<![CDATA[ABSTRACT Variations in learning experiences are worth considering when biology content requires students to understand information through visual and dynamic representations. This study examines the use of Animasi E-Pop Up Book in teaching the reproductive system and its relationship to the learning interest of Grade XI students at SMAN 7 Bone. A total of 64 students participated, comprising 31 students from class XI F1 and 33 students from class XI F2, assigned to the experimental and control groups through purposive sampling. The study employed a quantitative approach using a quasi-experimental method with a nonequivalent control group pretest–posttest design. Learning interest was measured using a questionnaire developed by the researchers covering interest, attention, engagement and active participation, and enjoyment; the instrument was deemed appropriate following validation by two expert lecturers. The mean score increased from 74.16 to 79.71 in the experimental group, whereas the control group showed only a slight change from 73.06 to 73.12. The data were normally distributed, but the variances between groups were not homogeneous; therefore, differences were examined using Welch's Independent Samples t-Test. The significance value of 0.001 (p < 0.05) indicates a difference in students' learning interest between the two groups. These findings position Animasi E-Pop Up Book as a relevant digital media alternative for supporting learning experiences and students' interest in reproductive system topics. ABSTRAK Variasi pengalaman belajar menjadi salah satu aspek yang perlu diperhatikan ketika materi biologi menuntut siswa memahami informasi melalui representasi visual dan dinamis. Penelitian ini menelaah penggunaan media Animasi E-Pop Up Book dalam pembelajaran sistem reproduksi dan kaitannya dengan minat belajar siswa kelas XI SMAN 7 Bone. Sebanyak 64 siswa terlibat, terdiri atas 31 siswa kelas XI F1 dan 33 siswa kelas XI F2 yang ditempatkan sebagai kelompok eksperimen dan kontrol melalui purposive sampling. Penelitian berlangsung dengan pendekatan kuantitatif melalui quasi experiment dan desain nonequivalent control group pretest–posttest. Minat belajar diukur menggunakan kuesioner yang dikembangkan peneliti dan mencakup ketertarikan, perhatian, keterlibatan dan keaktifan, serta perasaan senang; instrumen telah dinyatakan layak melalui validasi dua dosen ahli. Perubahan skor memperlihatkan kenaikan rata-rata kelompok eksperimen dari 74,16 menjadi 79,71, sedangkan kelompok kontrol hanya bergerak dari 73,06 menjadi 73,12. Data berdistribusi normal, tetapi varians antarkelompok tidak homogen, sehingga perbedaan diuji menggunakan Welch's Independent Samples t-Test. Nilai signifikansi sebesar 0,001 (p < 0,05) menunjukkan adanya perbedaan minat belajar antara kedua kelompok. Temuan ini menempatkan Animasi E-Pop Up Book sebagai alternatif media digital yang relevan untuk mendukung pengalaman belajar dan minat siswa pada materi sistem reproduksi.]]>
