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All Journal Jurnal Riset Kefarmasian Indonesia Indonesian Journal of Health Science
Devi Maulina
Institut Kesehatan Hermina
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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In vitro antibacterial activity of Myrica javanica leaf extract against Staphylococcus aureus and Propionibacterium acnes. Varda Arianti; Yeni Marsela; Devi Maulina; Gaine Marvelous; Pra Panca Bayu Chandra
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.926

Abstract

Based on the Myrica genus, Myrica esculenta contains secondary  metabolites such as flavonoids, steroids, tannins, alkaloids, and saponins, that have the potential to act as antibacterial agents. This study aims to evaluate the antibacterial effectiveness of Myrica javanica extract against Staphylococcus aureus and Propionibacterium acnes in vitro. Extraction was performed using the maceration method with 96% ethanol, followed by antibacterial activity testing using the disk diffusion method at five extract concentrations (20%, 40%, 60%, 80%, 100%) with positive control (Clindamycin) and negative control  (DMSO). The results showed an increase in the maximum inhibition zone against the bacteria Staphylococcus aureus and Propionibacterium acnes measuring 14,04 ± 0,50 mm and 12,3 ± 0,64 mm respectively at concentration of 100%. In conclusion, the  extract of Myrica javanica shows potential antibacterial activity against both test bacteria.
Phytochemical screening and standardization of ethanol extract of Guava Leaves (Psidium guajava L.) with specific and non-spesific parameters Sukma Dwyastati Biadi; Varda Arianti; Dimas Adrianto; Devi Maulina
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1837

Abstract

This study aims to conduct phytochemical screening and standardization of guava leaf ethanol extract (Psidium guajava L.) originating from Gunung Putri, Bogor Regency, West Java. The extract was derived by means of maceration procedure utilizing 96% ethanol as the extraction medium, and phytochemical analysis confirmed the presence of flavonoids, alkaloids, tannins, saponins, terpenoid/steroid compounds, as well as glycosides. Quality evaluation based on specific and non-specific parameters showed results that met the standards: drying loss of  (<10%), total ash content of (<8,4%), specific gravity of 0.99 g/mL, water content of 5.2% (<10%), and negative heavy metal contamination. These results indicate that guava leaves from the Gunung Putri area have a phytochemical profile and extract quality that are suitable for the development of standardized herbal preparation raw materials. Geographical aspects also contribute to the validity of the results and can be a reference for standardization based on plant growing areas.
Level of knowledge of the Menteng community RT 010 RW 009 Menteng Village regarding the use of mefenamic acid tablets as an NSAID analgesic Azrizah Rahmadani; Amalina Fakhriah; Varda Arianti; Devi Maulina
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1969

Abstract

Mefenamic acid, a meclofenamate derivative, is a type of NSAID that inhibits the formation of the cyclooxygenase enzyme. This cyclooxygenase enzyme converts arachidonic acid into prostaglandins. Therefore, if this drug is given as a pain reliever to children or adolescents during their growth period, it will disrupt the longitudinal growth process of their bones. This study aims to evaluate the level of public knowledge in RT 010 RW 009, Menteng Village, Central Jakarta, regarding the use of mefenamic acid tablets as an NSAID analgesic. The method used is descriptive with a quantitative approach and involved 64 respondents selected based on inclusion criteria. The results show that the average level of public knowledge is in the sufficient category (63,20%). Respondents are predominantly in the 17–25 year age group with a vocational high school education level. Only 35.90% of respondents have received direct education from health workers. This finding emphasizes the importance of more intensive educational interventions from health institutions so that the public uses drugs appropriately and wisely.
The effect of ethanol extract of Wuru Ketek Leaves (Myrica javanica Reinw. ex Bl.) on the relative weight of organs in Male White Mice (Mus musculus L.) with alloxan-induced diabetes. Anna Uswatun Hasanah Rochjana; Varda Arianti; Devi Maulina; Fani Aprilia
Indonesian Journal of Health Science Vol 6 No 2 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i2.2151

Abstract

Wuru Ketek (Myrica javanica Reinw. ex Bl.) plant is known to contain flavonoids and tannins that have the potential as antidiabetics. This study aims to evaluate the effect of ethanol extract of wuru ketek leaves (Myrica javanica Reinw. ex Bl.) on the relative weight of the liver, kidneys, and heart of alloxan-induced diabetic male mice. A total of 30 mice were divided into six groups: normal group, negative control, positive control (glibenclamide), and three treatment groups with doses of 100, 200, and 300 mg/kgBW for 12 days orally. The organs were weighed and analyzed statistically. The results showed no significant difference in relative organ weight (p>0.05) between the treatment group and the normal group. These findings indicate that the ethanol extract of wuru ketek leaves (Myrica javanica Reinw. Ex Bl.) does not show toxic effects on target organs in the short term. Further studies are needed to assess long-term safety and other biochemical parameters.
The effect of education on community knowledge of antibiotic use in x housing complex, Bekasi Regency Nurul Salsabilah; Anna Uswatun Hasanah Rochjana; Amalina Fakhriah; Devi Maulina
Indonesian Journal of Health Science Vol 6 No 4 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i4.2390

Abstract

Irrational antibiotic use remains a public health concern because it can contribute to antibiotic resistance. One factor associated with this problem is the low level of community knowledge regarding appropriate antibiotic use. This study aimed to determine the difference in community knowledge before and after education on antibiotic use in X Housing Complex, Bekasi Regency. This quantitative study employed a pre-experimental design using a one-group pretest-posttest approach. The sample consisted of 53 respondents selected through purposive sampling. Data were collected using questionnaires administered before and after health education delivered through oral counseling with leaflet media. Data were analyzed using the Wilcoxon test. The results showed that before the educational intervention, most respondents had a moderate level of knowledge (58.5%), whereas after the intervention, all respondents had a good level of knowledge (100%). The Wilcoxon test showed a significant difference in knowledge levels before and after the educational intervention (p < 0.05). In conclusion, there was a difference in community knowledge before and after the provision of education. Therefore, continuous health education is recommended to support the rational use of antibiotics.
The effect of education on the level of public knowledge regarding the use of generic drugs in village x Bekasi City Dwi Imelda Afriliani; Anna Uswatun Hasanah Rochjana; Sylvi Adiana; Devi Maulina
Indonesian Journal of Health Science Vol 6 No 4 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i4.2403

Abstract

The use of generic drugs in the community remains suboptimal despite their equivalent efficacy to branded drugs and more affordable prices. One of the factors influencing this condition is the lack of public knowledge regarding generic drugs. This study aimed to determine the difference in the level of public knowledge before and after receiving education about the use of generic drugs in Village X, Bekasi City. This study employed a quantitative method with a pre-experimental one-group pretest-posttest design. The sample consisted of 73 respondents selected using a purposive sampling technique. Data were collected using a closed-ended questionnaire with a Guttman scale that had been tested for validity and reliability. Education was provided through counseling using leaflet media. Data were analyzed using univariate. analysis and the Wilcoxon Signed Rank Test with a significance level of α = 0.05. The results showed that before the educational intervention, 15 respondents (20.55%) had a good level of knowledge, 33 respondents (45.20%) had a moderate level, and 25 respondents (34.25%) had a poor level of knowledge. After the educational intervention, all 73 respondents (100%) had a good level of knowledge. The Wilcoxon Signed Rank Test showed a significance value of p = 0.000 (p < 0.05), indicating a significant difference in knowledge levels before and after the educational intervention. It can be concluded that there was a difference in the level of public knowledge regarding the use of generic drugs after the educational intervention. Continuous education is needed to improve public understanding and promote rational drug use.
Co-Authors Amalina Fakhriah Anna Uswatun Hasanah Rochjana Anna Uswatun Hasanah Rochjana Azrizah Rahmadani Dimas Adrianto Dwi Imelda Afriliani Fani Aprilia Gaine Marvelous Nurul Salsabilah Pra Panca Bayu Chandra Sukma Dwyastati Biadi Sylvi Adiana Varda Arianti Yeni Marsela