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All Journal Journal of World Future Medicine, Health and Nursing
Dinda Nurochmah Mujiyati
Universitas Muhammadiyah Surakarta

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IN VITRO POTENTIAL OF A-AMYLASE ENZYME INHIBITION OF A COMBINATION OF ETHANOL EXTRACT OF YAKON POTATO LEAVES (SMALLANTHUS SONCHIFOLIUS) AND KARAS TULANG ROOTS (CHLORANTHUS ERECTUS) AND ITS PHYTOCHEMICAL SCREENING Haryoto Haryoto; Dinda Nurochmah Mujiyati; Agustono Wibowo
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 3 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i3.4032

Abstract

Inhibiting carbohydrate-digesting enzymes such ?-amylase may help regulate type 2 diabetes mellitus, a long-term metabolic condition marked by continuous high blood sugar levels. The purpose of this research was to examine the phytochemical composition and in vitro ?-amylase inhibitory action of a mixture of yacon leaf (Smallanthus sonchifolius) and karas tulang root (Chloranthus erectus) ethanolic extracts. The plant materials were macerated in 70% ethanol to remove their constituent parts, and then the two extracts were mixed in a weight-for-weight ratio of 1:1. The DNS technique was used to assess the ?-amylase inhibitory activity, with acarbose as the positive control, and thin-layer chromatography was used for phytochemical screening. The yield of yacon leaves was 14.2% and that of karas tulang roots was 11.4% when extracted. There were terpenoids, polyphenols, alkaloids, flavonoids, and polyphenols found in the phytochemical screening. The combined extract exhibited an increase in ?-amylase inhibition ratio of 34.528 percent at 20 ppm to 90.359 percent at 200 ppm, which was concentration dependant. The combined extract had an IC?? value of 63.298 ± 0.162 ppm, while acarbose had an IC?? value of 43.183 ± 1.335 ppm. The inhibitory action of the combined extract was encouraging, even if it was not as strong as acarbose. These results indicate that a possible natural antidiabetic candidate might be created by combining yacon leaves and karas tulang roots via ?-amylase inhibition..
Co-Authors Agustono Wibowo Haryoto Haryoto