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Rafiatiana Capritasari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health

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Eksplorasi Efek Gastroprotektif Ekstrak Moringa oleifera L. pada Tikus Galur Wistar: Studi in Silico dan in Vivo Febriana Astuti; Dian Anggraini; Feronika Nur Afifa; Rafiatiana Capritasari; Laili Muna
Jurnal Tumbuhan Obat Indonesia Vol. 19 No. 1 (2026): July 2026
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v19i1.3746

Abstract

Gastric ulcers are characterized by gastric mucosal damage caused by an imbalance between aggressive andprotective factors. Synthetic drugs often cause side effects, necessitating natural alternatives such as Moringaoleifera L., which contains the active compound quercetin. Objective to explore the gastroprotective effectsof Moringa oleifera L. leaf extract using in silico and in vivo approaches. Methods used In silico studies wereconducted by molecular docking quercetin against COX-2 protein (PDB ID: 5IKT) and histamine receptor (PDBID: 2AOU). In vivo tests used 25 Wistar rats induced by piroxicam (30 mg/kgBW), divided into negative controlgroups (CMC-Na), positive control groups (Omeprazole), and extract groups with doses of 100 mg/kgBW and200 mg/kgBW. In silico analysis revealed that quercetin has a binding affinity (ΔG) of -6.14 kcal/molfor COX-2 and -7.84 kcal/mol for histamine, indicating stable molecular interactions. In vivo, the 200 mg/kgBWdose provided the most effective protection, with an ulcer inhibition percentage of 30% and visualimprovement of the gastric mucosa compared to the negative control. Moringa oleifera L. leafextract possesses potential as a gastroprotective agent through the inhibition of inflammatory mediators andgastric acid secretion Keywords: Moringa oleifera, quercetin, gastroprotective, molecular docking, gastric ulcer
Co-Authors Dian Anggraini Febriana Astuti Feronika Nur Afifa Laili Muna