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All Journal Jurnal Multidisiplin West Science
Muhammad Khalid Mirza
Universitas Malikussaleh
Economics, Econometrics & Finance

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The Effects of Moringa oleifera on Blood IL-6 Levels: A Scoping Review Muhammad Husni Fansury Nasution; Sarah Rahmayani Siregar; Maulana Ikhsan; Rivhan Fauzan; Dwi Martha Nur Aditya; Putri Eka Sari; Anis En Nabiilah; Muhammad Khalid Mirza; Andi Saputra
Jurnal Multidisiplin West Science Vol 5 No 08 (2026): Jurnal Multidisiplin West Science
Publisher : Westscience Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/jmws.v5i08.3705

Abstract

Interleukin-6 (IL-6) is widely used as an inflammatory biomarker and has also become a therapeutic target in several inflammatory and malignant diseases. Moringa oleifera (MO) has been reported to possess anti-inflammatory activity, yet evidence regarding its effect on blood IL-6 levels remains limited. This scoping review analyzed available evidence on the effect of MO on blood IL-6 levels. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). A PubMed search was conducted using the keywords ((Moringa oleifera) AND (Interleukin-6 OR IL-6)) AND (blood), covering publications from January 2006 to January 2026. Nine studies met the inclusion criteria. All studies used animal experimental models, measured IL-6 in serum using ELISA, and applied randomized placebo-controlled designs. Most studies reported a significant reduction in blood IL-6 levels after MO intervention. The preparations included aqueous extracts, ethanol extracts, polyphenol extracts, n-butanol fractions, seed powder, and beta-sitosterol isolated from n-butanol seed extract. Overall, MO may have prophylactic potential for chronic inflammatory conditions characterized by elevated blood IL-6 levels; however, standardized preparations and human studies are still needed.
Co-Authors Andi Saputra Anis En Nabiilah Dwi Martha Nur Aditya Maulana Ikhsan Muhammad Husni Fansury Nasution Putri Eka Sari Rivhan Fauzan Sarah Rahmayani Siregar