Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Surabaya Biomedical Journal Jurnal Kedokteran Meditek Surabaya Biomedical Journal
Pikir, Rizqi Rokhmadhoni
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Atrial Septal Defect Hakim, An Nahl Aulia; Adnaya, Anak Agung Ngurah Maheza; Prasetyo, Ananda Bangun; Pikir, Rizqi Rokhmadhoni; Diarsvitri, Wienta; Suhadi, Ananda Rizki; Dita, Anastasia
Surabaya Biomedical Journal Vol 4 No 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.147

Abstract

Background: Atrial Septal Defect (ASD) is one of the most common congenital heart diseases, occurring in about 25% of children and accounting for 6-10% of all congenital heart conditions. ASD is more frequently observed in females with a ratio of 2:1 and often does not show symptoms in infants, unless there is an increase in right ventricular volume. Case Report: A 7-year-old girl was referred with complaints of shortness of breath and cyanosis at the fingertips, accompanied by palpitations. Initial diagnosis was established through physical examination and echocardiography, which revealed a secundum ASD measuring 1.9 cm. The ASD closure surgery was performed but had to be halted due to intraoperative bradycardia. The patient then underwent subsequent therapy with Lisinopril and Spironolactone and was in good condition at the last follow-up. Discussion: Management of ASD, whether through surgical or catheter-based intervention, is recommended to prevent further complications such as paradoxical embolism and pulmonary hypertension. This case underscores the importance of timely diagnosis and treatment to prevent long-term health impacts in patients with ASD.
Atrial Septal Defect Hakim, An Nahl Aulia; Adnaya, Anak Agung Ngurah Maheza; Prasetyo, Ananda Bangun; Pikir, Rizqi Rokhmadhoni; Diarsvitri, Wienta; Suhadi, Ananda Rizki; Dita, Anastasia
Surabaya Biomedical Journal Vol. 4 No. 1 (2024): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i1.147

Abstract

Background: Atrial Septal Defect (ASD) is one of the most common congenital heart diseases, occurring in about 25% of children and accounting for 6-10% of all congenital heart conditions. ASD is more frequently observed in females with a ratio of 2:1 and often does not show symptoms in infants, unless there is an increase in right ventricular volume. Case Report: A 7-year-old girl was referred with complaints of shortness of breath and cyanosis at the fingertips, accompanied by palpitations. Initial diagnosis was established through physical examination and echocardiography, which revealed a secundum ASD measuring 1.9 cm. The ASD closure surgery was performed but had to be halted due to intraoperative bradycardia. The patient then underwent subsequent therapy with Lisinopril and Spironolactone and was in good condition at the last follow-up. Discussion: Management of ASD, whether through surgical or catheter-based intervention, is recommended to prevent further complications such as paradoxical embolism and pulmonary hypertension. This case underscores the importance of timely diagnosis and treatment to prevent long-term health impacts in patients with ASD.
Pengaruh Spirulina platensis terhadap Aktivitas Katalase Hepar Tikus (Rattus Norvegicus) yang Diinduksi Parasetamol Dosis Tinggi Hapsari, Sindy Arum; E. J. T., Sihning; Pikir, Rizqi Rokhmadhoni; Pratiknya, Djatiwidodo Edi
Jurnal Kedokteran Meditek Vol 29 No 3 (2023): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v29i3.2758

Abstract

Drug-Induced Liver Injury (DILI), seringkali disebabkan oleh akumulasi metabolit reaktif yang dihasilkan obat seperti parasetamol, N-acetyl-p-benzoqui-none imine (NAPQI) sehingga memicu terjadinya stres oskidatif, yaitu kondisi dimana perbandingan jumlah radikal bebas yang lebih tinggi daripada jumlah antioksidan. Ekstrak Spirulina platensis (S. platensis) yang kaya antioksidan berpotensi menangkal radikal bebas. Peneliti terdahulu  menunjukkan S. platensis 360 mg/KgBB dapat menurunkan malondialdehida sebagai indikator kadar radikal bebas.  Oleh karena itu, penelitian ini dilakukan uji aktivitas katalase untuk mengetahui peran S. platensis 360 mg/KgBB sebagai indikator kadar antioksidan pada kondisi stres oksidatif. Penelitian dilakukan dengan randomized posttest only control group design. Sampel sebanyak 30 ekor tikus Rattus norvegicus jantan, dibagi menjadi 3 kelompok: (K-) kelompok yang tidak mendapat perlakuan; (K+) kelompok yang diinduksi parasetamol; (Kp) kelompok yang diinduksi parasetamol dan diberi ekstrak S. platensis 360 mg/KgBB. Pada akhir penelitian, seluruh kelompok dilakukan perhitungan aktivitas katalase jaringan hepar. Hasil uji One Way Anova menunjukkan adanya peningkatan aktivitas katalase yang signifikan (p = 0,041), terutama antara kelompok K- dengan kelompok K+ (p = 0,032) dan antara kelompok Kp dengan kelompok K+ (p = 0,025). Simpulan penelitian menunjukkan bahwa ekstrak S. platensis terbukti memberikan pengaruh antioksidan terhadap peningkatan aktivitas katalase jaringan hepar tikus yang diinduksi parasetamol dosis tinggi.
Co-Authors Adnaya, Anak Agung Ngurah Maheza Dita, Anastasia E. J. T., Sihning Hakim, An Nahl Aulia Hapsari, Sindy Arum Prasetyo, Ananda Bangun Pratiknya, Djatiwidodo Edi Suhadi, Ananda Rizki Wienta Diarsvitri