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All Journal International Journal of Health, Engineering and Technology Sanitas: Journal of Health, Medical, and Psychological Studie
Alfina Nurrahman
Universitas Duta Bangsa
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Uji Potensi Fraksi n-Heksan Daun Keji Besi (Hemigraphis repanda L.) Sebagai Antibakteri Terhadap Escherichia Coli dan Bacillus Cereus Beserta Penentuan Konsentrasi Hambat Minimum (KHM) Alfina Nurrahman; Rahmat Hidayat; Annora Rizky Amalia
Journal of Health, Medical, and Psychological Studies Vol 1 No 2 (2025): December: Sanitas: Journal of Health, Medical, and Psychological Studies
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/29v9p164

Abstract

This study aimed to evaluate the antibacterial potential of the n-hexane fraction of Keji Besi leaves (Hemigraphis repanda L.) against Escherichia coli and Bacillus cereus, as well as to determine its Minimum Inhibitory Concentration (MIC). Keji Besi leaves were extracted by maceration using 96% ethanol, followed by liquid–liquid fractionation with n-hexane. The antibacterial activity was assessed using the disc diffusion method, while MIC values were determined using the broth dilution method. Phytochemical screening revealed that the n-hexane fraction predominantly contained steroid and triterpenoid compounds. The disc diffusion assay showed that the n-hexane fraction exhibited stronger inhibitory activity against B. cereus than E. coli, with the largest inhibition zone observed at an 80% concentration. MIC determination indicated that the MIC value for B. cereus was 40% (w/v), whereas E. coli required a higher concentration of 80% (w/v) to inhibit bacterial growth. These findings suggest that the n-hexane fraction of Keji Besi leaves demonstrates selective antibacterial activity, particularly against Gram-positive bacteria. Therefore, this fraction has promising potential to be developed as a natural antibacterial agent, especially for infections caused by Gram-positive pathogens.
The Effect Of Variations In The Concentration Of Ethanol Extract Of Green Okra Fruit (Abelmoschus Esculentus L. Moench) On The Antioxidant Activity Of Face Mist Preparations Using The DPPH Method Sirna Dzawil Kamala; Alfina Nurrahman; Kharisma Jayak Pratama
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.613

Abstract

Skin aging due to oxidative stress from free radicals from UV exposure and pollution requires natural antioxidants in topical products. Ethanol extract from green okra fruit (Abelmoschus esculentus L. Moench) rich in phenolics has strong potential to capture DPPH. This quantitative preclinical experimental study aims to test the effect of extract concentration (3%, 6%, 9%) on antioxidant activity and physical quality of face mist preparations. The population of face mist preparations; purposive samples include controls and three formulas with three replications. UV-Vis spectrophotometer instruments for IC50 DPPH at 516 nm (operating time 15 minutes), pH meter, Brookfield viscometer. Descriptive and inferential analysis One-Way ANOVA and Tukey HSD (SPSS, p <0.05). The results showed IC50: control 71.92 ppm (strong), Formula I 146.75 ppm (moderate), II 80.63 ppm (strong), III 78.72 ppm (strong); pH 4.57-5.15 (skin compatible); viscosity 1.22-3.75 mPa.s (meets <5 mPa.s); homogeneous. High concentrations significantly increase antioxidant activity (p<0.05). In conclusion, the 9% formula of optimized strong antioxidant face mist meets cosmetic standards, with anti-aging potential.
Co-Authors Amalia, Annora Rizky Kharisma Jayak Pratama Rahmat Hidayat Sirna Dzawil Kamala