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All Journal Jurnal Biologi Tropis
Firman Khalif Yuwono
Universitas Mataram
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Upper Airway Obstruction as a Life-Threatening Emergency Firman Khalif Yuwono; Arsy Muchlisa Putri; Baiq Whafiq Azizah; Septrajismi Dinda Juwita; Rina Lestari
Jurnal Biologi Tropis Vol. 26 No. 3 (2026): Juli - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i3.12111

Abstract

Upper airway obstruction (UAO) is a life-threatening emergency characterized by partial or complete blockage of airflow through the upper respiratory tract due to mechanical obstruction or anatomical narrowing. It may occur acutely or chronically and result from congenital or acquired conditions, including infection, inflammation, trauma, malignancy, anatomical abnormalities, and foreign body aspiration. This study employed a literature review by analyzing publications retrieved from PubMed, Google Scholar, and ProQuest. Clinically, UAO presents with noisy breathing, including stertor and stridor, accompanied by dyspnea, dysphagia, hypoxemia, and respiratory distress. Children are particularly susceptible because of their relatively smaller airways. Diagnosis is established through history taking, physical examination, flexible laryngoscopy, and imaging studies such as neck radiography and computed tomography. Management focuses on restoring airway patency and maintaining adequate oxygenation through interventions including endotracheal intubation, tracheostomy, cricothyrotomy, high-flow nasal cannula, continuous positive airway pressure, and the Heimlich maneuver for foreign body airway obstruction. Delayed recognition and treatment may lead to respiratory failure, cardiac arrest, and increased morbidity and mortality. Therefore, early diagnosis and timely emergency management are essential to improve clinical outcomes.
Giant Cell Tumour of Bone: A Comprehensive Review of Clinical Presentation, Diagnosis, and Management Huriyah Nabilah Zhahirah; Azka Fadila Latifa; Muhammad Fatih Ma'ruf; Novad Sawelly; Annisa Fitria Zahra AS; Fidelya Fitria Hakim; I Wayan Putra Kesumantara Wiguna; Sheilla Ninditya Putri; Baiq Tasyfa Hasya Auliya Tsaniya; Firman Khalif Yuwono; Maratun Shulha; Siti Fadilah
Jurnal Biologi Tropis Vol. 26 No. 4 (2026): in Progress
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i4.13267

Abstract

Giant cell tumor of bone (GCTB) is a primary bone tumor generally classified as benign but characterized by locally aggressive behavior, progressive bone destruction, functional impairment, pathological fractures, and a risk of recurrence. This review aimed to provide a comprehensive overview of GCTB by integrating its epidemiological characteristics, molecular mechanisms, clinical manifestations, diagnostic approaches, and management strategies. This study employed a literature review design using relevant scientific literature from journal articles, reviews, books, and other scientific sources. The findings indicate that the biological behavior of GCTB is closely associated with neoplastic stromal cells, molecular alterations involving H3F3A, and the receptor activator of nuclear factor kappa-B ligand (RANKL) pathway, which promotes osteoclast-like giant cell formation and osteolytic bone destruction. Diagnosis requires the integration of clinical findings, radiological evaluation, histopathological examination, and molecular approaches in selected cases. Management strategies should be tailored to lesion characteristics and may include intralesional curettage, en bloc resection, and denosumab therapy, particularly for unresectable, recurrent, metastatic, or surgically challenging cases. This review highlights the interconnected relationship between the molecular basis, clinical presentation, diagnosis, and management of GCTB, providing an integrated perspective that may support appropriate tumor control while preserving patient function and potentially reducing the burden associated with recurrence and repeated interventions.
Co-Authors Annisa Fitria Zahra AS Arsy Muchlisa Putri Azka Fadila Latifa Baiq Tasyfa Hasya Auliya Tsaniya Baiq Whafiq Azizah Fidelya Fitria Hakim Huriyah Nabilah Zhahirah I Wayan Putra Kesumantara Wiguna Maratun Shulha Muhammad Fatih Ma'ruf Novad Sawelly Rina Lestari Septrajismi Dinda Juwita Sheilla Ninditya Putri Siti Fadilah