Triyana Indah Purwati
Universitas Islam Indonesia

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Kenaikan C-Reactive Protein pada Remaja Gangguan Bipolar: A Systematic Review Ulil Albab Habibah; Satria Akbar Putra Asmara; Triyana Indah Purwati; Nisrina Nabila
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 5 No. 2 (2026): Mei 2026
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v5i2.7236

Abstract

The diagnosis of bipolar disorder (BD) in adolescents is often delayed due to reliance on subjective assessments, necessitating objective biomarkers such as C-reactive protein (CRP) to improve clinical accuracy. This systematic review aims to synthesize the latest findings on the role of CRP levels in adolescents with BD through analysis of various experimental studies. The systematic review was conducted in January 2026 through searches in Embase, PubMed, and ScienceDirect for studies from 2016 to 2025. Selection was performed according to PRISMA. Risk of bias was assessed using JBI Critical Appraisal Tools. A total of four experimental studies with a total of 3298 subjects met the criteria with low to moderate risk of bias. CRP levels in adolescents with Bipolar Disorder were found to be significantly elevated compared to the control group, especially during the symptomatic phase and periods of severe symptoms. CRP levels in adolescents with BD were found to be significantly elevated compared to healthy controls (p<0.001) and the anxiety disorder group, especially during the severe symptomatic phase. Additionally, high initial CRP levels significantly predicted longer recovery times (p=0.009). CRP is an effective state-dependent biomarker to support diagnostic accuracy, predict clinical course, and monitor the risk of cognitive decline in adolescents with BD.
sebuah HUBUNGAN DUKUNGAN KELUARGA DENGAN KEKAMBUHAN SKIZOFRENIA DI INDONESIA: TINJAUAN SISTEMATIS Ulil Albab Habibah; Satria Akbar Putra Asmara; Triyana Indah Purwati; Rina Hilmina
Jurnal Riset Kesehatan Vol 15 No 1 (2026): MAY 2026
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v15i1.14438

Abstract

Schizophrenia is a chronic mental disorder characterized by disturbances in perception, emotion, and thought processes, affecting approximately 24 million people worldwide. In Indonesia, more than 400,000 individuals are estimated to live with schizophrenia. Relapse remains a major challenge in disease management and is influenced by various psychosocial factors, including family support. A systematic review was conducted in December 2025 using PubMed, ScienceDirect, and Google Scholar to identify relevant studies published between 2021 and 2025. Study selection followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The risk of bias was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools. Sixteen cross-sectional studies involving a total of 1,093 participants met the inclusion criteria. The included studies demonstrated low to high risk of bias. Most studies reported a statistically significant association between family support and relapse prevention or medication adherence among patients with schizophrenia (p < 0.05). Family support plays a crucial role in reducing relapse among patients with schizophrenia in Indonesia. Family-based interventions should be strengthened as part of long-term treatment strategies to improve clinical outcomes.