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All Journal TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Jurnal Ilmiah Kesehatan Masyarakat
Wiwit Probowati
Universitas ‘Aisyiyah Yogyakarta
Humanities Computer Science & IT Dentistry Engineering Health Professions Medicine & Pharmacology Nursing Public Health Veterinary Other

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Gambaran Hasil Pemeriksaan Genexpert pada Penderita Tuberkulosis Paru dengan Komplikasi di Rumah Sakit Panti Rapih Yogyakarta Adelia Amanda Puteri; Widaninggar Rahma Putri; Wiwit Probowati
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 4 No. 4 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v4i4.6835

Abstract

Pulmonary tuberculosis (TB) continues to pose a significant worldwide health concern, particularly when associated with complications. Delays in diagnosis and identification of drug resistance in these cases can increase morbidity and mortality. This descriptive analytical study using cross-sectional methodology aims to explain the results of GeneXpert examination, a rapid molecular diagnostic instrument, in patients with pulmonary tuberculosis with complications at Panti Rapih Hospital, Yogyakarta. In 2024, secondary data collection using a total sampling strategy, which included 660 patients with pulmonary and extrapulmonary tuberculosis, resulted in 132 cases of pulmonary tuberculosis and 32 samples that met the inclusion criteria. The findings showed that the sample was dominated by men (56.3%) of productive age (75%), with pleural effusion as the most common complication. The main GeneXpert finding was that more than half of the samples (59.4%) showed "MTB Detected Low" results that were sensitive to Rifampicin. This profile confirms the urgency of using GeneXpert as a rapid diagnostic tool to determine appropriate treatment strategies early, particularly in complex patients at high risk of therapy failure.
Pengaruh Penundaan Waktu Pemeriksaan Sputum GeneXpert Pada Pasien Suspek Tuberculosis di Salah Satu RS di Yogyakarta Abdul Arif Febrian Mahmud; Dhiah Novalina; Wiwit Probowati
TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Vol 7, No 3 (2026)
Publisher : Universitas Nurul Jadid

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33650/trilogi.v7i3.16758

Abstract

Tuberculosis (TB) remains a global health problem that requires rapid and accurate diagnosis to support treatment success and disease control. The GeneXpert MTB/RIF molecular assay is a recommended diagnostic method due to its ability to rapidly and sensitively detect Mycobacterium tuberculosis (MTB). Pre-analytical factors, including delays in sputum examination, may affect specimen quality and diagnostic results. This study aimed to determine the effect of delayed sputum examination on MTB detection using the GeneXpert MTB/RIF method. A quantitative, one-group paired pre-experimental design was conducted at the Microbiology Laboratory of a hospital in Yogyakarta. Seven sputum specimens from patients suspected of having tuberculosis who met the inclusion criteria were selected using purposive sampling. Each specimen was examined immediately (0 hours) and retested after a 6-hour delay at room temperature. The data were analyzed using the McNemar test with a significance level of 5%. The results showed identical MTB detection results at both examination times. Five specimens (71.4%) were negative and two specimens (28.6%) were positive at both 0-hour and 6-hour examinations. The McNemar test yielded a p-value of 1.00 (p > 0.05). No change in MTB detection was observed among the seven specimens after a 6-hour delay. Therefore, within the limitations of this study, no change in MTB detection results was observed following a 6-hour delay in sputum examination using the GeneXpert MTB/RIF method.
Co-Authors Abdul Arif Febrian Mahmud Adelia Amanda Puteri Dhiah Novalina Widaninggar Rahma Putri