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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Indonesian Journal of Global Health Research
Dedianto Hidajat
Universitas Mataram
Health Professions Medicine & Pharmacology

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Artikel Review : Potensi Ashitaba (Angelica keiskei) sebagai Alternatif Terapi di Bidang Dermatologi Naya Wahyu Anindiya; Dedianto Hidajat; Agriana Rosmalina Hidayati
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.30595

Abstract

Ashitaba ( Angelica keiskei ) merupakan tanaman asal Jepang yang telah banyak dibudidayakan di Indonesia. Penelitian tentang ashitaba sudah banyak berkembang dalam bidang dermatologi sehingga tinjauan pustaka ini bertujuan untuk melihat perkembangan potensi ashitaba sebagai terapi alternatif di bidang dermatologi. Metode penelusuran artikel yang digunakan yaitu penelusuran artikel ilmiah melalui database seperti Google Scholar, ResearchGate dan Proquest dalam rentang waktu 2014-2024. Hasil tinjauan pustaka menunjukkan ashitaba berpotensi menjadi pengobatan alternatif dalam bidang dermatologi karena mengandung bioaktif yang memiliki aktivitas antibakteri, antiinflamasi, antioksidan, menghambat enzim tirosinase dan mengurangi ukuran tumor melanoma. Namun, penelitian lebih lanjut secara in vivo diperlukan untuk terapi jerawat vulgaris, serta uji klinis pada manusia untuk terapi penyembuhan luka, penuaan dini, hiperpigmentasi, dan melanoma.
The Effect of Methotrexate as An Alternative Therapy in Cushing Syndrome Induced by Methylprednisolone in Multibacillary Morbus Hansen with Erythema Nodosum Leprosum Ni Komang Sri Adelia Cahya Ningrum; Ida Ayu Ista Nariswari; Dedianto Hidajat
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1956

Abstract

Long-term high-dose corticosteroid therapy in Erythema Nodosum Leprosum (ENL) and Multibacillary Morbus Hansen (MB-type MH) can cause side effects, one of which is Cushing's Syndrome. A 25-year-old male patient with ENL and MB-type MH experienced Cushing's Syndrome due to a history of treatment with oral methylprednisolone 32 mg/day for 1 year with supervision as a management of his disease. Management during hospitalization with Multidrug Treatment-Multibacillary (MDT-MB), methotrexate 25 mg/week, folic acid 1 mg/day and topical therapy in the form of 10% urea cream twice a day. After 4 days hospitalized, this patient's condition improved.  Methotrexate is a therapeutic option for ENL because of its anti-inflammatory mechanisms that specifically target the pathogenic pathways that cause ENL, especially inflammation and cytokine storm caused by neutrophils. Administration of methotrexate as an alternative therapy in treating ENL and MB-type MH with Cushing's syndrome can be considered.
Co-Authors Hidayati, Agriana Rosmalina Ida Ayu Ista Nariswari Naya Wahyu Anindiya Ni Komang Sri Adelia Cahya Ningrum