Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal JURNAL FARMASIMED (JFM) Jurnal Pengmas Kestra (JPK)
Desy Lustiyani Rajagukguk
Institut Kesehatan Medistra Lubuk Pakam
Health Professions Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Socialization of Gastritis and Gastroenteritis Prevention through the Introduction of Helicobacter pylori and Escherichia coli to the Community Rahmawati; Yudisthira Yudisthira; Arif Sujatmiko; Sofiani Sari; Siti Hardianti; Desy Lustiyani Rajagukguk
JURNAL PENGMAS KESTRA (JPK) Vol. 6 No. 1 (2026): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/21a1xd72

Abstract

Gastritis and gastroenteritis are gastrointestinal infectious diseases that remain significant public health concerns, particularly in areas where Clean and Healthy Living Behavior (PHBS), personal hygiene, and environmental sanitation have not been optimally implemented. Gastritis is commonly associated with Helicobacter pylori infection, whereas gastroenteritis is often caused by pathogenic bacteria, including Escherichia coli. Limited public knowledge regarding the causes, modes of transmission, risk factors, and preventive measures for these diseases may increase the risk of infection. Therefore, this Community Service Program aimed to improve public knowledge and awareness of gastritis and gastroenteritis prevention through the introduction of Helicobacter pylori and Escherichia coli. The activity involved 30 participants and was conducted through health education sessions, interactive discussions, question-and-answer sessions, and the use of educational media, including posters and leaflets. The effectiveness of the program was evaluated using pre-test and post-test assessments to measure participants' knowledge before and after the educational intervention. The results showed that the mean knowledge score increased from 61.3 (moderate category) in the pre-test to 91.7 (very good category) in the post-test. These findings indicate that the educational intervention was effective in improving participants' understanding of the causes, transmission routes, symptoms, risk factors, and preventive measures for gastritis and gastroenteritis through the implementation of Clean and Healthy Living Behavior (PHBS), proper hygiene, environmental sanitation, and food safety practices. This community service activity is expected to enhance public health literacy and encourage sustainable healthy behaviors to prevent gastrointestinal infectious diseases.
Immunostimulatory Activity of Opu-Opu (Crinum asiaticum L.) Leaf Extract on Lymphocyte Proliferation Romauli Anna Marbun; Ratih Anggraeni; Desy Lustiyani Rajagukguk; Nisa Elhasanah
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.4076

Abstract

Background: Opu-opu leaves (Crinum asiaticum L.) are medicinal plant materials containing various secondary metabolites with potential immunomodulatory activities. Immunostimulatory activity can be evaluated by examining lymphocyte responses, which play an essential role in adaptive immunity. Objective: This study aimed to evaluate the activity of ethanolic extract of opu-opu leaves (Crinum asiaticum L.) on lymphocyte proliferation as a potential immunostimulatory agent. Methods: This experimental study involved extracting opu-opu leaves by maceration using 96% ethanol. Phytochemical screening was performed using thin-layer chromatography (TLC), while lymphocyte proliferation-related activity was evaluated using the MTT assay. The extract was tested at concentrations of 3.125, 6.25, 12.5, and 25 µg/mL, with Imboost® serving as the positive control. Cellular activity was assessed based on absorbance measurements and the Effective Concentration (EC50) value. Results: Extraction of 500 g of dried plant material yielded 12.25 g of extract, corresponding to a yield of 2.45%. The reported EC50 values were 4.446 µg/mL for the opu-opu leaf extract and 4.282 µg/mL for Imboost®. Extract absorbance increased with concentration, reaching 0.234 ± 0.05, 0.261 ± 0.05, 0.341 ± 0.04, and 0.432 ± 0.01, respectively. The highest absorbance was observed at 25 µg/mL, compared with 0.234 ± 0.01 in the negative control. Conclusion: The ethanolic extract of opu-opu leaves demonstrated potential immunostimulatory activity, as indicated by increased lymphocyte metabolic activity measured using the MTT assay. However, direct confirmation of lymphocyte proliferation and further safety evaluation are required to support its development as an immunostimulatory agent.
Co-Authors Arif Sujatmiko Nisa Elhasanah Rahmawati Ratih Anggraeni Romauli Anna Marbun Siti Hardianti Sofiani Sari Yudisthira Yudisthira