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Rahasia Rahasia
Universitas Muhammadiyah Makassar
Health Professions Nursing Public Health

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Profil Aktivitas Farmakologis Daun Pepaya Segar pada Sistem Saraf: Suatu Kajian Berdasarkan Perbedaan Konsentrasi Nurul Izzatul Jannah; Husnul Hatima; Dhiva Rabiatul Maulia; Nurazizah Khairani; Fauziah Zakilah; Rahasia Rahasia; Sisma Efendi; Nur Aulia; Muh.Yusuf Al Habib Rachman; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2010

Abstract

The extract of Carica papaya L. leaves contains phytochemical compounds such as flavonoids, alkaloids, phenolics, and saponins that play a role in biological activities, including antioxidants, anti-inflammatory, analgesic, and modulation of the nervous system. This study aims to evaluate the effects of fresh papaya leaf extract on the central nervous system (CNS) and autonomic nervous system based on varying extract concentrations. The study used test animals with treatment groups consisting of negative control, positive control, and extracts at concentrations of 4%, 8%, and 16%. Parameters observed included parasympathomimetic (PSM), parasympatholytic (PSL), sympathomimetic (SM), sympatholytic (SL), analeptic effects (ANA), CNS stimulation (SSSP), CNS depression (DSSP), and muscle relaxation (RO). The results showed that the 16% concentration produced the highest PSM activity (46.82%) and dominant CNS stimulation (38.59%), while DSSP and RO decreased at higher concentrations. This phenomenon indicates that increasing the extract concentration does not always enhance CNS depression, but rather leads to stimulation. These findings support the potential of papaya leaf extract as a neuroprotective and multifunctional agent. Further research is needed to confirm its molecular mechanisms and clinical effectiveness as a phytotherapy candidate.
Penentuan Nilai LC₅₀ Ekstrak Etanol 80% Daun Trembesi (Samanea saman (Jacq.) Merr.) Menggunakan Metode BSLT Haryanto Haryanto; Resky Aulifiyah Haswari.B; Aulya Nurul Imama R; Agung Nur Aqdi; Rahasia Rahasia; Ilmi Nurashilah; Alya Salsabila; Risya Nida Kaffyiah Sereang; Mawar Sahid
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 4 (2026): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i4.2353

Abstract

Samanea saman (Jacq.) Merr. leaves contain various secondary metabolites with potential biological activities; therefore, preliminary toxicity testing is necessary to evaluate their safety and bioactive potential. This study aimed to determine the Lethal Concentration 50 (LC₅₀) value of the 80% ethanol extract of Samanea saman leaves using probit analysis and to classify its toxicity level. An experimental study was conducted using the Brine Shrimp Lethality Test (BSLT) with Artemia salina Leach larvae as the test organism. The extract was tested at concentrations of 10, 100, 500, 1,000, and 5,000 ppm. Larval mortality was recorded after the incubation period, and the data were analyzed using probit analysis to determine the LC₅₀ value. The results showed that larval mortality increased with increasing extract concentration, reaching 18.42%, 23.33%, 45.83%, 70.83%, and 88.89%, respectively. Probit analysis revealed an LC₅₀ value of 301.72 mg/L (ppm). Based on the toxicity classification, this value falls into the moderately toxic category, indicating that the 80% ethanol extract of Samanea saman leaves exhibits toxic activity against Artemia salina larvae. These findings suggest that the extract has promising potential as a source of bioactive compounds and warrants further investigation, including the isolation and identification of active constituents, cytotoxicity evaluation, and safety assessment in more complex biological systems.
Co-Authors Agung Nur Aqdi Alya Salsabila Andi Utari Prasetya Ningrum Aulya Nurul Imama R Dhiva Rabiatul Maulia Fauziah Zakilah Haryanto Haryanto Husnul Hatima Ilmi Nurashilah Mawar Sahid Muh.Yusuf Al Habib Rachman Nur Aulia Nurazizah Khairani Nurul Izzatul Jannah Resky Aulifiyah Haswari.B Risya Nida Kaffyiah Sereang Sisma Efendi