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All Journal Jurnal Penelitian dan Pengkajian Ilmiah
Bayu Pamungkas
STIKes Bina Cipta Husada Purwokerto
Humanities Computer Science & IT Economics, Econometrics & Finance Environmental Science Public Health

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Evaluasi Pola Peresepan Dan Drug Related Problems Pada Pasien Tuberculosis Paru Di Poliklinik Paru Rumah Sakit Umum X Di Purbalingga Diki Ramadhan; Bayu Pamungkas; Anwar Rosyadi
CENDEKIA : Jurnal Penelitian dan Pengkajian Ilmiah Vol. 3 No. 8 (2026): CENDEKIA : Jurnal Penelitian Dan Pengkajian Ilmiah, Agustus 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/cendekia.v3i8.2893

Abstract

Treatment of pulmonary tuberculosis (TB) with combination  therapy is prone to causing Drug-Related Problems (DRPs). This study aims to evaluate prescribing patterns and their association with the incidence of DRPs among outpatient pulmonary TB patients at X General Hospital in Purbalingga. This retrospective analytical obsevational study used total sampling to analyze 122 prescriptions from Juni to August 2025 using Fisher’s Exact Test . The results showed an average of 6,2 drug items perprescription, with 97,5% of patients experiencing DRP. The most common finding was moderate-level drug interactions (81,6%), the highest incidence of drug interactions was dominated by antituberculosis drugs combined with supportive therapies, such as bronchodilators and antiinflammatory drugs, which can reduce the effectiveness of steroids and increase the risk of heart disease. Bivariate analysis confirmed a significant association between polypharmacy (>3 medication items) and the occurrence of DRPs (p-value = 0,010; RR = 4,958). It was concluded that polypharmacy significantly increases the risk for patients with pulmonary tuberculosis by nearly fivefold, particularly duet o drug interactions.
Co-Authors Anwar Rosyadi Diki Ramadhan