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All Journal Majalah Kedokteran Bandung Indonesian Research Journal on Education Jurnal MedScientiae
Sihombing, Martina Rentauli
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Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal MedScientiae

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Aspek Klinis dan Pemeriksaan Laboratorium Sindrom Hiperimunoglobulin-M Sihombing, Martina Rentauli
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3324

Abstract

Hyperimmunoglobulin-M Syndrome (HIGM) is a set of symptomps  due to primary immunodeficiency characterized by low levels of immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin E (IgE), and normal or increased levels of immunoglobulin M (IgM) or recurrent infections. HIGM syndrome was initially thought to be caused by genetic defects related to the X chromosome only, but along with advances in molecular technology in detecting genetic abnormalities, other autosomal-type defects were found. Genetic defects in HIGM Syndrome cause disruption of the maturation process of humoral immunity, especially diversity through CSR, and increased affinity through SHM. Clinical manifestation of HIGM patients varies greatly and depends on the defect in the CD40L or CD40 signal pathway. Current therapy given for HIGM patients aim to resolve those clinical manifestation and fix the production of high-affinity antibody. Life expectancy of patients without a bone marrow transplant is estimated to be less than 30 years.
Gambaran Kejadian Anemia pada Pasien Penyakit Ginjal Kronik (PGK) di RSUD Karawang Tahun 2024 Cahya, Karwili Dwi; Sihombing, Martina Rentauli; Pita Sari, Dominica; Timan, Ina Susianti
Jurnal MedScientiae Vol. 4 No. 1 (2025): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i1.3645

Abstract

Chronic Kidney Disease (CKD) is a progressive and irreversible condition characterized by a decline in the glomerular filtration rate (GFR). One of the most common complications in CKD patients is anemia. Anemia is a condition in which the number of red blood cells or hemoglobin levels in the blood are below normal. The primary cause of anemia in CKD patients is the decreased production of erythropoietin (EPO), a hormone that stimulates red blood cell formation in the bone marrow. This study aims to describe the condition of anemia in CKD patients at RSUD Karawang from January to December 2024. This is a descriptive study with a retrospective approach and a cross-sectional design. Medical record data of patients were used as the research instrument. A total of 106 samples were taken. The results showed that 57 samples were male (53.8%), and the largest age group was 41–59 years (40.6%). Out of 106 samples, 85 samples (80.2%) had anemia, with 41 samples (38.7%) presenting severe anemia. Hypertension was the most common comorbidity in CKD patients, found in 53.8% of cases.
Co-Authors Cahya, Karwili Dwi Edward, Harny Ina Susianti Timan Irvinto, Lie Linny Luciana Luciana, Linny Pita Sari, Dominica Sari, Dominica Pita Sinsanta Sinsanta Tinangon, Fritsal