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All Journal Jurnal Biologi Tropis
Alfia Andriyani
Stikes Pemkab Jombang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Effect of Moringa Oleifera Leaf Nanoparticles on IL-10 in Vivo Model of Oral Cavity Malignancy Mariana Asmaningdiah; Alfia Andriyani
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11489

Abstract

Interleukin-10 (IL-10) which is secreted by Th 2 cells. Interleukin- 10 is an anti-inflammatory cytokine that plays an important role in the regulation of the host immune response by inhibiting the release of pro-inflammatory mediators. Moringa leaf nanoparticles (Moringa oleifera) are products that contain various bioactive mediators that can play a role in inflammation. The aim of this study was to determine the effect of administering Moringa leaf extract nanoparticles on IL-10 levels in oral cavity cells undergoing malignant transformation. Eighteen male Wistar rats (R. novergicus) were used as animal models that underwent benzo(a)pyrene induced malignant transformation in the oral cavity. Moringa leaf extract nanoparticles with concentrations of 0.250 mg/mL, and 0.500 mg/ were given to the treatment group for 14 days. The results of IL-10 levels were evaluated using the ELISA method. Data analysis using the Kruskall-Wallis test was carried out to analyze differences between groups. Aplication Moringa oleifera leaf nanoparticles with concentrations of 0.250 mg/mL, and 0.500 mg/mL were able to reduce levels of IL-10 in oral cells undergoing malignant transformation. The results of this study showed that the p-value = 0.726 (> 0.05) which means that there was no effect of the application of moringa leaf extract nanoparticles in a mouse model with malignant transformation of oral cells on reducing IL-10 levels.
Effect of Snakehead Fish Albumin Extract Supplementation on SGOT and SGPT Levels in Tuberculosis Patients Alfia Andriyani; Jusak Nugraha; Retno Indrawati; Theresia Budhy S; Nurul Hidayah; Mariana Asmaningdiah; Inas Hasna Azizah; Ahmad Hidayat
Jurnal Biologi Tropis Vol. 26 No. 2 (2026): April - Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i2.11851

Abstract

Long-term use of OAT in tuberculosis patients carries a high risk of triggering drug-induced liver damage characterized by a spike in serum transaminase enzyme levels SGOT and SGPT. This study aims to determine the effect of snakehead fish extract therapy on SGOT and SGPT levels in TB patients undergoing intensive phase treatment. This study is quasi-experimental study with a randomized controlled trial design post-test only control group design.  The research population was TB patients at the Sidotopo Community Health Center, Surabaya, who were selected using a random sampling technique purposive sampling until 20 respondents were obtained. Respondents were systematically divided into two groups, control group (OAT therapy) and treatment group (OAT therapy accompanied by supplementation of 500 mg albumin extract capsules). Comparative data analysis between groups was conducted using Independent Sample T-test. The results of the statistical analysis showed that the average SGOT level in intensive phase patients was 21.95 U/L and the average SGPT level was 19.65 U/L, where both valuesremained within normal clinical limits. The inter-group comparison hypothesis test produced a value p-value for SGOT levels of 0.907 and the value p-value for SGPT levels of 0.346. These data indicate no significant difference in the fluctuation of SGOT or SGPT levels between control and treatment groups. Supplementation with snakehead fish albumin extract did not show a significant difference in effect on SGOT and SGPT levels, but was proven to be able to maintain a stable and normal liver transaminase enzyme profile during intensive phase of OAT treatment.
Co-Authors Ahmad Hidayat Inas Hasna Azizah Jusak Nugraha Mariana Asmaningdiah Nurul Hidayah Retno Indrawati Theresia Budhy S