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KIETTIPUM PHONTREE
Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University. Khon Kaen 40002, Thailand
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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Evaluation of non-timber forest products used as medicinal plants from East Kalimantan (Indonesia) to inhibit ?-glucosidase and free radicals RICO RAMADHAN; RAMADHAN TOSEPU; PREECHA PHUWAPRAISIRISAN; RUDIANTO AMIRTA; KIETTIPUM PHONTREE; YAZDANIYAR FAJRI HALIMI FIRDAUS; NURLITA ABDULGANI; MUHAMMAD ZAINUL MUTTAQIN; SAPARWADI SAPARWADI
Biodiversitas Journal of Biological Diversity Vol. 23 No. 11 (2022)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d231102

Abstract

Abstract. Ramadhan R, Tosepu R, Phuwapraisirisan P, Amirta R, Phontree K, Firdaus YFH, Abdulgani N, Muttaqin MZ, Saparwardi. 2022. Evaluation of non-timber forest products used as medicinal plants from East Kalimantan (Indonesia) to inhibit ?-glucosidase and free radicals. Biodiversitas 23: 5551-5558. Non-timber forest products (NTFPs) have essential uses as medicines, food sources, and traditional ceremonies for the local people living in forest areas. Medicinal plants are one of the non-timber forest products used as traditional medicine by local people in East Kalimantan. This study was conducted to search for new natural antidiabetic and antioxidant resources from medicinal plants used traditionally in Mahakam Ulu District, East Kalimantan, based on ethnopharmacological information. The present study evaluates non-timber forest products as in vitro antidiabetic (rat intestinal ?-glucosidase inhibitory activity) and antioxidant (free radical scavenging activity against DPPH, ABTS, and Nitric Oxide) activities. The antidiabetic and antioxidant activities were evaluated using ?-glucosidase inhibition assay and free radical scavenging methods. This study demonstrated that methanol extracts of Flacourtia rukam Zoll. & Moritzi, Syzygium chloranthum (Duthie) Merr. & L.M. Perry and Shorea balangeran Burck exhibited strong ?-glucosidase inhibitory activity with maltose as a substrate with IC50 values of 0.034 mg/mL, 0.039 mg/mL, and 0.039 mg/mL, respectively. On the other hand, methanol extract of S. chloranthum displayed the strongest ?-glucosidase inhibitory activity in sucrose as a substrate, similar to the IC50 value of the quercetin as a positive control. Furthermore, the antioxidant test showed that all medicinal plant extracts from East Kalimantan are good sources of natural antioxidants indicated by their IC50 values. The results of this study support the scientific background of the uses of medicinal plant extracts from East Kalimantan as folk medicine.
Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia RICO RAMADHAN; NISA’UR ROSYIDAH; YAZDANIYAR FAJRI HALIMI FIRDAUS; IRMAYANTI TRI KURNIA; DINDA AYU LESTARI; KIETTIPUM PHONTREE; PREECHA PHUWAPRAISIRISAN; LUKMAN RIYADI; ARRIZAL RAHMAN; NURLITA ABDULGANI; SILVI ARUM MARETNA; KAYLA NAULIA FADHILA
Biodiversitas Journal of Biological Diversity Vol. 24 No. 9 (2023)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d240919

Abstract

Abstract. Ramadhan R, Rosyidah N, Firdaus YFH, Kurnia IT, Lestari DA, Phontree K, Phuwapraisirisan P, Riyadi L, Rahman A, Abdulgani N, Maretna SA, Fadhila KN. 2023. Phytochemical analysis in conjunction with in vitro a-glucosidase inhibitory and antioxidant activities of three Diospyros species from East Kalimantan, Indonesia. Biodiversitas 24: 4783-4790. Locals who live in forested areas have long relied on Non-Timber Forest Products (NTFPs) for their traditional ceremonies, food, and medicine. As non-timber forest products, medicinal plants are of interest since they are used by locals in East Kalimantan regions, Indonesia, for local traditional medicine. In the search for new potential antidiabetics and antioxidants created from natural resources, the authors concentrated on medicinal plants traditionally used in East Kalimantan and ethnopharmacological data. The purpose of this study is to evaluate the dual roles of non-timber forest products, such as three Diospyros L. species, in a-glucosidase inhibition, antioxidant (free radical scavenging activity against DPPH and ABTS), and CUPRAC in-vitro activities. This study showed that the strongest a-glucosidase inhibitory activity was found in ethyl acetate and ethanol residue extracts of Diospyros celebica Bakh., with IC50 values of 4.5804±0.14 ug/mL and 3.8236±0.19 ug/mL respectively, which were more potent than quercetin as a positive standard. Additionally, the antioxidant test revealed that leaf extracts of three Diospyros species from East Kalimantan are excellent sources of natural antioxidants, as demonstrated by the SC50 values. The findings of this study support and validate the use of leaf extracts of three Diospyros species in traditional East Kalimantan medicine.
GC-MS analysis of three Diospyros species and evaluation of its in vitro rat intestinal a-glucosidase and FRAP activity NOVA ALFIAN HARIYANTO; RICO RAMADHAN; YANUARDI RAHARJO; YAZDANIYAR FAJRI HALIMI FIRDAUS; IRMAYANTI TRI KURNIA; DINDA AYU LESTARI; SUHARTINI SUWANDARI; NUR FARIHA MAHMUDA; JOURDHAM NATHANAEL; KIETTIPUM PHONTREE; PREECHA PHUWAPRAISIRISAN; LUKMAN RIYADI; ARRIZAL RAHMAN; NURLITA ABDULGANI
Biodiversitas Journal of Biological Diversity Vol. 25 No. 6 (2024)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d250613

Abstract

Abstract. Hariyanto NA, Ramadhan R, Raharjo Y, Firdaus YFH, Kurnia IT, Lestari DA, Suwandari S, Mahmuda NF, Nathanael J, Phontree K, Phuwapraisirisan P, Riyadi L, Rahman A, Abdulgani N. 2024. GC-MS analysis of three Diospyros species and evaluation of its in vitro rat intestinal a-glucosidase and FRAP activity. Biodiversitas 25: 2442-2453. The vast diversity of natural products has long been recognized as a potentially valuable source of bioactive compounds derived from nature. The Diospyros species, belonging to the Ebenaceae family, thrive in tropical forest regions and have been traditionally used for treating various disorders such as ischemic stroke, hypertension, and infectious diseases. This research aims to assess the phytochemical constituents, rat intestinal a-glucosidase, and Ferric-Reducing Antioxidant Power (FRAP) of non-polar (n-hexane) and semi-polar (dichloromethane) extracts from three Diospyros species, i.e., Diospyros buxifolia (Blume) Hiern; Diospyros celebica Bakh.; Diospyros confertiflora (Hiern) Bakh). Gas Chromatography-Mass Spectrometry (GC-MS) analysis identified numerous bioactive secondary metabolites in the extracts. The study revealed that the semi-polar extracts of D. buxifolia exhibited potent rat intestinal a-glucosidase inhibitory activities, with an IC50 value of 33.31±3.23 ug/mL. The IC50 of acarbose as a positive control was 6.31±0.31 ug/mL. The FRAP test demonstrated that the non-polar and semi-polar leaf extracts of the three Diospyros species from East Kalimantan are potential sources of natural antioxidants, with the IC50 in the range of 6.48±0.38 umol Fe/g - 11.35±0.16 umol Fe/g. The results of this study confirm the therapeutic properties of leaf extracts derived from 3 Diospyros species, which align with their traditional medicinal use.
Co-Authors ARRIZAL RAHMAN ARRIZAL RAHMAN DINDA AYU LESTARI DINDA AYU LESTARI IRMAYANTI TRI KURNIA IRMAYANTI TRI KURNIA JOURDHAM NATHANAEL KAYLA NAULIA FADHILA LUKMAN RIYADI LUKMAN RIYADI MUHAMMAD ZAINUL MUTTAQIN NISA’UR ROSYIDAH NOVA ALFIAN HARIYANTO NUR FARIHA MAHMUDA NURLITA ABDULGANI NURLITA ABDULGANI NURLITA ABDULGANI PREECHA PHUWAPRAISIRISAN PREECHA PHUWAPRAISIRISAN PREECHA PHUWAPRAISIRISAN RAMADHAN TOSEPU RICO RAMADHAN RICO RAMADHAN RICO RAMADHAN RUDIANTO AMIRTA SAPARWADI SAPARWADI SILVI ARUM MARETNA SUHARTINI SUWANDARI YANUARDI RAHARJO YAZDANIYAR FAJRI HALIMI FIRDAUS YAZDANIYAR FAJRI HALIMI FIRDAUS YAZDANIYAR FAJRI HALIMI FIRDAUS