Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal International Journal of Public Health Science (IJPHS)
Ikhwan Dahlan Rais
Universitas Ahmad Dahlan
Health Professions

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Nutritional profile and immunomodulatory potential of a polyherbal honey formulation for stunted children Akrom Akrom; Titiek Hidayati; Arif Budi Setianto; Laela Hayu Nurani; Ikhwan Dahlan Rais; Nurkhasanah Nurkhasanah; Lukman Hardia; Prasasti Bintarum; Muslih Anwar
International Journal of Public Health Science (IJPHS) Vol 15, No 3: September 2026
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v15i3.23026

Abstract

Stunting remains a major public health challenge in Indonesia and has been linked to immune dysregulation, including increased pro-inflammatory TNF-α and reduced anti-inflammatory IL-4 activity. Nutrient-dense polyherbal supplementation may provide a complementary strategy to support nutritional status and immune function. This experimental study investigated the nutritional composition and immunomodulatory activity of polyherbal honey (PHH) formulated with curcuma xanthorrhiza, black cumin seeds, and honey. Vitamins, minerals, and bioactive constituents were characterized using laboratory assays. The immunomodulatory effects of PHH were subsequently evaluated in HTB-183 cells by measuring IL-4 and TNF-α expression after exposure to different formulation concentrations. The analysis confirmed the presence of vitamins A, C, and E; calcium and potassium; and several bioactive compounds in the PHH formulation. PHH exposure increased IL-4 expression and reduced TNF-α expression relative to untreated cells, although the magnitude of these responses varied across concentrations. These findings demonstrate that PHH contains nutritional and phytochemical constituents with potential immunomodulatory activity. Further preclinical and clinical investigations are required to determine its efficacy and safety as complementary nutritional support for children with stunting.
Co-Authors Akrom, Akrom Arif Budi Setianto Laela Hayu Nurani Lukman Hardia Muslih Anwar Nurkhasanah Nurkhasanah Prasasti Bintarum Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati