The use of generic drugs in the community remains suboptimal despite their equivalent efficacy to branded drugs and more affordable prices. One of the factors influencing this condition is the lack of public knowledge regarding generic drugs. This study aimed to determine the difference in the level of public knowledge before and after receiving education about the use of generic drugs in Village X, Bekasi City. This study employed a quantitative method with a pre-experimental one-group pretest-posttest design. The sample consisted of 73 respondents selected using a purposive sampling technique. Data were collected using a closed-ended questionnaire with a Guttman scale that had been tested for validity and reliability. Education was provided through counseling using leaflet media. Data were analyzed using univariate. analysis and the Wilcoxon Signed Rank Test with a significance level of α = 0.05. The results showed that before the educational intervention, 15 respondents (20.55%) had a good level of knowledge, 33 respondents (45.20%) had a moderate level, and 25 respondents (34.25%) had a poor level of knowledge. After the educational intervention, all 73 respondents (100%) had a good level of knowledge. The Wilcoxon Signed Rank Test showed a significance value of p = 0.000 (p < 0.05), indicating a significant difference in knowledge levels before and after the educational intervention. It can be concluded that there was a difference in the level of public knowledge regarding the use of generic drugs after the educational intervention. Continuous education is needed to improve public understanding and promote rational drug use.