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All Journal International Journal of Health, Engineering and Technology PROSIDING SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT (SNPPM) UNIVERSITAS MUHAMMADIYAH METRO
M. Dian Islami
Universitas Muhammadiyah Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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MENGUNGKAP KESEHATAN MELALUI ANGKA: PREDIKSI MALNUTRISI MELALUI PENILAIAN STATUS GIZI DAN ASUPAN MAKRONUTRIEN Bunail Isna Alfarisi; Annisa Rifqa Hestiana; Aisyah Salsabila; Nesya Alya Fayyaza; M. Dian Islami; Galang Ramadhan; Afif Fadhilah Irsyad; Laden; Humairah Medina Liza Lubis
SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Vol 5 No 1 (2023): SNPPM 5 Universitas Muhammadiyah Metro
Publisher : Universitas Muhammadiyah Metro

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Abstract

Status gizi dapat dinilai dari kebutuhan dan asupan nutrisi yang berbeda pada tiap individu. Ketidakseimbanganantara kebutuhan dan asupan nutrisi dapat mengakibatkan kekurangan atau kelebihan energi, protein,makronutrien dan mikronutrien yang dapat berdampak negatif terhadap pertumbuhan dan perkembangan anak.Tujuan penelitian ini adalah, 1) Mendapatkan kasus malnutrisi; 2) Mendapatkan jumlah balita yang melakukancek rutin kesehatan di posyandu setempat; 3) Melakukan edukasi tentang makanan sehat dan bergizi seimbang; 4)Memberikan makanan tambahan kepada anak balita; 5) Membantu program pemerintah dalam menemukankasus malnutrisi sedini mungkin untuk menurunkan angka kesakitan dan kematian. Metode dan langkahkegiatan yang digunakan adalah: 1) Kunjungan posyandu; 2) Pendataan dan pemantauan kesehatan terhadapanak balita; 3) Sosialisasi dan edukasi kepada masyarakat; 4) Pemberian makanan tambahan kepada anak balita.Hasil yang diperoleh adalah 1) Didapatkan kasus malnutrisi dengan gizi kurang berdasarkan berat badan per usiasebanyak 4 orang (16%); 2) Didapatkan jumlah balita yang ditimbang dan melakukan cek rutin kesehatan diposyandu setempat sebanyak 25 orang; 3) Edukasi tentang makanan sehat dan bergizi seimbang; 4) Memberikanmakanan tambahan kepada anak balita untuk pencegahan malnutrisi berupa susu, crackers, pisang dan buburkacang hijau; 6) Melaporkan kasus gizi kurang pada instansi terkait yaitu Puskesmas Sambirejo dan DinasKesehatan Kabupaten Langkat untuk ditindaklanjuti.
In Vitro Activity Of Apigenin And Luteolin Of Durian Peel (Durio Zibethinus Murray) Induced Apoptosis In Cervical Cancer And Molecular Docking Approach: Involvement Of Bcl-2 Pathways Ainur Rofiq; M. Dian Islami; Muhammad Zihni Baihaqi; Aditya Sofyansyah Hermaya; Tristan Kanginan; Humaira Medina Liza Lubis
International Journal of Health Engineering and Technology Vol. 5 No. 3 (2026): Vol. 5 No. 3 SEPTEMBER 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i3.1128

Abstract

Cervical cancer is the fourth most common cancer among women, with resistance to therapy often linked to Bcl-2 overexpression. This study evaluated the anticancer activity of durian peel extract (Durio zibethinus Murray) against HeLa cells through Bcl-2-mediated apoptosis and investigated apigenin and luteolin interactions with Bcl-2 via molecular docking. The extract was prepared by ethanol maceration, characterized by phytochemical screening and GC-MS, and tested for cytotoxicity using the MTT assay, while apoptosis was assessed through Bcl-2 immunofluorescence. Phytochemical screening confirmed flavonoids, alkaloids, saponins, tannins, and triterpenoids, with GC-MS identifying over 93 bioactive compounds. The extract exhibited significant cytotoxicity with an IC₅₀ of 5.92 μg/mL, and cell viability decreased concentration-dependently (p < 0.05), accompanied by apoptotic morphological changes and reduced Bcl-2 expression. Molecular docking revealed favorable binding of apigenin and luteolin to Bcl-2, with binding energies of −6.01 and −5.55 kcal/mol, respectively. In conclusion, durian peel extract demonstrates promising anticancer activity against HeLa cells by inducing apoptosis through Bcl-2 suppression, with apigenin and luteolin serving as potential natural candidates for cervical cancer therapy.
Co-Authors Aditya Sofyansyah Hermaya Afif Fadhilah Irsyad Ainur Rofiq Aisyah Salsabila Annisa Rifqa Hestiana Bunail Isna Alfarisi Galang Ramadhan Humaira Medina Liza Lubis Humairah Medina Liza Lubis Laden Muhammad Zihni Baihaqi Nesya Alya Fayyaza Tristan Kanginan