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p-Index From 2021 - 2026
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All Journal Jurnal Biologi Tropis
Alia Alia
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Association Between BRCA1 Expression Status and Breast Cancer Metastasis Index (cM) in West Nusa Tenggara Alia Alia; Rizka Vidya Lestari; Yan Adhitya Kusuma
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.11751

Abstract

Breast cancer remains a major cause of mortality among Indonesian women, with metastasis as its primary prognostic determinant. Although BRCA1 is a key tumor suppressor involved in genomic stability, its association with the breast cancer metastasis index in Indonesian patients remains limited. This research was designed to evaluate the association between BRCA1 expression and breast cancer metastasis index (cM), as well as differences in BRCA1 expression across metastasis categories. A cross-sectional observational study design was employed using 32 samples selected by purposive sampling, consisting of medical records and paraffin-embedded tissue blocks obtained from Pathology Anatomy Laboratory of the NTB provincial hospital. BRCA1 expression was assessed by immunohistochemistry. Bivariate analysis between variables was performed using the Fisher’s Exact test. Of 32 patients, 78.1% were classified as cM1. No significant association was identified between BRCA1 expression and metastasis index (p = 0.394), although low BRCA1 expression was descriptively more frequent in metastatic cases. BRCA1 expression alone is not an independent determinant of metastasis in breast cancer patients in NTB. This suggests that metastasis is multifactorial. Studies with larger samples and additional biomarkers such as hormonal receptors, proliferation index, and metastasis-related proteins are suggested to investigate the metastatic risk in this population.
Sleep Disorders in Adolescents and Their Impact on Mental Health: A Literature Review Fiyna ’Alyatun Afifah; Rafi Radityo Daniswara; Alia Alia; Aisya Ayudia Azharani
Jurnal Biologi Tropis Vol. 26 No. 4 (2026): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i4.13227

Abstract

Adolescent development is a critical period marked by intensive neurobiological maturation, particularly in the prefrontal cortex and limbic system. Concurrently, sleep architecture undergoes physiological changes, making sleep quality inherently fragile and increasing vulnerability to chronic sleep deprivation. This narrative literature review aims to comprehensively examine adolescent brain maturation, sleep characteristics, the bidirectional relationship between sleep disruption and psychiatric disorders, as well as therapeutic interventions. Based on a review of literature published between 2016 and 2026 retrieved from databases such as PubMed, ScienceDirect, and Google Scholar, sleep deprivation and irregular sleep patterns (social jetlag) are significantly associated with structural brain alterations. These include reduced grey matter volume in the prefrontal cortex, amygdala, and hippocampus, along with disrupted fronto-limbic functional connectivity. Such neurostructural changes impair emotional regulation, executive function, and impulse control. Clinically, sleep disturbances-particularly insomnia-act as bidirectional risk factors and transdiagnostic markers for anxiety, depression, substance abuse, and heightened suicidality in adolescents. Non-pharmacological interventions, specifically Cognitive BehavioralTherapy for Insomnia (CBT-I), demonstrate high efficacy in restoring sleep continuity while simultaneously mitigating psychiatric symptoms. In conclusion, sleep is a clinically relevant marker of adolescent well-being and a modifiable target for early interventionand prevention of adolescent mental health disorders.
Co-Authors Aisya Ayudia Azharani Fiyna ’Alyatun Afifah Rafi Radityo Daniswara Rizka Vidya Lestari Yan Adhitya Kusuma