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All Journal International Journal of Health, Engineering and Technology
Aditya Sofyansyah Hermaya
Universitas Muhammadiyah Sumatera Utara
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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In Vitro Activity Of Apigenin And Luteolin Of Durian Peel (Durio Zibethinus Murray) Induced Apoptosis In Cervical Cancer And Molecular Docking Approach: Involvement Of Bcl-2 Pathways Ainur Rofiq; M. Dian Islami; Muhammad Zihni Baihaqi; Aditya Sofyansyah Hermaya; Tristan Kanginan; Humaira Medina Liza Lubis
International Journal of Health Engineering and Technology Vol. 5 No. 3 (2026): Vol. 5 No. 3 SEPTEMBER 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i3.1128

Abstract

Cervical cancer is the fourth most common cancer among women, with resistance to therapy often linked to Bcl-2 overexpression. This study evaluated the anticancer activity of durian peel extract (Durio zibethinus Murray) against HeLa cells through Bcl-2-mediated apoptosis and investigated apigenin and luteolin interactions with Bcl-2 via molecular docking. The extract was prepared by ethanol maceration, characterized by phytochemical screening and GC-MS, and tested for cytotoxicity using the MTT assay, while apoptosis was assessed through Bcl-2 immunofluorescence. Phytochemical screening confirmed flavonoids, alkaloids, saponins, tannins, and triterpenoids, with GC-MS identifying over 93 bioactive compounds. The extract exhibited significant cytotoxicity with an IC₅₀ of 5.92 μg/mL, and cell viability decreased concentration-dependently (p < 0.05), accompanied by apoptotic morphological changes and reduced Bcl-2 expression. Molecular docking revealed favorable binding of apigenin and luteolin to Bcl-2, with binding energies of −6.01 and −5.55 kcal/mol, respectively. In conclusion, durian peel extract demonstrates promising anticancer activity against HeLa cells by inducing apoptosis through Bcl-2 suppression, with apigenin and luteolin serving as potential natural candidates for cervical cancer therapy.
Co-Authors Ainur Rofiq Humaira Medina Liza Lubis M. Dian Islami Muhammad Zihni Baihaqi Tristan Kanginan