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All Journal Jurnal Indah Sains dan Klinis
Nerly Juli Pranita Simanjuntak
Fakultas Kedokteran, Gigi dan Ilmu Kesehatan Universitas Prima Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing

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Potensi Antihiperglikemia Kombinasi Ekstrak Daun Salam dan Ikan Gabus Razoki Razoki; Nerly Juli Pranita Simanjuntak
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.04

Abstract

Background: Flavonoids, as secondary metabolites found in bay leaves, exhibit antioxidant properties that help prevent damage to pancreatic β cells by neutralizing free radicals responsible for cell injury. Protein from snakehead fish plays a role in regulating blood sugar levels by inhibiting the α-glucosidase enzyme. Objective: This study aimed to assess the potential of combining the two extracts to lower blood sugar levels in mice. Method: Six groups were used in the study, each receiving a 250 mg/kg BW dose and 40% glucose inducer: Aquades (A), ethanol extract of bay leaves (EEDS), snakehead fish extract (EIG), and combinations of ethanol extracts of bay leaves and snakehead fish (EEDS-IG) in ratios of 1:1, 2:1, and 3:1 (w/w). Results: The study revealed that EEDS and EIG reduced blood sugar levels by 12.14%, 66.9%, 55.0%, 69.3%, 69.7%, and 69.3% at the 120th minute, respectively, for each group. Conclusion: The combination of EEDS and EIG has the potential to reduce blood sugar levels, particularly at a 2:1 ratio
Co-Authors Razoki Razoki