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Atrial Septal Defect Hakim, An Nahl Aulia; Adnaya, Anak Agung Ngurah Maheza; Prasetyo, Ananda Bangun; Pikir, Rizqi Rokhmadhoni; Diarsvitri, Wienta; Suhadi, Ananda Rizki; Dita, Anastasia
Surabaya Biomedical Journal Vol 4 No 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.147

Background: Atrial Septal Defect (ASD) is one of the most common congenital heart diseases, occurring in about 25% of children and accounting for 6-10% of all congenital heart conditions. ASD is more frequently observed in females with a ratio of 2:1 and often does not show symptoms in infants, unless there is an increase in right ventricular volume. Case Report: A 7-year-old girl was referred with complaints of shortness of breath and cyanosis at the fingertips, accompanied by palpitations. Initial diagnosis was established through physical examination and echocardiography, which revealed a secundum ASD measuring 1.9 cm. The ASD closure surgery was performed but had to be halted due to intraoperative bradycardia. The patient then underwent subsequent therapy with Lisinopril and Spironolactone and was in good condition at the last follow-up. Discussion: Management of ASD, whether through surgical or catheter-based intervention, is recommended to prevent further complications such as paradoxical embolism and pulmonary hypertension. This case underscores the importance of timely diagnosis and treatment to prevent long-term health impacts in patients with ASD.

Atrial Septal Defect Hakim, An Nahl Aulia; Adnaya, Anak Agung Ngurah Maheza; Prasetyo, Ananda Bangun; Pikir, Rizqi Rokhmadhoni; Diarsvitri, Wienta; Suhadi, Ananda Rizki; Dita, Anastasia
Surabaya Biomedical Journal Vol. 4 No. 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.147

Background: Atrial Septal Defect (ASD) is one of the most common congenital heart diseases, occurring in about 25% of children and accounting for 6-10% of all congenital heart conditions. ASD is more frequently observed in females with a ratio of 2:1 and often does not show symptoms in infants, unless there is an increase in right ventricular volume. Case Report: A 7-year-old girl was referred with complaints of shortness of breath and cyanosis at the fingertips, accompanied by palpitations. Initial diagnosis was established through physical examination and echocardiography, which revealed a secundum ASD measuring 1.9 cm. The ASD closure surgery was performed but had to be halted due to intraoperative bradycardia. The patient then underwent subsequent therapy with Lisinopril and Spironolactone and was in good condition at the last follow-up. Discussion: Management of ASD, whether through surgical or catheter-based intervention, is recommended to prevent further complications such as paradoxical embolism and pulmonary hypertension. This case underscores the importance of timely diagnosis and treatment to prevent long-term health impacts in patients with ASD.

Patent ductus arteriosus and pulmonary hypertension in a fifteen-year-old boy with congenital rubella syndrome and cerebral palsy: a case report Putri, Jeanaya Hedya Alfara; Haris, Ivana Angelica; Nahdah, Jaudah; Putri, Jenniefer Clarissa; Hamdy, Irza Hasanal; Pikir, Rizqi Rokhmadhoni; Adam, Olivia Mahardani; Adiwinoto, Ronald Pratama
Pediatric Sciences Journal Vol. 6 No. 1 (2025): Available online : 1 June 2025
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v6i1.96

Introduction: Congenital Rubella Syndrome (CRS) is characterized by congenital cataracts, congenital heart disease (CHD), hearing loss, and developmental delay. It is caused by maternal rubella infection during pregnancy, transmitted transplacentally or via respiratory droplets. CRS carries a high risk of morbidity and mortality, with approximately 10–20% of affected infants dying within the first year of life. This case report describes a 15-year-old boy with CRS who developed pulmonary hypertension (PH) due to a persistent patent ductus arteriosus (PDA). Case Description: A 15-year-old boy presented with progressive abdominal distension over one week. Initially suspected of having nephritic syndrome, further evaluation revealed bilateral congenital cataracts, non-cyanotic CHD in the form of PDA, sensorineural hearing loss, and developmental delay, fulfilling criteria for CRS. The patient also exhibited delayed motor milestones (walking at age seven) and limb rigidity suggestive of cerebral palsy (CP). Echocardiography confirmed PDA (0.4 cm) with severe tricuspid and aortic regurgitation, and chest X-ray demonstrated cardiomegaly with PH. The PDA was successfully closed using an Amplatzer Duct Occluder (ADO) via catheterization. Conclusion: This case underscores the importance of early diagnosis and intervention in CRS patients with PDA to prevent irreversible pulmonary vascular disease. Despite a very late PDA closure at age 15, the patient achieved hemodynamic improvement and maintained functional capacity, highlighting that catheter-based closure remains feasible and beneficial even in adolescence. Multidisciplinary care, including timely cardiac intervention and neurodevelopmental support, can improve quality of life in CRS survivors.

Pengaruh Spirulina platensis terhadap Aktivitas Katalase Hepar Tikus (Rattus Norvegicus) yang Diinduksi Parasetamol Dosis Tinggi Hapsari, Sindy Arum; E. J. T., Sihning; Pikir, Rizqi Rokhmadhoni; Pratiknya, Djatiwidodo Edi
Jurnal Kedokteran Meditek Vol 29 No 3 (2023): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v29i3.2758

Drug-Induced Liver Injury (DILI), seringkali disebabkan oleh akumulasi metabolit reaktif yang dihasilkan obat seperti parasetamol, N-acetyl-p-benzoqui-none imine (NAPQI) sehingga memicu terjadinya stres oskidatif, yaitu kondisi dimana perbandingan jumlah radikal bebas yang lebih tinggi daripada jumlah antioksidan. Ekstrak Spirulina platensis (S. platensis) yang kaya antioksidan berpotensi menangkal radikal bebas. Peneliti terdahulu menunjukkan S. platensis 360 mg/KgBB dapat menurunkan malondialdehida sebagai indikator kadar radikal bebas. Oleh karena itu, penelitian ini dilakukan uji aktivitas katalase untuk mengetahui peran S. platensis 360 mg/KgBB sebagai indikator kadar antioksidan pada kondisi stres oksidatif. Penelitian dilakukan dengan randomized posttest only control group design. Sampel sebanyak 30 ekor tikus Rattus norvegicus jantan, dibagi menjadi 3 kelompok: (K-) kelompok yang tidak mendapat perlakuan; (K+) kelompok yang diinduksi parasetamol; (Kp) kelompok yang diinduksi parasetamol dan diberi ekstrak S. platensis 360 mg/KgBB. Pada akhir penelitian, seluruh kelompok dilakukan perhitungan aktivitas katalase jaringan hepar. Hasil uji One Way Anova menunjukkan adanya peningkatan aktivitas katalase yang signifikan (p = 0,041), terutama antara kelompok K- dengan kelompok K+ (p = 0,032) dan antara kelompok Kp dengan kelompok K+ (p = 0,025). Simpulan penelitian menunjukkan bahwa ekstrak S. platensis terbukti memberikan pengaruh antioksidan terhadap peningkatan aktivitas katalase jaringan hepar tikus yang diinduksi parasetamol dosis tinggi.

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