Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Borneo Journal of Pharmacy Journal of World Future Medicine, Health and Nursing
Agustono Wibowo
Universiti Teknologi MARA Pahang
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Rapid and Controlled: Microflow Reactor-Assisted Synthesis of Cinnamaldehyde and Ethyl Cinnamate along with Their Cytotoxic Activity Against Several Cell Lines Nindita Fransiska Rahmawati; Muhtadi Muhtadi; Andi Suhendi; Ahmad Fauzi; Didin Mujahidin; Ahwan Ahwan; Agustono Wibowo
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.11781

Abstract

Cinnamaldehyde is a major aromatic compound utilized in the pharmaceutical industry due to its diverse biological activities, including anticancer potential. This study aims to develop a rapid and controlled synthesis method for cinnamaldehyde and ethyl cinnamate using microflow reactor technology, followed by structural elucidation and cytotoxic evaluation against HeLa, MCF-7, and T47D cancer cell lines. The synthesis of cinnamaldehyde was performed via aldol condensation of benzaldehyde and acetaldehyde (1.3:1 molar ratio) at 70°C, while ethyl cinnamate was synthesized through a two-step process involving Pinnick oxidation and Fischer esterification. The results demonstrated that microflow synthesis achieved a cinnamaldehyde yield of 52% with high purity (100% based on HPLC relative area), and ethyl cinnamate with 99% purity. In cytotoxic assays, synthesized cinnamaldehyde exhibited moderate activity, most notably against HeLa cells with an IC₅₀ of 95 µg/mL, whereas ethyl cinnamate showed lower potency (IC₅₀ > 200 µg/mL). Although the synthesized compounds were less potent than the standard cinnamaldehyde (IC₅₀ 1.56 µg/mL) and Doxorubicin control, this study confirms that microflow reactor technology is a highly effective and time-efficient method for producing high-purity cinnamate derivatives.
IN VITRO POTENTIAL OF A-AMYLASE ENZYME INHIBITION OF A COMBINATION OF ETHANOL EXTRACT OF YAKON POTATO LEAVES (SMALLANTHUS SONCHIFOLIUS) AND KARAS TULANG ROOTS (CHLORANTHUS ERECTUS) AND ITS PHYTOCHEMICAL SCREENING Haryoto Haryoto; Dinda Nurochmah Mujiyati; Agustono Wibowo
Journal of World Future Medicine, Health and Nursing Vol. 4 No. 3 (2026)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v4i3.4032

Abstract

Inhibiting carbohydrate-digesting enzymes such ?-amylase may help regulate type 2 diabetes mellitus, a long-term metabolic condition marked by continuous high blood sugar levels. The purpose of this research was to examine the phytochemical composition and in vitro ?-amylase inhibitory action of a mixture of yacon leaf (Smallanthus sonchifolius) and karas tulang root (Chloranthus erectus) ethanolic extracts. The plant materials were macerated in 70% ethanol to remove their constituent parts, and then the two extracts were mixed in a weight-for-weight ratio of 1:1. The DNS technique was used to assess the ?-amylase inhibitory activity, with acarbose as the positive control, and thin-layer chromatography was used for phytochemical screening. The yield of yacon leaves was 14.2% and that of karas tulang roots was 11.4% when extracted. There were terpenoids, polyphenols, alkaloids, flavonoids, and polyphenols found in the phytochemical screening. The combined extract exhibited an increase in ?-amylase inhibition ratio of 34.528 percent at 20 ppm to 90.359 percent at 200 ppm, which was concentration dependant. The combined extract had an IC?? value of 63.298 ± 0.162 ppm, while acarbose had an IC?? value of 43.183 ± 1.335 ppm. The inhibitory action of the combined extract was encouraging, even if it was not as strong as acarbose. These results indicate that a possible natural antidiabetic candidate might be created by combining yacon leaves and karas tulang roots via ?-amylase inhibition..
Co-Authors Ahmad Fauzi Ahwan Ahwan Andi Suhendi Didin Mujahidin Dinda Nurochmah Mujiyati Haryoto Haryoto Muhtadi Muhtadi Nindita Fransiska Rahmawati