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All Journal Jurnal Kedokteran Jurnal Pengabdian Magister Pendidikan IPA Sasambo Journal of Pharmacy Jurnal Sains dan Kesehatan
Wahida Hajrin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology

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Formulasi Lotion Esktrak Etanolik Herba Ashitaba (Angelica Keiskei) sebagai Penangkal Radikal Bebas Wahida Hajrin; Yohanes Juliantoni
Jurnal Kedokteran Vol 8 No 2 (2019)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v8i2.335

Abstract

Senyawa radikal dapat merusak serabut kalogen kulit dan matrik dermis sehingga kulit menjadi kering, keriput, bahkan dapat menjadi penuaan dini. Upaya pencegahan yang dapat dilakukan yaitu dengan penggunaan bahan yang memiliki aktivitas antioksidan. Salah satu tanaman yang memiliki aktivitas antioksidan adalah ashitaba. Metode yang digunakan pada penelitian ini adalah variasi pengeringan ashitaba untuk melihat pengaruhnya terhadap aktivitas penangkapan radikal DPPH dan kadar fenolik total ekstrak etanoliknya. Sampel dengan metode pengeringan yang lebih baik, digunakan untuk membuat sediaan lotion. Hasil penelitian menunjukkan sampel yang dikeringkan dengan oven memiliki rendemen lebih tinggi dari pada dengan sinar matahari. Aktivitas penangkapan radikal DPPH sampel oven dengan IC50 sebesar 350,24 µg/mL lebih baik dari pada sampel matahari yaitu sebesar 3979,46 µg/mL (p0.05). Hasil uji kadar fenolik total sampel oven sebesar 2,9817±0,0935 gEAG/100g lebih tinggi dari pada sampel matahari sebesar 1,7168±0,0142 gEAG/100g sampel. Sampel yang dikeringkan dengan oven kemudian diformulasi dalam bentuk sediaan lotion. Uji acceptabilitas menunjukkan ekstrak etanolik herba ashitaba cocok dibuat sediaan lotion. Ekstrak etanolik herba Ashitaba dapat dibuat sediaan lotion namun perlu dilakukan optimasi formula dan uji stabilitas untuk memperoleh sediaan lotion yang baik.
Formulasi dan Evaluasi Sifat Fisik Lotion Ekstrak Etanol Daun Kemuning (Murraya paniculata (L) Jack) dan Daun Lidah Buaya (Aloe vera Linn) Windah Anugrah Subaidah; Yohanes Juliantoni; Wahida Hajrin
Sasambo Journal of Pharmacy Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.65 KB) | DOI: 10.29303/sjp.v1i1.6

Abstract

The ultraviolet radiation and skin water loss could damage the skin. Kemuning leaves (Murraya paniculata (L) Jack) as a source of anti-oxidants and Aloe vera leaves (Aloe vera Linn) can prevent this action. This study aims to formulate and evaluate lotion containing the Kemuning leaves and Aloe vera extract. The extract of Kemuning leaves was obtained by sonication using 70% ethanol solvent. Aloe vera juice was obtained by smoothing the aloe vera gel then filtered using clean gauze.  The kemuning leaves extract and aloe vera extract had formulated into lotion preparation. The physical properties of the lotion (homogeneity, type of emulsion, pH, spreadability, and adhesion) were determined. The organoleptic test showed that the color of the lotion was pale yellow with a smooth texture and had extract scent. The lotion was showed good homogeneity, spreadability 7.31 cm, pH 7, type oil in water and adhesion 45 seconds. The physical properties parameters of lotion preparations showed that the lotion preparations had fulfilled the requirements of good preparations.
Formulasi Sediaan Gel Sari Buah Duwet (Syzygium cumini) dengan Basis Karbopol 940 Sebagai Gelling Agent Yohanes Juliantoni; Wahida Hajrin; Windah Anugrah Subaidah
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.863 KB) | DOI: 10.29303/sjp.v1i2.14

Abstract

Duwet fruit (Syzygium cumini) is a local Indonesian fruit that has many benefits. Duwet juice contains antioxidants that have DPPH free radical activity. But the use of duwet fruit is not practical for modern society. This research was conducted to formulate duwet juice into a gel-based carbopol 940 with the physical quality test of the gel. Duwet fruit extraction was tested for phytochemical screening qualitatively. The gel is made in 5 formulas namely I (100% aquadest: 0% ethanol 70%); II (75% aquadest: 25% ethanol 70%); III (50% aquadest: 50% ethanol 70%); IV (25% aquadest: 75% ethanol 70%); and V (0% aquadest: 100% ethanol 70%). The results showed that Duwet juice contained of flavonoid, polyphenols, and anthocyanins based on phytochemical screening tests. The formula of gel I, II, and III has fulfilled the pH requirements of 4.5-6.5, homogeneity, and spread capacity of 5-7 cm. Increasing the concentration of 70% ethanol in the gel formula will increase the pH value and spread capacity.
PHYSICAL STABILITY STUDY OF OINTMENT FROM LEAF EXTRACT OF TEKELAN (Chromolaena odorata L.) ON VARIOUS TYPES OF BASES Susanti; Wahida Hajrin; Nisa Isneni Hanifa
Unram Medical Journal Vol 10 No 4 (2021): Jurnal Kedokteran Volume 10 nomor 4 (Desember) 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i4.592

Abstract

Tekelan (C. odorata) contains phenolic compounds that play an important role in wound healing. The potential of C. odorata leaves as a wound healer needs to be developed through the formulation of ointment to facilitate its use. The selection of ointment base will affect the effectiveness. The aim of this study was to determine the physical stability of ointment from C. odorata leaf extract on varios types of bases. The ointment of C. odorata leaf extract with four types of bases, i.e hydrocarbon base (F1), adsorption base (F2), washable base (F3), and water soluble base (F4) were tested for stability using mechanichal method and freeze-thaw cycle. Mechanichal stability test was carried out by centrifuging the samples at a speed 3750 rpm for 30 menutes, while the freeze-thaw cycle test was carried out for 12 days (6 cycles). The physical properties of ointment i.e organoleptics, homogeneity, pH, spreadability, and sticky power before and after the test were compared by ANOVA. The result of mechanichal test of ointment showed that there is no separation in all types of bases. Stability test by freeze-thaw cycle method indicated a change of homogeneity and organoleptic of F1 and F2. Spreadability of all formulas was not significantly different before and after the freeze-thaw cycle, while the stable sticky power only occurred at F4 (p-value=0.523). Formula F4 which is an ointment of C. odorata leaf extract with a water soluble base has the best stability among other bases.
Pelatihan Pembuatan Masker peel-off Lidah Buaya (Aloe vera) Untuk Mengatasi Efek Sunburn Windah Anugrah Subaidah; Wahida Hajrin; Yohanes Juliantoni
Jurnal Pengabdian Magister Pendidikan IPA Vol 3 No 2 (2020): .
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.801 KB) | DOI: 10.29303/jpmpi.v3i2.511

Abstract

Tingginya angka pengangguran di kota Mataram diantaranya kurangnya pendidikan dan keterampilan dari tenaga kerja. Lulusan SMA membutuhkan keterampilan untuk menciptakan lapangan pekerjaan dan mengurangi angka pengangguran. Salah satu peluang wirausaha adalah dengan membuat masker peel off lidah buaya (Aloe vera). Hal ini dilatar belakangi oleh intensitas matahari yang tinggi didaerah Indonesia yang cenderung menimbulkan efek negatif pada kulit terutama sunburn. Bahan baku lidah buaya yang mudah diperoleh dan mempunyai aktivitas sebagai antiinflamasi dari sunburn. Metode pelaksanaan pengabdian untuk memecahkan masalah mitra siswa SMAIT Anak Sholeh Mataram terdiri dari tiga tahapan yaitu persiapan kegiatan, pelaksanaan kegiatan, dan monitoring dan evaluasi. Hasil kegiatan pengabdiaan menunjukkan bahwa peserta memberikan tanggapan yakni peserta merasa pelatihan ini bermanfaat, proses pembuatan sediaan mudah dan pesesrta akan membuat masker lidah buaya. Tanggapan lainnya yakni penyajian materi menarik, materi yang disajikan mudah dipahami dan secara umum peserta puas terhadap kegiatan pengabdian masyarakat pembuatan masker lidah buaya ini
Formulasi dan Karakterisasi Fitosom Ekstrak Biji Buah Makasar (Brucea Javanica (L) Merr) dengan Metode Pembuatan Hidrasi Lapis Tipis: Formulation and Characterization of Phytosome Extract Makassar Fruit Seeds (Brucea Javanica (L) Merr) with the Method of Manufacturing Thin Layer Hydration Nur Amalina Sabdarrifa; Windah Anugrah Subaidah; Sucilawaty Ridwan; Wahida Hajrin
Jurnal Sains dan Kesehatan Vol. 7 No. 1 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i1.2392

Abstract

Brucea javanica seeds hold promise as a powerful antioxidant source, boasting a high phenol content (61.1927±0.1560 mg GAE/g sample) and an IC50 value of 64,703 ppm. However, the inherent polar and bulky nature of these phenols limits their absorption in the body, hindering their effectiveness. This research introduces phytosomes, a potential solution, derived from Brucea javanica seed extract. The phytosomes are prepared using sonication and thin-film hydration techniques, with optimized parameters for phospholipid concentration, processing speed, and rotary evaporator temperature. Different ratios of phospholipid to Brucea javanica extract (1:1, 1:2, 1:3, and 2:1) are evaluated to determine the optimal phytosome formulation. Encapsulation efficiency serves as the primary parameter for selection. Finally, the most promising phytosome is characterized for particle size, polydispersity index, vesicle morphology, and the complexity of the formed compounds using infrared spectroscopy. This study strives to develop an optimal phytosome formulation from Brucea javanica seeds with superior absorption, aiming to enhance the antioxidant's pharmacological effects and open new avenues in the healthcare field. Keywords:          Brucea javanica, antioxidants, phenols, phytosomes, hydration of thin films   Abstrak Biji Brucea javanica kaya fenol (61,1927±0,1560 mg GAE/g sampel) dengan nilai IC50 64,703 ppm. Sifat polar dan bermolekul besar fenol menghambat absorpsinya. Penelitian ini menghadirkan fitosom dari ekstrak biji Brucea javanica untuk meningkatkan absorpsi. Fitosom diolah dengan metode sonikasi dan hidrasi lapis tipis, dengan optimasi konsentrasi fosfolipid, kecepatan, dan suhu rotary evaporator. Berbagai perbandingan fosfolipid dan ekstrak Brucea javanica (1:1, 1:2, 1:3, dan 2:1) dievaluasi untuk menentukan formula fitosom terbaik. Efisiensi penjerapan menjadi parameter utama. Fitosom dengan formula terbaik dikarakterisasi untuk mengetahui ukuran partikel, indeks polidispersitas, morfologi vesikel, dan kompleksitasnya dengan spektroskopi inframerah. Penelitian ini diharapkan menghasilkan formulasi fitosom optimal dari biji Brucea javanica dengan daya serap tinggi, meningkatkan efek farmakologisnya, dan membuka peluang baru di bidang kesehatan. Kata Kunci:         Brucea javanica, antioksidan, fenol, fitosom, hidrasi lapis tipis
Co-Authors Nisa Isneni Hanifa Nur Amalina Sabdarrifa Sucilawaty Ridwan SUSANTI Windah Anugrah Subaidah Yohanes Juliantoni Yohanes Juliantoni