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All Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) Medfarm: Jurnal Farmasi dan Kesehatan Eureka Herba Indonesia Prosiding Seminar Informasi Kesehatan Nasional Scientific Journal of Dermatology and Venereology Crown: Journal of Dentistry and Health Research (MJN)
Amalia, Annora Rizky
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Potential of Ethanol Extract of Red Gedi Leaves (Abelmoschus manihot L. Medik) Against Endogenous Antioxidant Activity in Rat Model of Diabetes Mellitus Amalia, Annora Rizky; Alfina Nurrahman; Dewi Weni Sari; Muhammad Firdaus
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.123

Abstract

Diabetes mellitus (DM) is characterized by chronic hyperglycemia and increased oxidative stress, contributing to disease complications. Red gedi leaves (Abelmoschus manihot L. Medik) are rich in bioactive compounds, including tannins, saponins, alkaloids and flavonoids, with antioxidant potential. This study aims to evaluate the effect of ethanol extract of red gedi leaves on endogenous antioxidant activity in rat model of DM induced by STZ-NA. Male rats were induced with DM with streptozotocin (STZ)-NA. Rats were divided into five groups: normal control (KN), DM control (KDM), glibenclamide positive control (KPG), and group treated with red gedi leaf extract at a dose of 100 mg/kgBW (GEDI 100), 200 mg/kgBW (GEDI 200), and 400 mg/kgBW (GEDI 400). The parameters observed included blood glucose levels, malondialdehyde (MDA) as a marker of oxidative stress, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue. Data analysis used one-way ANOVA and Tukey's post hoc test (p<0.05). The results showed that the yield of ethanol extract from red gedi leaves was 6.984%. Administration of red gedi leaf extract at a dose of 400 mg/kgBW (GEDI 400) significantly reduced blood glucose levels (p<0.05) and MDA (p<0.05), and increased the activity of SOD (p<0.05), CAT (p<0.05), and GPx (p<0.05) in DM rats compared to the DM control group (KDM). The effect of GEDI 400 was comparable to the effect of glibenclamide as a positive control. The ethanol extract of red gedi leaves at a dose of 400 mg/kgBW was effective in increasing endogenous antioxidant activity and reducing oxidative stress in STZ-NA-induced DM rats, showing potential as an antioxidant and antidiabetic agent.
Antibacterial Test of Cherry Leaves Ethanol Extract (Muntingia calabura L.) Against Streptococcus mutans Amalia, Annora Rizky; Riyan Setiyanto; Alfina Nurrahman; Ariska Rahmawati Utami; Dewi Weni Sari
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.128

Abstract

Introduction: Streptococcus mutans is a bacteria that plays an important role in the occurrence of dental caries. Use of antibiotics to treat infections Streptococcus mutans often causes side effects. Cherry leaves (Muntingia calabura L.) contain active compounds that have the potential to have antibacterial effects. This research aims to determine the inhibitory power of cherry leaf ethanol extract against Streptococcus mutans in vitro. Methods: This research uses an experimental method with a post-test-only control group design. Cherry leaf ethanol extract was made by maceration method using 96% ethanol solvent for 5 days. The antibacterial test was carried out using the paper disc diffusion method with varying concentrations of cherry leaf extract, namely 20%, 40%, and 60% w/v dissolved in 10% DMSO. The positive control used was the amoxicillin antibiotic disc, while the negative control used 10% DMSO. Results: The results of the antibacterial test of the ethanol extract of cherry leaves in this study showed that at a concentration of 20% it had an average inhibitory power of 9.16 mm, the extract with a concentration of 40% had an inhibitory power of 11.33 mm, and at a concentration of 60% it had an inhibitory power of 12. 16mm. The positive control amoxicillin had an inhibitory power of 18.67 mm. Conclusion: Cherry leaf ethanol extract has potential as an alternative therapy to overcome Streptococcus mutans bacterial infections.
Antibacterial Activity of Ethanol Extract of Srikaya Leaves (Annona squamosa Linn) Against the Growth of Acne Vulgaris-Causing Bacteria Staphylococcus epidermidis Amalia, Annora Rizky; Zulaika Febru Zalsabila; Yunita Dian Permata Sari
Scientific Journal of Dermatology and Venereology Vol. 3 No. 1 (2025): Scientific Journal of Dermatology and Venereology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjdv.v2i2.143

Abstract

Introduction: Acne vulgaris, a prevalent skin condition, is primarily triggered by the proliferation of Cutibacterium acnes within pilosebaceous units. However, Staphylococcus epidermidis, a commensal skin bacterium, can exacerbate acne inflammation upon follicular invasion. This study investigates the antibacterial potential of ethanol extract derived from srikaya leaves (Annona squamosa Linn) against S. epidermidis. Methods: Srikaya leaves underwent ethanol extraction via maceration. The extract's antibacterial efficacy was assessed using the agar well diffusion method against S. epidermidis at varying concentrations (25%, 50%, 75%). Zones of inhibition were measured, and minimum inhibitory concentrations (MICs) were determined. Phytochemical screening of the extract was conducted to identify potential bioactive compounds. Results: The ethanol extract of srikaya leaves exhibited significant antibacterial activity against S. epidermidis. Increasing extract concentrations led to larger zones of inhibition, indicating a dose-dependent effect. The MIC of the extract against S. epidermidis was determined to be 50%. Phytochemical analysis revealed the presence of flavonoids, phenols, and alkaloids, which are known for their antimicrobial properties. Conclusion: Ethanol extract of srikaya leaves demonstrates promising antibacterial activity against S. epidermidis, suggesting its potential as a natural therapeutic agent for managing acne vulgaris. Further research is warranted to elucidate the mechanisms of action and evaluate the extract's efficacy in clinical settings.
AN ANALYSIS OF DRUG INVENTORY CONTROL EFFICIENCY USING ALWAYS BETTER CONTROL, VITAL ESSENTIAL NON-ESSENTIAL, AND ECONOMIC ORDER QUANTITY METHODS: A CASE STUDY AT ASSALAAM MEDICARE Arief, Khunaisa; Nafisah, Umi; Amalia, Annora Rizky
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.578

Abstract

In-depth control of pharmaceutical inventory is critical, especially in healthcare facility units to ensure the availability of drugs to minimize the risk of stagnation (excess inventory of drugs) and inventory vacancies (shortage or empty level of inventory). The purpose of this study is to determine how inventory level control is carried out at Assalaam Medicare pharmacy using the ABC (Always, Better, Control), VEN (Vital, Essential, Non Essential), and EOQ (Economic Order Quantity) methods for the period January to March 2024. Based on ABC analysis of a total of 572 items of drugs, 151 items of drugs are classified into group A which accounts for 27.970 or 65%, with an investment value of 75% of the total, group B with 215 drug items with a consumption of 10,236 or 24% and an investment of 20%, and group C with 206 items which has a consumption of 4,521 or 11% and an investment of 6%. From the VEN analysis, 26 drug items belong to the vital (V) drug class of group A as an essential service segment. According to EOQ, the highest optimum order quantity is 2.061 items and the lowest optimum value is 17 items for a single order.
IDENTIFIKASI SENYAWA FITOKIMIA EKSTRAK DAUN MIANA (COLEUS ATROPURPUREUS L. BENTH) Nurrahman, Alfina; Amalia, Annora Rizky
Prosiding Seminar Informasi Kesehatan Nasional 2025: SIKesNas 2025
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/vdhxvf11

Abstract

Penelitian ini bertujuan untuk mengidentifikasi kandungan fitokimia dari ekstrak etanol daun miana dengan pengujian organoleptis, kadar air, bebas alkohol, serta uji fitokimia kualitatif. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 70%. Hasil menunjukkan bahwa ekstrak memiliki karakteristik organoleptis berwarna ungu tua, berbau khas aromatik, dan berbentuk kental. Kadar air ekstrak menunjukkan nilai 7,48 %, uji bebas alkohol menunjukkan hasil negatif, serta hasil uji fitokimia kualitatif menunjukkan adanya senyawa alkaloid, flavonoid, tanin, dan steroid. Hasil ini menunjukkan bahwa ekstrak etanol daun miana mengandung senyawa bioaktif yang potensial untuk dikembangkan dalam pengobatan herbal.
UJI KONSENTRASI HAMBAT MINIMUM (KHM) MINYAK ATSIRI ADAS (FOENICULUM VULGARE MILL.) TERHADAP PERTUMBUHAN BAKTERI PROPIONIBACTERIUM ACNES DENGAN METODE SUMURAN Amalia, Annora Rizky
Jurnal Review Pendidikan dan Pengajaran Vol. 7 No. 3 (2024): Vol. 7 No. 3 (2024): Volume 7 No 3 Tahun 2024 (Special Issue)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jrpp.v7i3.32115

Abstract

Jerawat (acne vulgaris) merupakan suatu kondisi inflamasi yang secara umum terjadi pada bagian organ kulit. Jerawat dapat disebabkan oleh bakteri Staphylococcus aureus, Propionibacterium acnes dan Staphylococcus epidermidis. Penelitian ini bertujuan untuk mengetahui aktivitas minyak atsiri adas (foeniculum vulgare mill.) terhadap pertumbuhan bakteri propionibacterium acnes. Pengujian aktivitas antibakteri dilakukan menggunakan metode difusi agar dengan cara sumuran pada variasi konsentrasi 2%, 4%, 6% dan 8% . Kontrol positif yang digunakan pada penelitian ini adalah klindamisin dan kontrol negatif menggunakan DMSO 10%. Hasil uji daya hambat yang diperoleh dari pengujian minyak adas pada konsentrasi 2% memiliki daya hambat rata-rata 7,5mm, konsentrasi 4% memiliki daya hambat rata-rata 12 mm, konsentrasi 6% memiliki daya hambat rata-rata 17 mm, dan pada konsentrasi 8% memiliki daya hambat rata-rata 19 mm. Kontrol positif klindamisin memiliki daya hambat sebesar 14 mm maka disimpulkan bahwa Konsentrasi Hambat Minimum (KHM) minyak atsiri adas terhadap bakteri jerawat yaitu Propionibacterium acnes pada konsentrasi 2% dengan diameter zona hambat sebesar 7,5 mm.
COST OF ILLNESS STROKE TREATMENT: A SYSTEMATIC REVIEW Izzah, Raihana Nurul; Alia, Dina Fatma; Amalia, Annora Rizky; Sari, Yunita Dian Permata
Medical Journal of Nusantara Vol. 5 No. 1 (2026): Medical Journal of Nusantara (MJN)
Publisher : Tahta Media Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55080/mjn.v5i1.1957

Abstract

Cardiovascular disease remains the leading cause of death worldwide, with stroke playing a significant role in increasing morbidity, mortality, and the global economic burden. This study aimed to systematically review the cost of illness and health expenditure associated with stroke across different countries. A systematic review was conducted using PubMed, ScienceDirect, and Springer databases for articles published between 2021 and 2026, following PRISMA guidelines. Studies included in the criteria were original research that reported direct and/or indirect costs due to stroke, both in primary health care facilities and in hospitals. Data extraction, screening, and quality assessment were performed using the CHEERS checklist. A total of 13 studies met the inclusion criteria. The findings showed that most studies (76%) applied the Cost Of Illness (COI) approach, while the rest used Health Expenditure (HE) methods. Direct medical costs, particularly those from inpatient care, constitute the largest component of stroke-related expenditures. Cost estimates show considerable variation between countries, with expenditures tending to be higher in high-income countries than in middle-income countries. Clinical severity, length of hospital stay, stroke subtype, and sociodemographic factors were identified as key determinants influencing total costs. Indirect cost components such as lost productivity and premature death also contribute significantly, but their reporting has not been consistent across studies. In conclusion, stroke imposes a substantial and heterogeneous economic burden influenced by methodological approaches, perspectives, and healthcare system differences. Comprehensive evaluation including both direct and indirect costs is essential to support effective health policy and resource allocation.
Co-Authors Alfina Nurrahman Alia, Dina Fatma Arief, Khunaisa Ariska Rahmawati Utami Dewi Weni Sari Izzah, Raihana Nurul Muhammad Firdaus Nafisah, Umi Nurrahman, Alfina Riyan Setiyanto Sari, Yunita Dian Permata Yunita Dian Permata Sari Zulaika Febru Zalsabila