This study was motivated by the limited variety of Biology teaching materials in schools—which remain dominated by printed textbooks and student worksheets—resulting in low student learning motivation and difficulties in grasping concepts related to the human digestive system. The study aimed to: (1) assess the feasibility of a Construct 2-based educational game on the digestive system for Grade XI high school students, and (2) determine student responses to the use of this game-based learning medium. This study employed the Research and Development (R&D) method using the ADDIE model (Analyze, Design, Development, Implementation, Evaluation), though it was limited to the Development stage due to time and budget constraints. Data were collected through interviews, a needs analysis questionnaire, expert validation sheets, and student response questionnaires. The data were Analyzed using both descriptive qualitative and quantitative methods. The results indicated that the Construct 2-based game achieved high validity ratings: 94% from subject matter experts, 90% from media experts, and 96% from instructional design experts, resulting in an overall average validity of 93.33% (categorized as highly valid/feasible). The overall student response test yielded an average score of 92% (categorized as "very good"), covering aspects such as product appearance (94%), readability (91%), language (94%), content (95%), and presentation/motivation (92%). Thus, the Construct 2-based interactive multimedia game on the digestive system is deemed highly valid and practical for use as a learning medium for Grade XI high school Biology.