity, which dropped sharply at 2% and increased again at 4%. These response patterns align with literature indicating that caffeine and polyphenols such as chlorogenic acid may interact synergistically or antagonistically, generating complex pharmacological effects through mechanisms involving adenosine modulation, excitatory neurotransmitters, the enteric nervous system, as well as antioxidant and anti-inflammatory pathways. Overall, this study demonstrates that arabica coffee simplicia exhibits multipotential pharmacological activity, with responses strongly influenced by concentration and the composition of its bioactive compounds, thereby providing a basis for further research on the phytopharmaceutical potential of arabica coffee.
Co-Authors Andi Tenriani Awaliyah Andi Utari Prasetya Ningrum Anggun Aldiansa Aulya Nurul Imama R Ayu Azkiya Azzahra Ramadani Dhiva Rabiatul Maulia Haryanto Haryanto Hilda Kadir Ilmi Nurashiilah Muh. Yusuf Al-Habib Rachman Muhammad Chairul Anam Nahla Aulia Azis Nur Azizah Khairani Nur Sahra Nurul Izzatul Jannah