ABSTRACT Hospital Information Management Systems (HIMS) are crucial for supporting inpatient services that demand speed and information reliability. However, implementation challenges still potentially affect nurse satisfaction. This study aims to analyze the influence of End-User Computing Satisfaction (EUCS) dimensions content, accuracy, format, timeliness, and ease of use on nurse satisfaction at Banjarmasin Islamic Hospital. Using a quantitative cross-sectional approach, this study involved 61 nurses as samples through a total sampling technique. Data were analyzed using multiple linear regression, F-tests, and t-tests. Results showed that simultaneously, all EUCS dimensions significantly influenced nurse satisfaction (p 0.05). Partially, the variables of content, accuracy, timeliness, and ease of use had a significant effect, while the format variable showed no significant influence. An Adjusted R Square value of 79.6% confirms the strong impact of these five dimensions. It is concluded that nurse satisfaction is more driven by functional aspects than the system’s interface. Therefore, HIMS development should prioritize information completeness, accuracy, timeliness, and ease of use. Keywords: End-User Computing Satisfaction (EUCS), Hospital Information System (HIS). Nurse satisfaction. ABSTRAK Sistem Informasi Manajemen Rumah Sakit (SIMRS) sangat krusial dalam mendukung pelayanan rawat inap yang menuntut kecepatan dan keandalan informasi. Namun, kendala implementasi di lapangan masih berpotensi memengaruhi kepuasan perawat. Penelitian ini bertujuan menganalisis pengaruh dimensi End User Computing Satisfaction (EUCS) content, accuracy, format, timeliness, dan ease of use—terhadap kepuasan perawat di Rumah Sakit Islam Banjarmasin. Melalui pendekatan kuantitatif cross-sectional, penelitian ini melibatkan 61 perawat sebagai sampel dengan teknik total sampling. Data dianalisis menggunakan regresi linier berganda, uji F, dan uji t. Hasil penelitian menunjukkan bahwa secara simultan, seluruh dimensi EUCS berpengaruh signifikan terhadap kepuasan perawat (p 0,05). Secara parsial, variabel content, accuracy, timeliness, dan ease of use berpengaruh signifikan, sementara variabel format tidak menunjukkan pengaruh signifikan. Nilai Adjusted R Square sebesar 79,6% menegaskan kuatnya pengaruh kelima dimensi tersebut. Disimpulkan bahwa kepuasan perawat lebih didominasi oleh aspek fungsional sistem daripada tampilan. Oleh karena itu, pengembangan SIMRS harus diprioritaskan pada kelengkapan informasi, akurasi, ketepatan waktu, dan kemudahan penggunaan sistem. Kata Kunci: End User Computing Satisfaction, Kepuasan Perawat, Sistem Informasi Rumah Sakit.