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All Journal Majalah Kedokteran Bandung Jurnal Ners Jurnal MedScientiae
Sihombing, Martina Rentauli
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Aspek Klinis dan Pemeriksaan Laboratorium Sindrom Hiperimunoglobulin-M Sihombing, Martina Rentauli
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3324

Abstract

Hyperimmunoglobulin-M Syndrome (HIGM) is a set of symptomps  due to primary immunodeficiency characterized by low levels of immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin E (IgE), and normal or increased levels of immunoglobulin M (IgM) or recurrent infections. HIGM syndrome was initially thought to be caused by genetic defects related to the X chromosome only, but along with advances in molecular technology in detecting genetic abnormalities, other autosomal-type defects were found. Genetic defects in HIGM Syndrome cause disruption of the maturation process of humoral immunity, especially diversity through CSR, and increased affinity through SHM. Clinical manifestation of HIGM patients varies greatly and depends on the defect in the CD40L or CD40 signal pathway. Current therapy given for HIGM patients aim to resolve those clinical manifestation and fix the production of high-affinity antibody. Life expectancy of patients without a bone marrow transplant is estimated to be less than 30 years.
Uji Fungsi Khusus Automated Hematology Analyzer Sysmex Xn-2000 Edward, Harny; Luciana, Linny; Yemmy, Yemmy; Sari, Dominica Pita; Sihombing, Martina Rentauli; Sinsanta , Sinsanta
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.43590

Abstract

Hematologi merupakan salah satu parameter diagnostik laboratorium yang berperan penting dalam evaluasi kesehatan dan deteksi berbagai kondisi patologis. Setiap alat hematologi memiliki metode kerja, prinsip pengukuran, dan tingkat akurasi yang berbeda, sehingga perlu dilakukan uji fungsi untuk memastikan kesesuaian dan konsistensi hasil antara alat yang berbeda. Penelitian ini bertujuan untuk membandingkan performa dua alat hematologi analyzer dalam mengukur parameter darah utama, seperti jumlah hemoglobin, leukosit, dan trombosit. Uji banding dilakukan untuk menilai akurasi, presisi, dan kesesuaian hasil antara kedua alat, sehingga dapat memastikan hasil laboratorium yang valid. Metode penelitian menggunakan jumlah sampel minimal untuk uji banding sebesar 20 subjek meliputi 10 sampel normal dan 10 sampel abnormal. Hasil yang diperoleh dibandingkan menggunakan uji statistik korelasi Pearson untuk menilai kesesuaian dan hubungan kedua alat. Selain itu dilakukan uji performa alat berupa uji within run dan between day menggunakan tiga level kontrol kemudian dianalisis CV dan SD. Kedua alat Hematology analyzer mempunyai CV yang baik dan tidak melampaui batas yang ditentukan CLSI dan literatur masing-masing parameter yaitu hemoglobin <1%, leukosit <3%, trombosit <4%. Uji komparasi menunjukkan korelasi kuat antara kedua alat dalam menguji sampel untuk ketiga parameter tersebut dengan r > 0,99 dan p<0,05. Penelitian ini menunjukkan bahwa Sysmex XN-2000 dan XN-1000 mempunyai presisi dan akurasi yang baik. Dengan hasil korelasi yang baik maka kedua alat ini dapat saling menggantikan.
Gambaran Kejadian Anemia pada Pasien Penyakit Ginjal Kronik (PGK) di RSUD Karawang Tahun 2024 Cahya, Karwili Dwi; Sihombing, Martina Rentauli; Pita Sari, Dominica; Timan, Ina Susianti
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3645

Abstract

Chronic Kidney Disease (CKD) is a progressive and irreversible condition characterized by a decline in the glomerular filtration rate (GFR). One of the most common complications in CKD patients is anemia. Anemia is a condition in which the number of red blood cells or hemoglobin levels in the blood are below normal. The primary cause of anemia in CKD patients is the decreased production of erythropoietin (EPO), a hormone that stimulates red blood cell formation in the bone marrow. This study aims to describe the condition of anemia in CKD patients at RSUD Karawang from January to December 2024. This is a descriptive study with a retrospective approach and a cross-sectional design. Medical record data of patients were used as the research instrument. A total of 106 samples were taken. The results showed that 57 samples were male (53.8%), and the largest age group was 41–59 years (40.6%). Out of 106 samples, 85 samples (80.2%) had anemia, with 41 samples (38.7%) presenting severe anemia. Hypertension was the most common comorbidity in CKD patients, found in 53.8% of cases.
HbA1c Level in Type 2 Diabetes Mellitus Patients With and Without Obesity in An Indonesian Regional Hospital Tinangon, Fritsal; Luciana, Linny; Sihombing, Martina Rentauli; Edward, Harny
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3990

Abstract

Diabetes Mellitus (DM) is a disease characterized by hyperglycemia due to insulin deficiency or impaired insulin function. The International Diabetes Federation (IDF) estimated that approximately 463 million people aged 20 to 79 years old were affected by DM worldwide in 2019. Indonesia is the third highest with a prevalence of 11.3%. More than 90% of diabetic patients are obese which reduced insulin sensitivity. This study aimed to determine the difference in HbA1c levels between obese and non-obese patients with Type 2 Diabetes Mellitus (T2DM) at Tarakan Regional Hospital, Indonesia. Data from medical records of T2DM patients from January to December 2023 were collected based on inclusion and exclusion criteria using consecutive sampling method, resulting in 128 samples. The results of the study, as determined using the Mann Whitney test, indicated a significant difference in the HbA1c levels between T2DM patients with and without obesity (p=0.031), with non-obese T2DM patients tend to have better HbA1c control compared to their obese counterparts. Thus, it can be inferred that obesity affects the blood glucose control in diabetic patients. However, this result needs to be further researched as there are a few limitations inherent to this study, particularly the partial availability of certain medical record information, such as duration of diagnosis and medication adherence.
Co-Authors Cahya, Karwili Dwi Edward, Harny Ina Susianti Timan Linny Luciana Luciana, Linny Pita Sari, Dominica Sari, Dominica Pita Sinsanta , Sinsanta Tinangon, Fritsal Yemmy, Yemmy