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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Jamu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Nanogel Formulation of Butterfly Pea Flower Extract (Clitoria ternatea L.) Against Propionibacterium acnes Bacteria Inhibitory Test Niluh Puspita Dewi; Radhika; Magfirah; Indah Kurnia Utami; Yasinta Rakanita; Nur Ramadhani; Nuraisya; Ni Ketut Marlina
Jurnal Penelitian Pendidikan IPA Vol 12 No 6 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i6.15211

Abstract

The chemical components of butterfly pea flowers (Clitoria ternatea L.) have a strong bacterial inhibition zone. The aim of this research is to make nanogels using the active ingredient ethanol extract of butterfly pea flowers and demonstrate the antibacterial activity of nanogels against Propionibacterium acnes bacteria. Because nanogels are more stable, translucent, and have small particle sizes making them efficient in releasing active chemicals and increasing bioavailability, nanogels are used in tropical medicine. Maceration is the extraction technique used. Nanogel of butterfly pea flower ethanol extract (BPFEE) was added to the nanogel formulation at concentrations of F1 (5%), F2 (10%), and F3 (15%). Transmission testing is part of the ideal formula; Other tests for characterization include phytochemical, organoleptic, particle size, pH, adhesion, spreadability and viscosity tests. Next, antibacterial activity was tested against Propionibacterium acnes using the well method. The research results showed that the % transmittance was 84-88%, the organoleptic results were in the form of a gel, color and distinctive aroma, particle size 114.9 – 283.9 mm, pH 5.6 – 6, adhesive power 1.36 – 2.1 seconds, spreadability 4.8-5.6 cm, viscosity 4071 – 3043.75 mPa.S. Telang flower ethanol extract nanogel can inhibit the growth of P. acnes bacteria, namely 8.2-11.7 mm.
Effect of Premna serratifolia Leaf Ethanol Extract on Pancreatic Histopathology in Hypercholesterolemic Diabetic Rats Wayan Wirawan; Niluh Puspita Dewi; Yasinta Rakanita; Matra Novalia Palipadang; Magfirah; Nuraisya; Ni Ketut Marlina
Jurnal Jamu Indonesia Vol. 11 No. 5 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i5.466

Abstract

This study evaluated the protective effect of Premna serratifolia leaf ethanol extract on pancreatic histopathology in hypercholesterolemic diabetic rats. Thirty male rats (n = 5/group) were assigned to normal, negative, and positive (metformin) controls and extract-treated groups (200, 300, and 400 mg/kg BW). Phytochemical screening detected alkaloids, flavonoids, saponins, and tannins in the extract. Pancreatic damage scores differed significantly among groups (Kruskal–Wallis H(5) = 20.13, p = 0.001, ε² = 0.63). After correcting for multiple comparisons, damage scores at 300 and 400 mg/kg were significantly lower than the negative control, while 200 mg/kg was not. No extract dose differed significantly from the positive control or from each other, so a clear dose-response pattern was not established; 300 mg/kg gave the numerically lowest mean damage score. These findings indicate that P. serratifolia leaf ethanol extract has a protective, though only partly dose-related, effect against pancreatic damage in hypercholesterolemic diabetic rats.
Co-Authors Indah Kurnia Utami Magfirah Matra Novalia Palipadang Ni Ketut Marlina Ni Ketut Marlina Niluh Puspita Dewi Niluh Puspita Dewi Nur Ramadhani Radhika Wayan Wirawan Yasinta Rakanita Yasinta Rakanita