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All Journal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS
Bunga Tamama Hapidzhah
STIKES AL-FATAH BENGKULU
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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FORMULASI DAN EVALUASI SEDIAAN NANOGEL CIPROFLOXACIN Bunga Tamama Hapidzhah; Tri Yanuarto; Dewi Winni Fauziah
Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS Vol. 8 No. 1 (2026): Agustus
Publisher : Program Studi Farmasi, Universitas Muhadi Setiabudi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46772/jophus.v8i1.1942

Abstract

Biopharmaceutical systems have deficiencies in solubility properties in gastrointestinal lumen fluids. Deficiencies in the main biopharmaceutical can reduce the rate and amount of absorbed doses in oral dosage forms. Ciprofloxacin is one of the drugs included in biopharmaceutical class 3. This study formulated ciprofloxacin into nanogel preparations with different concentrations of 0.3%, 0.4%, and 0.5%. The study conducted evaluation tests including particle size tests, polydispersity index, and physical properties tests (organoleptic, viscosity, homogeneity, pH tests). The results of this tests showed that the particle size test has a size ofapproximately 403,9 nm – 529,2 nm (qualified) poliydispersity index had a value at F1, F2 of 0,5 (qualified) at F3 0,7 (not qualified) and the physical properties test (organoleptic, viscosity, homogeneity) qualified, the pH test showed the results of the pH value in the range of 4.55 - 5.5 (qualified).
Co-Authors Dewi Winni Fauziah Tri Yanuarto