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Delta Iswara
a:1:{s:5:"en_US";s:26:"An Nimah General Hospital ";}
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Posterior Ischaemic Optic Neuropathy (Pion) Secondary To Distal Segment Stenosis Of The Left Ophthalmic Artery: A Rare Case Report Delta Iswara; Hasna Okta Asyrofi; Hernawan Hernawan
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.733

Abstract

Ischaemic optic neuropathy (ION) is a vision-threatening condition caused by impaired arterial blood supply to the optic nerve. Posterior ischaemic optic neuropathy (PION) is a rare subtype that often presents without funduscopic abnormalities in the acute phase, making diagnosis challenging. We report a case of a 50-year-old man who presented with sudden, painless monocular visual loss in the left eye, accompanied by hemisensory deficits. Ophthalmic examination revealed no optic disc abnormalities, while automated perimetry demonstrated an inferior arcuate visual field defect. Brain magnetic resonance imaging showed a right corona radiata infarction, and digital subtraction angiography confirmed stenosis of the distal branches of the left ophthalmic artery. These findings supported the diagnosis of PION secondary to ophthalmic artery stenosis, an uncommon etiology of ION. The patient had uncontrolled hypertension as a major vascular risk factor and was treated with antiplatelet therapy, resulting in clinical improvement of visual acuity. This case highlights the importance of comprehensive vascular evaluation in patients with suspected PION and emphasizes ophthalmic artery stenosis as a rare but significant cause of ischaemic optic neuropathy. Early recognition of the underlying vascular pathology may facilitate appropriate management and help prevent further ischemic complications.
Lung Immune Prognostic Index (Lipi) As Prognostic Markers For Advanced Non-Small-Cell Lung Cancer (Nsclc) Treated With Immunotherapy: A Systematic Review And Meta-Analysis Delta Iswara; Anggita Dian Karera; Dyah Ati Sayuka; Rachmad Aji Saksana
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.735

Abstract

The Lung Immune Prognostic Index (LIPI), based on the derived neutrophil-to-lymphocyte ratio (dNLR) and lactate dehydrogenase (LDH) levels, has been recognized as an important prognostic biomarker in lung cancer. However, its prognostic value in patients with non–small cell lung cancer (NSCLC) has not been extensively discussed. Objective: This systematic review and meta-analysis aimed to comprehensively evaluate the association between LIPI and survival outcomes in patients with advanced-stage NSCLC receiving immunotherapy. Systematic literature search was conducted across PubMed, ScienceDirect, Cochrane Library, SSRN, Epistemonikos, and Google Scholar databases up to January 10, 2025. Study quality was assessed using the Newcastle–Ottawa Scale (NOS). Data were extracted for qualitative and quantitative synthesis, including pooled analyses and subgroup analyses. Random-effects models were applied to pool hazard ratios (HRs) with 95% confidence intervals (CIs) to assess the association between LIPI and progression-free survival (PFS) and/or overall survival (OS) in patients with advanced NSCLC treated with immunotherapy. A total of 7,551 patients from 13 studies were included in the analysis. Pooled analysis demonstrated that patients with poor or intermediate LIPI scores, compared with those with good LIPI scores, had significantly shorter PFS (HR = 2.20, 95% CI: 1.83–2.63, P < 0.001; HR = 1.47, 95% CI: 1.31–1.65, P < 0.001) and worse OS (HR = 3.31, 95% CI: 2.70–4.06, P < 0.001; HR = 1.88, 95% CI: 1.58–2.23, P < 0.001). Subgroup analyses based on immunotherapy type (monotherapy versus combination therapy) yielded consistent results. This study demonstrates that poor and intermediate LIPI scores are significantly associated with worse prognosis in patients with advanced-stage NSCLC receiving immunotherapy. Therefore, LIPI may serve as a promising non-invasive prognostic biomarker for predicting survival outcomes in this patient population. Keywords: lung immune prognostic index, LIPI, non–small cell lung cancer, immunotherapy.
Moderate Hyperkalemia Presenting As Sinus Arrest With Junctional Escape Rhythm From A Hospital With Resources Limited Setting: A Case Report And Narrative Review Delta Iswara; Anggita Dian Karera; Satrya Yudha Dwi Putranto; Rois Hasyim
International Journal of Health Engineering and Technology Vol. 5 No. 2 (2026): Vol 5. No. 2 JULY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i2.1073

Abstract

Hyperkalemia is a potentially life-threatening electrolyte disturbance that can cause severe cardiac conduction abnormalities, even at moderate serum potassium levels, particularly in elderly patients with underlying cardiovascular disease. Management of acute hyperkalemia remains challenging, especially in resource-limited healthcare settings where advanced therapies such as urgent dialysis may not be readily available. We report a 77-year-old woman who presented with generalized weakness and recurrent syncope. Electrocardiography revealed sinus arrest with a junctional escape rhythm, and laboratory evaluation showed moderate hyperkalemia (6.84 mmol/L) accompanied by acute kidney injury, anemia, and mild metabolic acidosis. The patient had a history of anterior ST-elevation myocardial infarction and was receiving potassium-retaining medications. She was admitted to the intensive care unit and treated with protocol-based glucose–insulin therapy, intravenous calcium gluconate, adjunctive β-adrenergic agonists, and supportive care, without immediate access to dialysis. Serial ECGs demonstrated recovery of sinus rhythm, and serum potassium levels gradually normalized. This case illustrates that moderate hyperkalemia can precipitate severe bradyarrhythmias such as sinus arrest. Early recognition of ECG changes and prompt, protocol-driven management can result in favorable outcomes, even in resource-limited settings without immediate dialysis availability.
Co-Authors Anggita Dian Karera Dyah Ati Sayuka Hasna Okta Asyrofi Hernawan Hernawan Rachmad Aji Saksana Rois Hasyim Satrya Yudha Dwi Putranto