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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Ners Pediatric Sciences Journal Eduvest - Journal of Universal Studies
ADAM, OLIVIA MAHARDANI
Fakultas Kedokteran Universitas Hang Tuah
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Bell's Palsy Adam, Olivia Mahardani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 1 (2019): EDISI MARET 2019 (available online since April 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (941.311 KB) | DOI: 10.30742/jikw.v8i1.526

Abstract

Bell?s palsy didefinisikan sebagai kelumpuhan saraf fasialis satu sisi, dengan penyebabnya tidak diketahui. Beberapa keadaan lain juga dapat menyebabkan kelumpuhan fasialis, misalnya tumor otak, stroke, myasthenia gravis, dan penyakit Lyme. Namun, jika tidak ada penyebab khusus yang dapat diidentifikasi, kondisi ini dikenal sebagai Bell?s palsy yang disebabkan akibat pembengkakan dan tekanan saraf pada foramen stylomastoid dan menyebabkan penghambatan atau kerusakan saraf. Seringkali mata di sisi yang terkena tidak dapat ditutup, lipatan nasolabial dan garis dahi menghilang. Kortikosteroid ditemukan untuk memperbaiki hasil ketika digunakan lebih awal, sementara obat anti-virus belum. Banyak yang menunjukkan tanda perbaikan 10 hari setelah onset, bahkan tanpa pengobatan. Artikel ini bertujuan untuk mengulas Bell?s palsy terutama patofisiologinya. Tingkat keparahannya syaraf menentukan proses penyembuhan Bell?s palsy. 
Profil Pasien Morbus Hansen di Poliklinik Kulit dan Kelamin Rspal dr. Ramelan Periode 2016–2021 Mahaputra, Putu Wahyu; Apriano, Putu Pradika; Dianawati, Putu Sri Ayu Yulian; Adi, R. Gery Susianggara Purnama; Manusakti, Raditya; Prameswari, Renata; Adam, Olivia Mahardani
Jurnal Ners Vol. 7 No. 2 (2023): OKTOBER 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v7i2.16826

Abstract

Morbus Hansen is an infectious skin disease caused by Mycobacterium Leprosy which besomes one of the neglected disease and very common in Indonesia and other subtropical countries. World Health Organization (WHO) reported the number of new cases of Hansen's disease on 2018 in 159 countries was 208,619 cases. Indonesia ranks third in the world with a total of 17,017 cases, after India and Brazil. On this retrospective descriptive study regarding the profile of Morbus Hansen patients at the Dernatovenerology Clinic, dr. Ramelan Hospital on 2016–2021, there were 24 Morbus Hansen patients registered at the RSPAL Dr. Skin and Venereology Polyclinic. Ramelan during 2016-2021. The prevalence of Morbus Hansen is dominant in male patients, with a ratio of 5:1 compared to female patients, the avarage age of the groups is 21-30 years and 41-50 years. Based on the type of morbus hansen, 87,5% were Multibacillary (MB) type.
Patent ductus arteriosus and pulmonary hypertension in a fifteen-year-old boy with congenital rubella syndrome and cerebral palsy: a case report Putri, Jeanaya Hedya Alfara; Haris, Ivana Angelica; Nahdah, Jaudah; Putri, Jenniefer Clarissa; Hamdy, Irza Hasanal; Pikir, Rizqi Rokhmadhoni; Adam, Olivia Mahardani; Adiwinoto, Ronald Pratama
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.96

Abstract

Introduction: Congenital Rubella Syndrome (CRS) is characterized by congenital cataracts, congenital heart disease (CHD), hearing loss, and developmental delay. It is caused by maternal rubella infection during pregnancy, transmitted transplacentally or via respiratory droplets. CRS carries a high risk of morbidity and mortality, with approximately 10–20% of affected infants dying within the first year of life. This case report describes a 15-year-old boy with CRS who developed pulmonary hypertension (PH) due to a persistent patent ductus arteriosus (PDA). Case Description: A 15-year-old boy presented with progressive abdominal distension over one week. Initially suspected of having nephritic syndrome, further evaluation revealed bilateral congenital cataracts, non-cyanotic CHD in the form of PDA, sensorineural hearing loss, and developmental delay, fulfilling criteria for CRS. The patient also exhibited delayed motor milestones (walking at age seven) and limb rigidity suggestive of cerebral palsy (CP). Echocardiography confirmed PDA (0.4 cm) with severe tricuspid and aortic regurgitation, and chest X-ray demonstrated cardiomegaly with PH. The PDA was successfully closed using an Amplatzer Duct Occluder (ADO) via catheterization. Conclusion: This case underscores the importance of early diagnosis and intervention in CRS patients with PDA to prevent irreversible pulmonary vascular disease. Despite a very late PDA closure at age 15, the patient achieved hemodynamic improvement and maintained functional capacity, highlighting that catheter-based closure remains feasible and beneficial even in adolescence. Multidisciplinary care, including timely cardiac intervention and neurodevelopmental support, can improve quality of life in CRS survivors.
The In silico Study: Curcumin Potential As A Topoisomerase Enzyme Inhibitor in The Replication Process of Plasmodium Falciparum That Causes Cerebral Malaria Safitri, Any Fira; Risma, Risma; Adam, Olivia Mahardani; Danandjaja, Danny W.
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50044

Abstract

Turmeric (Curcuma longa) contains the active compound curcumin, which has antiprotozoal, antimalarial, anti-inflammatory effects. This study aims to ignite the potential of curcumin, which has the potential as an antiprotozoal through inhibition of Plasmodium Falciparim replication through the topoisomerase enzyme. The method used in this study is the One Shot Experimental Study, with several stages including preparation of active compounds, prediction of active substance binding energy, prediction of compound binding, molecular docking, prediction of ADME (absorption, distribution, metabolism, excretion) and toxicity. The results show that curcumin binds to the same site as Artemisinin, both also interact with the topoisomerase VI protein and provide similar inhibitory effects. ADME predictions show that curcumin has good potential for use as an oral drug, with both LD50s included in class 4. The binding affinity and bioactivity of curcumin are lower than Artemisinin but are still considered to have the potential as a safer antiprotozoal alternative.
Co-Authors Adi, R. Gery Susianggara Purnama Apriano, Putu Pradika Danandjaja, Danny W. Dewi, Lestari Dianawati, Putu Sri Ayu Yulian HAFSOH, TSALAIS YUNA Hamdy, Irza Hasanal Haris, Ivana Angelica Mahaputra, Putu Wahyu Manusakti, Raditya Nahdah, Jaudah Pikir, Rizqi Rokhmadhoni Putri, Jeanaya Hedya Alfara Putri, Jenniefer Clarissa Renata Prameswari Risma Risma, Risma Ronald Pratama Adiwinoto Safitri, Any Fira TEHUPURING, SIHNING EJ YULIAN, KENNY