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All Journal Journal of Tropical Chemistry Research and Education Sasambo Journal of Pharmacy Jurnal Tumbuhan Obat Indonesia
Laili Muna
UIN Sunan kalijaga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Medicine & Pharmacology Public Health

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Analisis Pembelajaran Kontekstual berbasis Bahan Alam Pada Penentuan Kadar Vitamin C Daun Katuk (Sauropus Androgynus) sebagai Alternatif Sumber Belajar Kimia Laili Muna
Journal of Tropical Chemistry Research and Education Vol 4 No 2 (2022)
Publisher : Chemistry Education Department, Faculty of Tarbiyah and Education, UIN Sunan Kalijaga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/jtcre.2022.42-01

Abstract

Pembelajaran kontekstual berbasis bahan alam yang menghubungkan situasi kehidupan nyata kedalam kegiatan pembelajaran perlu diterapkan guna meningkatkan kemampuan berpikir kritis peserta didik. Penelitian ini bertujuan untuk mengetahui kadar vitamin C daun katuk (Sauropus androgynus) setelah mengalami variasi waktu perebusan serta menganalisis kesesuaian materi kimia SMA/MA dalam proses penentuan kadar vitamin C. Penelitian dilakukan menggunakan pendekatan campuran kuantitatif dan kualitatif (mixed-methods research). Kadar vitamin C daun katuk (Sauropus androgynus) ditentukan menggunakan analisis kuantitatif metode titrasi redoks iodimetri melalui percobaan sederhana laboratorium dan analisis ANOVA single factor untuk mengetahui pengaruh pemanasan terhadap kadar vitamin C sampel. Analisis kurikulum 2013 materi kimia SMA/MA, distribusi materi serta pemaparan keterkaitan materi dalam proses penentuan kadar vitamin C dilakukan melalui studi literatur dan telaah kurikulum dengan analisis deskriptif kualitatif. Berdasarkan hasil percobaan dan perhitungan menunjukkan bahwa hasil kadar vitamin C pada sampel maserasi sebesar 14,0346 % b/v dan setelah perlakuan variasi waktu perebusan secara signifikan mengalami penurunan kadar dari 11,7466 % b/v (pemanasan 3 menit) menjadi 9,7606 % b/v (pemanasan 5 menit) dan semakin turun menjadi 6,5574 % b/v (pemanasan 10 menit). Adapun berdasarkan analisis kajian kurikulum terhadap keterkaitan proses penentuan kadar vitamin C menunjukkan bahwa proses penentuan kadar vitamin C daun katuk menggunakan metode titrasi redoks iodimetri sangat berpotensi untuk diterapkan sebagai sumber belajar kimia kontekstual berbasis bahan alam. Konsep-konsep dalam proses penentuan kadar vitamin C sesuai dan relevan dengan materi pembelajaran kimia SMA/MA Kurikulum 2013 di sekolah.
Aktivitas antioksidan ekstrak air daun kelor (Moringa oleifera) dengan metode DPPH serta analisis kualitatif kandungan metabolit sekunder Laili Muna
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.182

Abstract

Sunlight contains UV radiation which will have an impact on the skin if exposed continuously and cause premature aging of the skin. The use of cosmetic products that contain antioxidant compounds is needed to avoid premature aging due to exposure to UV rays. Antioxidants used in cosmetics generally come from synthetic compounds, namely BHT (Butyl hydroxytoluene) whose use will have a negative impact on the skin if used in the long term, so in this study, Moringa oleifera leaf was used as a natural antioxidant. The purpose of this study is to determine the antioxidant activity of Moringa leaf water extract by calculating IC50 and using a comparison standard of vitamin C. The method used in this study is the stratified maceration method with measurement of antioxidant activity using the DPPH method. The results showed that the aqueous extract of Moringa leaves contains secondary metabolites of flavonoids, tannins, saponins, and alkaloids that play a role in antioxidant activity. The test results of Moringa leaf water extract showed moderate antioxidant activity with an IC50 value of 87.54 ppm, while the comparison control vitamin C obtained an IC50 of 483.53 ppm. This is because vitamin C has been oxidized so that the ability to donate protons to DPPH free radicals is also reduced.
Eksplorasi Efek Gastroprotektif Ekstrak Moringa oleifera L. pada Tikus Galur Wistar: Studi in Silico dan in Vivo Febriana Astuti; Dian Anggraini; Feronika Nur Afifa; Rafiatiana Capritasari; Laili Muna
Jurnal Tumbuhan Obat Indonesia Vol. 19 No. 1 (2026): July 2026
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v19i1.3746

Abstract

Gastric ulcers are characterized by gastric mucosal damage caused by an imbalance between aggressive andprotective factors. Synthetic drugs often cause side effects, necessitating natural alternatives such as Moringaoleifera L., which contains the active compound quercetin. Objective to explore the gastroprotective effectsof Moringa oleifera L. leaf extract using in silico and in vivo approaches. Methods used In silico studies wereconducted by molecular docking quercetin against COX-2 protein (PDB ID: 5IKT) and histamine receptor (PDBID: 2AOU). In vivo tests used 25 Wistar rats induced by piroxicam (30 mg/kgBW), divided into negative controlgroups (CMC-Na), positive control groups (Omeprazole), and extract groups with doses of 100 mg/kgBW and200 mg/kgBW. In silico analysis revealed that quercetin has a binding affinity (ΔG) of -6.14 kcal/molfor COX-2 and -7.84 kcal/mol for histamine, indicating stable molecular interactions. In vivo, the 200 mg/kgBWdose provided the most effective protection, with an ulcer inhibition percentage of 30% and visualimprovement of the gastric mucosa compared to the negative control. Moringa oleifera L. leafextract possesses potential as a gastroprotective agent through the inhibition of inflammatory mediators andgastric acid secretion Keywords: Moringa oleifera, quercetin, gastroprotective, molecular docking, gastric ulcer
Co-Authors Dian Anggraini Febriana Astuti Feronika Nur Afifa Rafiatiana Capritasari