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All Journal Asian Journal of Fertility, Endocrinology, and Reproduction
Pande Made Dwijayasa
Department of Obstetric and Ginecology, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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The Anti-Inflammatory Effects of Genistein Inhibits Tumor Necrosis Factor-Α Receptor 1 (TNF-R1) and IL-8 Receptor (CXCR-1) Levels in Peritoneal Endometriosis Lesion of Mice Model Endometriosis Sutrisno Sutrisno; Cholid Rochman Riskianto; Yulianto Rapa; Nina Rini Suprobo; Pande Made Dwijayasa
ASIAN JOURNAL OF FERTILITY ENDOCRINOLOGY AND REPRODUCTION Vol. 1 No. 1 (2026): January 2026
Publisher : Malang Reproductive Training Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66060/ajfer.v1i1.9

Abstract

Introduction: Endometriosis is a complex condition that typically causes an inflammatory reaction in the peritoneal cavity. Tumor Necrosis Factor-α receptor 1 (TNF-R1) and IL-8 receptor (CXCR-1) are thought to play a role in the pathophysiology of endometriosis. This study evaluates the effects of genistein at various doses on the content of TNF-R1 and CXCR1 in the peritoneal endometriosis lesions in mice model of endometriosis. Methods: This experiment study, a total 32 female mice (Mus musculus) with induced endometriosis were allocated to the eight groups (n=4 per group), including a control group, endometriosis model group (EM), and six groups treated with different doses of genistein (0.13, 0.26, 0.52, 0.78, 1.04, and 1.30 mg/day) for 14 days. The peritoneal endometriosis lesion was then measured for TNF-R1 and CXCR-1 levels. Results: The level of TNF-R1 and CXCR-1 in the EM group was significantly elevated compared to the control group. Following genistein administration, TNF-R1 and CXCR-1 levels were significantly lower than in the EM group. Conclusion: Genistein has an anti-inflammatory effect, reducing TNF-R1 and CXCR-1 in mice model of peritoneal endometriosis and could be a potential treatment for endometriosis.
Co-Authors Cholid Rochman Riskianto Nina Rini Suprobo Sutrisno Sutrisno Yulianto Rapa