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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Lalu Husnul Hidayat
Magister Ilmu Farmasi, Fakultas Farmasi, Universitas Gadjah Mada
Medicine & Pharmacology

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POTENSI AKTIVITAS ANTIOKSIDAN DAN PENETAPAN KADAR FENOLIK TOTAL EKSTRAK DAUN KRATOM (Mitragyna speciosa Korth.) MENGGUNAKAN VARIASI PELARUT Akhmad Riski; Nanang Fakhrudin; Agung Endro Nugroho; Rakhmadhan Niah; Lalu Husnul Hidayat
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2802

Abstract

Kratom (Mitragyna speciosa) is a medicinal plant native to Southeast Asia that contains a wide range of secondary metabolites. The characteristics of medicinal plant extracts are strongly influenced by the type of solvent used during the extraction process, particularly with respect to phenolic compounds that play a key role in antioxidant activity. This study aimed to evaluate the antioxidant activity and total phenolic content of Mitragyna speciosa leaf extracts obtained using solvents with different degrees of polarity. Kratom leaves were extracted with water using the decoction method, as well as with 70% and 90% ethanol using the maceration method. Total phenolic content was determined by Spectrophotometer UV–Vis employing the Folin–Ciocalteu reagent with gallic acid as the standard, while antioxidant activity was assessed based on IC₅₀ values using the DPPH assay. The results showed that the total phenolic content of the water, 70% ethanol, and 90% ethanol extracts was 81.27 ± 0.13, 93.85 ± 0.07, and 99.21 ± 0.07 mg GAE/g extract, respectively. Antioxidant activity analysis revealed IC₅₀ values of 64.71 µg/mL for the water extract (strong antioxidant), 35.52 µg/mL for the 70% ethanol extract (very strong antioxidant), and 35.12 µg/mL for the 90% ethanol extract (very strong antioxidant). Based on these findings, the 90% ethanol extract exhibited the highest total phenolic content and the most potent antioxidant activity, indicating its potential for development as a natural antioxidant source derived from kratom leaves.
OPTIMASI FASE GERAK PADA KLT DAN IDENTIFIKASI METABOLIT SEKUNDER Ipomoea pes-caprae Lalu Husnul Hidayat; Yosi Bayu Murti; Nunung Yuniarti; Akhmad Riski
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2995

Abstract

Ipomoea pes-caprae (L.) R.Br traditionally used to treat pain, skin infections, inflammation, and rheumatic disorders. In vitro studies also reported antioxidant, anti-inflammatory, and antimicrobial potential activities obtained from secondary metabolites such as flavonoids, tannins, terpenoids, steroids, saponins, and alkaloids contained in Ipomoea pes-caprae. The purpose of this study is to optimize the mobile phase and identify secondary metabolite compounds of Ipomoea pes-caprae. The analysis used thin layer chromatography (TLC) in identifying compounds responsible for providing antioxidant activity with a spray reagent in the form of DPPH. The results showed the ideal of mobile phase, namely Chloroform: Ethyl Acetate: Methanol: Formic Acid (2: 7: 0.5: 0.5). Ethanol extract of 96% leaves has antioxidant activity with a DPPH spray reaction than ethyl acetate and N-hexane extracts. The metabolite profiles in samples with various specific reagents include the group of polyphenols, alkaloids and flavonoid compounds. Based on the results of the descriptive analysis, it was shown that the most dominant group of flavonoid compounds from ethanol extract was 96% of Ipomoea pes-caprae leaves, so it had a strong correlation with antioxidant activity.
Co-Authors Agung Endro Nugroho Akhmad Riski Nanang Fakhrudin, Nanang Nunung Yuniarti Rakhmadhan Niah Yosi Bayu Murti