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Inotrope Use and the Risk of Intraventricular Hemorrhage in Preterm Neonates: A Systematic Review and Meta Analysis Anggita Dian Karera; Delta Iswara; Amanah Sekar Kinasih; Dyah Ati Sayuka; Din Alfina
International Journal of Health Engineering and Technology Vol. 4 No. 4 (2025): IJHET NOVEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

More than 40% of neonatal hypotension cases are managed with inotropes; however, recent evidence indicates that inotrope administration, rather than hypotension itself, is independently associated with an increased risk of intraventricular hemorrhage (IVH) after adjustment for confounding factors. This systematic review and meta-analysis aimed to evaluate the association between inotrope use and the occurrence of IVH among preterm neonates. The study followed PRISMA guidelines. A systematic literature search was conducted through PubMed, Scopus, ScienceDirect, and Google Scholar. The methodological quality of each study was assessed using the Newcastle-Ottawa Scale (NOS) for case-control and cohort designs. Relevant data were extracted for qualitative and quantitative synthesis. Meta-analysis was performed using a random-effects model based on adjusted odds ratios (aORs) reported in each study, and the results were presented as pooled aORs with 95% confidence intervals. Eight studies met the inclusion criteria. The meta-analysis showed that inotrope use was significantly associated with a higher risk of IVH in preterm neonates, including IVH of any grade (pooled OR 2.03, 95% CI 1.25-3.29) and severe IVH (pooled OR 2.00, 95% CI 1.33-3.02). Overall, inotrope use doubled the risk of IVH (pooled OR 2.00, 95% CI 1.48-2.70). These findings emphasize the need for cautious and strictly indicated inotrope administration along with standardized hemodynamic management.
Neonatal Dengue: A Case Series of Three Patients with a Wide Clinical Spectrum Anggita Dian Karera; Hana Amelia; Delta Iswara; Din Alfina
International Journal of Health Engineering and Technology Vol. 4 No. 4 (2025): IJHET NOVEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

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Abstract

Neonatal dengue is an uncommon but clinically important condition that can present with a wide range of symptoms. This report describes three neonatal dengue cases with distinct clinical manifestations and emphasizes the importance of early recognition. The objective of this case series is to outline the clinical features, laboratory findings, and treatment outcomes of the affected neonates. All three patients presented with fever accompanied by various symptoms, including seizures, jaundice, respiratory distress, and significant thrombocytopenia. Diagnostic evaluation consisted of serological testing, hematological assessment, and imaging studies when needed. The lowest platelet counts ranged from 10,000 to 14,000 per microliter, although none of the neonates experienced major bleeding or shock. All patients received supportive treatment, including fluid management, monitoring, and therapy tailored to presenting symptoms. Each neonate demonstrated gradual improvement and was discharged in stable condition following appropriate observation. These cases highlight that neonatal dengue may resemble sepsis and thus requires a high level of diagnostic vigilance, particularly in endemic areas or when maternal dengue is suspected. Early serological testing in both mother and infant is valuable for timely diagnosis. Supportive care and close monitoring contribute significantly to preventing complications and achieving favorable outcomes.
Complete Atrioventricular (AV) Block In 15-Year-Old Girl: A Diagnostic And Therapeutic Challenge In Resource-Limited Setting Delta Iswara, Delta Iswara; Mahardhika Rafif Pratama; Anggita Dian Karera; Yislam Jaidi; Aldila Vidya Ditha Arianti
Jurnal Kesehatan Metro Sai Wawai Vol. 18 No. 2 (2025): Jurnal Kesehatan Metro Sai Wawai
Publisher : Poltekkes Kemenkes Tanjung Karang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jkmsw.v18i2.5332

Abstract

Complete atrioventricular (AV) block is a rare and life-threatening condition in children, characterized by complete electrical dissociation between the atria and ventricles. Its diagnosis and management can be particularly challenging in resource-limited settings. A 15-year-old girl presented with chest discomfort, dyspnea, nausea, and vomiting. On examination, she was hemodynamically unstable with bradycardia (heart rate 48–58 bpm). Electrocardiography revealed a complete AV block with junctional escape rhythm. Further evaluation, including echocardiography, showed no structural heart defects and preserved ventricular function. Management included fluid resuscitation and dopamine infusion, titrated up to 20 mcg/kg/min. During titration, the patient developed ventricular tachycardia–induced bradycardia that resolved spontaneously after dose reduction. Following stabilization, the patient was referred to a higher-level facility for permanent pacemaker implantation and further investigation of the underlying etiology. This case highlights the importance of early recognition and timely intervention in pediatric complete AV block. In settings with limited resources, dopamine infusion may serve as a temporary bridging therapy when transfer is delayed, but careful monitoring is essential due to the risk of arrhythmias. Prompt diagnosis, appropriate stabilization, and early referral are crucial to reducing morbidity and preventing fatal outcomes.