Premenopause is the transitional period that women experience as they approach the end of their reproductive years. This phase begins when menstruation becomes irregular and physical and psychological symptoms arise. These symptoms are referred to as premenopausal syndrome. These symptoms occur two to five years before menopause. Approximately 40% of women were postmenopausal, 40% of whom resided in developing countries where the average age of menopause onset was between 40 and 44 years. Many women lack awareness and knowledge about the physiological changes, nutrition, and physical activity needs during premenopause, leading to increased anxiety as they enter this transitional period. This program aims to evaluate the impact of the CERDIK Program on the knowledge of premenopausal women. CERDIK program includes health checks, reproductive health education, regular physical activity, a balanced diet, adequate rest, and stress management. The program was designed and implemented using the Research and Development method, structured into five sequential stages over six months. The process began with a needs analysis survey of the target community, followed by the collaborative development of the CERDIK educational modules and tools. These materials were then implemented in a series of interactive workshops. The program's effectiveness was quantitatively evaluated through pre- and post-tests measuring knowledge gain and qualitatively assessed via participant feedback sessions to gauge practical utility and satisfaction. These results showed a significant increase in knowledge, with mean scores rising from 47.14 (pretest) to 65.36 (post-test). Beyond improved test scores, the program’s impact on the community included greater health awareness, reduced anxiety about premenopause, and the adoption of healthier lifestyle practices.